Reviewed, UniProtKB/Swiss-Prot P24005 (ACTB_DICDI)

Names and origin

Protein names

Recommended name:
    Calcium-regulated actin-bundling protein
Alternative name(s):
    34 kDa actin-binding protein

Gene names

Name:	abpB
ORF Names:	DDB_0214810

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May contribute to the structure and reorganization of filopodia and pseudopodia accompanying cell movements.
Subunit structure	Monomer.

Ontologies

Keywords
Ligand	Actin-binding Calcium
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 295	295	Calcium-regulated actin-bundling protein
Regions
	Compositional bias	256 – 275	20	Ala/Gly/Ser-rich
	Compositional bias	286 – 295	10	Arg/Lys-rich (basic)

Sequences

	Sequence		Length	Mass (Da)
	P24005-1 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: 1BBF85DEA657097D	FASTA	295	33,353
	10 20 30 40 50 60 MAETKVAPNL TGIEQTKAGQ SFTEKLSAEA MEFFCNVAKL PFSQQAVHFL NAYWAEVSKE 70 80 90 100 110 120 AEFIYSVGWE TIKYADMHCK GIQLVFKYDE GNDLDFDIAL YFYEQLCKFC EDPKNKNYAT 130 140 150 160 170 180 TYPISQPQML TALKRKQELR EKVDVNFDGR VSFLEYLLYQ YKDFANPADF CTRSMNHDEH 190 200 210 220 230 240 PEIKKARLAL EEVNKRIRAY EEEKARLTEE SKIPGVKGLG ATNMLAQIDS GPLKEQLNFA 250 260 270 280 290 LISAEAAVRT ASKKYGGAAY SGGAGDAGAG SSAGAIWWMN RDLEEKKKRY GPQKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequencing of cDNA clones encoding the Dictyostelium discoideum 30,000-dalton actin-bundling protein." Fechheimer M., Murdock D., Carney M., Glover C.V.C. J. Biol. Chem. 266:2883-2889(1991) [PubMed: 1993662] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 7-22 AND 225-237.
[2]	"Dictyostelium discoideum cells lacking the 34,000-dalton actin-binding protein can grow, locomote, and develop, but exhibit defects in regulation of cell structure and movement: a case of partial redundancy." Rivero F., Furukawa R., Noegel A.A., Fechheimer M. J. Cell Biol. 135:965-980(1996) [PubMed: 8922380] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX3.
[3]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[4]	"Identification and isolation of Dictyostelium microtubule-associated protein interactors by tandem affinity purification." Koch K.V., Reinders Y., Ho T.-H., Sickmann A., Graef R. Eur. J. Cell Biol. 85:1079-1090(2006) [PubMed: 16782229] [Abstract] Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M58022 mRNA. Translation: AAA33144.1. Z50156 Genomic DNA. Translation: CAA90518.1. U32112 Genomic DNA. Translation: AAB48216.1. AAFI02000027 Genomic DNA. Translation: EAL67879.1.
PIR	A23750.
RefSeq	XP_641862.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3392967.
KEGG	ddi:DDB_0214810.
Organism-specific databases
dictyBase	DDB0214810. abpB.
Family and domain databases
InterPro	IPR002048. EF_hand_Ca_bd. [Graphical view]
ProDom	P24005. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACTB_DICDI

Accession

Primary (citable) accession number: P24005
Secondary accession number(s): Q54XA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	September 23, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)