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Reviewed, UniProtKB/Swiss-Prot P28286 (5HT2B_DROME)

Last modified July 22, 2008. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    5-hydroxytryptamine receptor 2B
      Short name(s)=5-HT receptor
Alternative name(s):
    Serotonin receptor 2B
Gene names
Name: 5-HT1B
Synonyms: 5HT-R2B
ORF Names: CG15113
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

CAA77571.1 sequence differs from that shown. Reason: Miscellaneous discrepancy. Chimeric DNA sequence.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 6176175-hydroxytryptamine receptor 2B

Regions

Topological domain1 – 9595Extracellular Potential
Transmembrane96 – 116211 Potential
Topological domain117 – 12812Cytoplasmic Potential
Transmembrane129 – 149212 Potential
Topological domain150 – 16415Extracellular Potential
Transmembrane165 – 185213 Potential
Topological domain186 – 20520Cytoplasmic Potential
Transmembrane206 – 226214 Potential
Topological domain227 – 25630Extracellular Potential
Transmembrane257 – 277215 Potential
Topological domain278 – 534257Cytoplasmic Potential
Transmembrane535 – 555216 Potential
Topological domain556 – 57015Extracellular Potential
Transmembrane571 – 591217 Potential
Topological domain592 – 61726Cytoplasmic Potential

Amino acid modifications

Glycosylation311N-linked (GlcNAc...) Potential
Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation581N-linked (GlcNAc...) Potential
Disulfide bond163 ↔ 242 By similarity

Experimental info

Sequence conflict611I → V in CAA77571. Ref.1
Sequence conflict3321T → M in CAA77571. Ref.1
Sequence conflict4241L → V in CAA77571. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P28286-1 [UniParc].

Last modified April 4, 2006. Version 3.
Checksum: DD0E1AB7706FD844

FASTA61767,530
        10         20         30         40         50         60 
MLKTVTTAMA AGDDDVPASI LEIELPAILL NESLFIELNG NLTQLVDTTS NLSQIVWNRS 

        70         80         90        100        110        120 
INGNGNSNTF DLVDDEQERA AVEFWLLVKM IAMAVVLGLM ILVTIIGNVF VIAAIILERN 

       130        140        150        160        170        180 
LQNVANYLVA SLAVADLFVA CLVMPLGAVY EISNGWILGP ELCDIWTSCD VLCCTASILH 

       190        200        210        220        230        240 
LVAIAADRYW TVTNIDYNNL RTPRRVFLMI FCVWFAALIV SLAPQFGWKD PDYMKRIEEQ 

       250        260        270        280        290        300 
HCMVSQDVGY QIFATCCTFY VPLLVILFLY WKIYIIARKR IQRRAQKSFN VTLTETDCDS 

       310        320        330        340        350        360 
AVRELKKERS KRRAERKRLE AGERTPVDGD GTGGQLQRRT RKRMRICFGR NTNTANVVAG 

       370        380        390        400        410        420 
SEGAVARSMA AIAVDFASLA ITREETEFST SNYDNKSHAG TELTTVSSDA DDYRTSNANE 

       430        440        450        460        470        480 
IITLSQQVAH ATQHHLIASH LNAITPLAQS IAMGGVGCLT TTTPSEKALS GAGTVAGAVA 

       490        500        510        520        530        540 
GGSGSGSGEE GAGTEGKNAG VGLGGVLASI ANPHQKLAKR RQLLEAKRER KAAQTLAIIT 

       550        560        570        580        590        600 
GAFVICWLPF FVMALTMSLC KECEIHTAVA SLFLWLGYFN STLNPVIYTI FNPEFRRAFK 

       610 
RILFGRKAAA RARSAKI

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References

« Hide 'large scale' references
[1]"A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns."
Saudou F., Boschert U., Amlaiky N., Plassat J.-L., Hen R.
EMBO J. 11:7-17(1992) [PubMed: 1310937] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Canton-S.
Tissue: Head.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.

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Cross-references

Sequence databases

Z11490 mRNA. Translation: CAA77571.1. Sequence problems.
AE013599 Genomic DNA. Translation: AAF57610.4.
PIRS19156.
RefSeqNP_523789.3.
UniGeneDm.2573

3D structure databases

HSSPHSSP built from PDB template 1HLL based on UniProtKB P08913.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblCG15113. Drosophila melanogaster. [Contig view]
GeneID37191.
KEGGdme:Dmel_CG15113.

Organism-specific databases

FlyBaseFBgn0004572. 5-HT1B.

Phylogenomic databases

HOGENOMP28286.

Gene expression databases

ArrayExpressP28286.
GermOnlineCG15113. Drosophila melanogaster.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomP28286.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry name5HT2B_DROME
AccessionPrimary (citable) accession number: P28286
Secondary accession number(s): Q9V8Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 4, 2006
Last modified: July 22, 2008
This is version 61 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents