Activin receptor type-2B precursor - Mus musculus (Mouse)

Names and origin

Protein names

Recommended name:
    Activin receptor type-2B
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIB
      Short name=ACTR-IIB

Gene names

Name:

Acvr2b

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

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Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	activation of protein kinase activity Inferred from direct assay. Source: MGI anterior/posterior pattern formation Inferred from mutant phenotype. Source: MGI determination of left/right symmetry Inferred from mutant phenotype. Source: MGI embryonic foregut morphogenesis Inferred from mutant phenotype. Source: MGI gastrulation with mouth forming second Inferred from genetic interaction. Source: MGI heart development Inferred from mutant phenotype. Source: MGI insulin secretion Inferred from genetic interaction. Source: MGI kidney development Inferred from genetic interaction. Source: MGI lung development Inferred from genetic interaction. Source: MGI mesoderm development Inferred from genetic interaction. Source: MGI odontogenesis of dentine-containing tooth Inferred from mutant phenotype. Source: MGI organ growth Inferred from genetic interaction. Source: MGI palate development Inferred from genetic interaction. Source: MGI pancreas development Inferred from genetic interaction. Source: MGI post-embryonic development Inferred from genetic interaction. Source: MGI response to glucose stimulus Inferred from genetic interaction. Source: MGI skeletal morphogenesis Inferred from mutant phenotype. Source: MGI
Molecular function	activin binding Ref.1 Inferred from direct assay. Source: MGI growth factor binding Inferred from mutant phenotype. Source: MGI protein serine/threonine kinase activity Inferred from direct assay. Source: MGI protein serine/threonine/tyrosine kinase activity Inferred from direct assay. Source: MGI
Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Notes: ActR-IIB1 and ActR-IIB2 have similar but higher affinities for activin A than ActR-II, ActR-IIB3 and ActR-IIB4.

Isoform ActR-IIB1 (identifier: P27040-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform ActR-IIB2 (identifier: P27040-2) The sequence of this isoform differs from the canonical sequence as follows: 175-198: Missing.

Isoform ActR-IIB3 (identifier: P27040-3) The sequence of this isoform differs from the canonical sequence as follows: 124-131: Missing.

Isoform ActR-IIB4 (identifier: P27040-4) The sequence of this isoform differs from the canonical sequence as follows: 124-131: Missing. 175-198: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Signal peptide

1 – 18

18

Potential

Chain

19 – 536

518

Activin receptor type-2B

Regions

Topological domain

19 – 137

119

Extracellular Potential

Transmembrane

138 – 158

21

Potential

Topological domain

159 – 536

378

Cytoplasmic Potential

Domain

214 – 504

291

Protein kinase

Nucleotide binding

220 – 228

9

ATP By similarity

Sites

Active site

345

1

Proton acceptor By similarity

Binding site

241

1

ATP By similarity

Amino acid modifications

Glycosylation

42

1

N-linked (GlcNAc...) Potential

Glycosylation

65

1

N-linked (GlcNAc...) Potential

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Natural variations

Alternative sequence

124 – 131

8

Missing in isoform ActR-IIB3 and isoform ActR-IIB4.

Alternative sequence

175 – 198

24

Missing in isoform ActR-IIB2 and isoform ActR-IIB4.

Secondary structure

1

.

536

Helix Strand Turn

Details...

