Reviewed, UniProtKB/Swiss-Prot P27086 (MTA_COLVI)

Names and origin

Protein names	Recommended name:     Metallothionein A       Short name=MTA
Organism	Colinus virginianus (Bobwhite quail) (Common bobwhite)
Taxonomic identifier	9014 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Odontophoridae › Colinus

Protein attributes

Sequence length	43 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	‹1 – ›43	›43	Metallothionein A
Regions
	Region	‹1 – 16	›16	Beta
	Region	17 – ›43	›27	Alpha
Sites
	Metal binding	2	1	Cluster B
	Metal binding	6	1	Cluster B
	Metal binding	8	1	Cluster B
	Metal binding	11	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	16	1	Cluster B
	Metal binding	20	1	Cluster A
	Metal binding	21	1	Cluster A
	Metal binding	23	1	Cluster A
	Metal binding	24	1	Cluster A
	Metal binding	28	1	Cluster A
	Metal binding	31	1	Cluster A
	Metal binding	35	1	Cluster A
	Metal binding	37	1	Cluster A
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	43	1

Sequences

	Sequence		Length	Mass (Da)
	P27086-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 1612EB52656EB875	FASTA	43	4,401
	10 20 30 40 SCAGSCKCKN CRCRSCRKSC CSCCPAGCNN CAKGCVCKEP ASS

References

[1]

"Evolution of avian metallothionein: DNA sequence analyses of the turkey metallothionein gene and metallothionein cDNAs from pheasant and quail." Shartzer K.L., Kage K., Sobieski R.J., Andrews G.K. J. Mol. Evol. 36:255-262(1993) [PubMed: 8483164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X62511 mRNA. Translation: CAA44370.1.
PIR	S18173. S33378.
3D structure databases
HSSP	HSSP built from PDB template 1JI9 based on UniProtKB P28184.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P27086.
Family and domain databases
InterPro	IPR015874. 4-disulphide_core. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00003. 4DISULPHCORE. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. Partial match. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MTA_COLVI

Accession

Primary (citable) accession number: P27086

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	July 22, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)