Reviewed, UniProtKB/Swiss-Prot P26201 (CD36_BOVIN)

Names and origin

Protein names

Recommended name:
    Platelet glycoprotein 4
Alternative name(s):
    Platelet glycoprotein IV
      Short name=GPIV
    GPIIIB
    PAS IV
    PAS-4
    CD_antigen=CD36

Gene names

Name:	CD36
Synonyms:	PAS4

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the CD36 family.

Ontologies

Keywords
Biological process	Cell adhesion Transport
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Receptor
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 472	471	Platelet glycoprotein 4
Regions
	Topological domain	2 – 7	6	Cytoplasmic Potential
	Transmembrane	8 – 29	22	Potential
	Topological domain	30 – 439	410	Extracellular Potential
	Transmembrane	440 – 461	22	Potential
	Topological domain	462 – 472	11	Cytoplasmic Potential
Amino acid modifications
	Lipidation	3	1	S-palmitoyl cysteine By similarity
	Lipidation	7	1	S-palmitoyl cysteine By similarity
	Lipidation	464	1	S-palmitoyl cysteine By similarity
	Lipidation	466	1	S-palmitoyl cysteine By similarity
	Glycosylation	79	1	N-linked (GlcNAc...)
	Glycosylation	102	1	N-linked (GlcNAc...)
	Glycosylation	172	1	N-linked (GlcNAc...)
	Glycosylation	205	1	N-linked (GlcNAc...)
	Glycosylation	235	1	N-linked (GlcNAc...)
	Glycosylation	247	1	N-linked (GlcNAc...)
	Glycosylation	321	1	N-linked (GlcNAc...)
	Glycosylation	417	1	N-linked (GlcNAc...)
	Disulfide bond	243 ↔ 311
	Disulfide bond	272 ↔ 333
	Disulfide bond	313 ↔ 322
Experimental info
	Sequence conflict	39	1	K → N in CAA62803. Ref.2
	Sequence conflict	110	1	H → N in BAA08224. Ref.1
	Sequence conflict	125	1	S → L in BAA08224. Ref.1
	Sequence conflict	134	1	T → K in BAA08224. Ref.1
	Sequence conflict	257	1	F → L in BAA08224. Ref.1
	Sequence conflict	294	1	I → V in BAA08224. Ref.1
	Sequence conflict	305	1	Q → E in BAA08224. Ref.1
	Sequence conflict	359	1	S → G in BAA08224. Ref.1
	Sequence conflict	391 – 396	6	MLVKPA → TGQARQ in BAA08224. Ref.1
	Sequence conflict	466	1	C → Y in BAA08224. Ref.1
	Sequence conflict	470 – 472	3	RVN → TIK in BAA08224. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P26201-1 [UniParc]. Last modified January 23, 2007. Version 5. Checksum: D864D6D3D6E8622F	FASTA	472	52,940
	10 20 30 40 50 60 MGCNRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKK EVVLEEGTIA FKNWVKTGTD 70 80 90 100 110 120 VYRQFWIFDV QNPDEVTVNS SKIKVKQRGP YTYRVRYLAK ENITQDPETH TVSFLQPNGA 130 140 150 160 170 180 IFEPSLSVGT EDDTFTILNL AVAAAPQLYP NTFMQGILNS FIKKSKSSMF QNRTLKELLW 190 200 210 220 230 240 GYTDPFLNLV PYPITTTIGV FYPYNNTADG IYKVFNGKDD ISKVAIIDTY KGRKNLSYWS 250 260 270 280 290 300 SYCDLINGTD AASFPPFVEK TRVLQFFSSD ICRSIYAVFG AEINLKGIPV YRFILPSFAF 310 320 330 340 350 360 ASPFQNPDNH CFCTEKIISK NCTLYGVLDI GKCKEGKPVY ISLPHFLHGS PELAEPIESL 370 380 390 400 410 420 SPNEEEHSTY LDVEPITGFT LRFAKRLQVN MLVKPAKKIE ALKNLKHNYI VPILWLNETG 430 440 450 460 470 TIGDEKAEMF RNQVTGKINL LGLVEIVLLS VGVVMFIAFM ISYCACRSKR VN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of PAS-4 from bovine fat globule membrane." Hwangbo S., Ametani M., Kanno C. Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Holstein. Tissue: Mammary gland.
[2]	"Structural characterization of bovine CD36 from the milk fat globule membrane." Berglund L., Petersen T.E., Ramussen J.T. Biochim. Biophys. Acta 1309:63-68(1996) [PubMed: 8950178] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION AT ASN-79; ASN-102; ASN-172; ASN-205; ASN-235; ASN-247; ASN-321 AND ASN-417. Tissue: Mammary gland.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.
[4]	"Structural, functional, and antigenic differences between bovine heart endothelial CD36 and human platelet CD36." Greenwalt D.E., Watt K.W.K., Hasler T., Howard R.J., Patel S. J. Biol. Chem. 265:16296-16299(1990) [PubMed: 1697855] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-22. Tissue: Heart.
[5]	"PAS IV, an integral membrane protein of mammary epithelial cells, is related to platelet and endothelial cell CD36 (GP IV)." Greenwalt D.E., Watt K.W., So O.Y., Jiwani N. Biochemistry 29:7054-7059(1990) [PubMed: 1699598] [Abstract] Cited for: PROTEIN SEQUENCE OF 4-22 AND 214-223. Tissue: Mammary epithelium.
[6]	"Assignment of disulfide bridges in bovine CD36." Rasmussen J.T., Berglund L., Rasmussen M.S., Petersen T.E. Eur. J. Biochem. 257:488-494(1998) [PubMed: 9826197] [Abstract] Cited for: DISULFIDE BONDS. Tissue: Milk.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D45364 mRNA. Translation: BAA08224.1. X91503 mRNA. Translation: CAA62803.1. BC103112 mRNA. Translation: AAI03113.1.
RefSeq	NP_776435.1.
UniGene	Bt.43948
3D structure databases
ModBase	Search...
PTM databases
GlycoSuiteDB	P26201.
Genome annotation databases
Ensembl	ENSBTAG00000017866. Bos taurus. [Contig view]
GeneID	281052.
KEGG	bta:281052.
Phylogenomic databases
HOVERGEN	P26201.
Family and domain databases
InterPro	IPR002159. CD36. IPR005428. CD36_antigen. [Graphical view]
PANTHER	PTHR11923. CD36. 1 hit.
Pfam	PF01130. CD36. 1 hit. [Graphical view]
PRINTS	PR01610. CD36ANTIGEN. PR01609. CD36FAMILY.
ProDom	P26201. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CD36_BOVIN

Accession

Primary (citable) accession number: P26201
Secondary accession number(s): P79111, Q28154, Q3ZBT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 66 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)