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Sequences

Sequence		Length	Mass (Da)
Isoform ActR-IIB1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: BF1C8CAC974BF5E2 Show »	FASTA	536	60,542
10 20 30 40 50 60 MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 70 80 90 100 110 120 ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEPG 130 140 150 160 170 180 GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEVRQCQR 190 200 210 220 230 240 WAGRRDGCAD SFKPLPFQDP GPPPPSPLVG LKPLQLLEIK ARGRFGCVWK AQLMNDFVAV 250 260 270 280 290 300 KIFPLQDKQS WQSEREIFST PGMKHENLLQ FIAAEKRGSN LEVELWLITA FHDKGSLTDY 310 320 330 340 350 360 LKGNIITWNE LCHVAETMSR GLSYLHEDVP WCRGEGHKPS IAHRDFKSKN VLLKSDLTAV 370 380 390 400 410 420 LADFGLAVRF EPGKPPGDTH GQVGTRRYMA PEVLEGAINF QRDAFLRIDM YAMGLVLWEL 430 440 450 460 470 480 VSRCKAADGP VDEYMLPFEE EIGQHPSLEE LQEVVVHKKM RPTIKDHWLK HPGLAQLCVT 490 500 510 520 530 IEECWDHDAE ARLSAGCVEE RVSLIRRSVN GTTSDCLVSL VTSVTNVDLL PKESSI « Hide
Isoform ActR-IIB2 [UniParc]. Checksum: F8C53AE6D0825D7A Show »		512	57,738
10 20 30 40 50 60 MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 70 80 90 100 110 120 ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEPG 130 140 150 160 170 180 GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP 190 200 210 220 230 240 PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 250 260 270 280 290 300 HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 310 320 330 340 350 360 LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 370 380 390 400 410 420 TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 430 440 450 460 470 480 HPSLEELQEV VVHKKMRPTI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 490 500 510 IRRSVNGTTS DCLVSLVTSV TNVDLLPKES SI « Hide
Isoform ActR-IIB3 [UniParc]. Checksum: 1559B59DEAF7733B Show »		528	59,657
10 20 30 40 50 60 MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 70 80 90 100 110 120 ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEPG 130 140 150 160 170 180 GPEAPTLLTV LAYSLLPIGG LSLIVLLAFW MYRHRKPPYG HVDIHEVRQC QRWAGRRDGC 190 200 210 220 230 240 ADSFKPLPFQ DPGPPPPSPL VGLKPLQLLE IKARGRFGCV WKAQLMNDFV AVKIFPLQDK 250 260 270 280 290 300 QSWQSEREIF STPGMKHENL LQFIAAEKRG SNLEVELWLI TAFHDKGSLT DYLKGNIITW 310 320 330 340 350 360 NELCHVAETM SRGLSYLHED VPWCRGEGHK PSIAHRDFKS KNVLLKSDLT AVLADFGLAV 370 380 390 400 410 420 RFEPGKPPGD THGQVGTRRY MAPEVLEGAI NFQRDAFLRI DMYAMGLVLW ELVSRCKAAD 430 440 450 460 470 480 GPVDEYMLPF EEEIGQHPSL EELQEVVVHK KMRPTIKDHW LKHPGLAQLC VTIEECWDHD 490 500 510 520 AEARLSAGCV EERVSLIRRS VNGTTSDCLV SLVTSVTNVD LLPKESSI « Hide
Isoform ActR-IIB4 [UniParc]. Checksum: 42A315009EE8C17A Show »		504	56,853
10 20 30 40 50 60 MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 70 80 90 100 110 120 ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEPG 130 140 150 160 170 180 GPEAPTLLTV LAYSLLPIGG LSLIVLLAFW MYRHRKPPYG HVDIHEDPGP PPPSPLVGLK 190 200 210 220 230 240 PLQLLEIKAR GRFGCVWKAQ LMNDFVAVKI FPLQDKQSWQ SEREIFSTPG MKHENLLQFI 250 260 270 280 290 300 AAEKRGSNLE VELWLITAFH DKGSLTDYLK GNIITWNELC HVAETMSRGL SYLHEDVPWC 310 320 330 340 350 360 RGEGHKPSIA HRDFKSKNVL LKSDLTAVLA DFGLAVRFEP GKPPGDTHGQ VGTRRYMAPE 370 380 390 400 410 420 VLEGAINFQR DAFLRIDMYA MGLVLWELVS RCKAADGPVD EYMLPFEEEI GQHPSLEELQ 430 440 450 460 470 480 EVVVHKKMRP TIKDHWLKHP GLAQLCVTIE ECWDHDAEAR LSAGCVEERV SLIRRSVNGT 490 500 TSDCLVSLVT SVTNVDLLPK ESSI « Hide

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References

[1]	"Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors." Attisano L., Wrana J.L., Cheifetz S., Massague J. Cell 68:97-108(1992) [PubMed: 1310075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ACTR-IIB1; ACTR-IIB2; ACTR-IIB3 AND ACTR-IIB4). Strain: BALB/c.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

M84120 mRNA. Translation: AAA37172.1.

PIR

A40829.
B40829.
C40829.
D40829.

RefSeq

NP_031423.1.

UniGene

Mm.390239

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1S4Y	X-ray	2.30	A/C	23-120	[»]
2H64	X-ray	1.92	C	19-117	[»]

ModBase

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Protein-protein interaction databases

DIP

DIP:5799N.

Genome annotation databases

Ensembl

ENSMUSG00000061393. Mus musculus. [Contig view]

GeneID

11481.

KEGG

mmu:11481.

Organism-specific databases

MGI

MGI:87912. Acvr2b.

Phylogenomic databases

HOGENOM

P27040.

HOVERGEN

P27040.

Gene expression databases

ArrayExpress

P27040.

CleanEx

MM_ACVR2B.

GermOnline

ENSMUSG00000061393. Mus musculus.

Family and domain databases

InterPro

IPR000333. Activin_II_recpt.
IPR015768. Activin_II_recpt_C.
IPR000472. Activin_rcpt.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
[Graphical view]

PANTHER

PTHR23255:SF10. Activin_II_recpt_C. 1 hit.

Pfam

PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]

PRINTS

PR00653. ACTIVIN2R.

ProDom

PD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

BLOCKS

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Other Resources

SOURCE

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ProtoNet

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Entry information

Entry name

AVR2B_MOUSE

Accession

Primary (citable) accession number: P27040

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	September 23, 2008
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents