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Reviewed, UniProtKB/Swiss-Prot P29017 (CD1C_HUMAN)

Last modified July 22, 2008. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    T-cell surface glycoprotein CD1c
Alternative name(s):
    CD_antigen=CD1c
Gene names
Name: CD1C
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Subunit structure

Heterodimer with B2M (beta-2-microglobulin).

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note= Subject to intracellular trafficking between the cell membrane and endosomes.

Tissue specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

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Ontologies

Keywords

   Biological processImmune response
   Cellular componentCell membrane
Endosome
Membrane
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Signal
Transmembrane
   PTMGlycoprotein

Gene Ontology (GO)

   Cellular componentintegral to plasma membrane

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 333316T-cell surface glycoprotein CD1c

Regions

Topological domain18 – 302285Extracellular Potential
Transmembrane303 – 32321 Potential
Topological domain324 – 33310Cytoplasmic Potential
Domain206 – 29691Ig-like
Motif329 – 3324Internalization signal

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential
Disulfide bond120 ↔ 185 By similarity
Disulfide bond225 ↔ 280 By similarity

Natural variations

Natural variant701N → T: dbSNP rs3138100.
Natural variant3001F → S: dbSNP rs3138105.

Experimental info

Sequence conflict2901Q → R in CAG33361. Ref.3
Sequence conflict327 – 3337CSYQDIL → W in AAA51942. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P29017-1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 8E4E057097E3E440

FASTA33337,654
        10         20         30         40         50         60 
MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL DELQTHGWDS 

        70         80         90        100        110        120 
ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ DHASQDYSKY PFEVQVKAGC 

       130        140        150        160        170        180 
ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL 

       190        200        210        220        230        240 
IRSTCPRFLL GLLDAGKMYV HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM 

       250        260        270        280        290        300 
RNEQEQLGTK HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF 

       310        320        330 
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL

« Hide

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References

« Hide 'large scale' references
[1]"Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c."
Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A.G., Milstein C.
Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed: 2447586] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts."
Aruffo A., Seed B.
J. Immunol. 143:1723-1730(1989) [PubMed: 2701945] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-300.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Polymorphism of human CD1 genes."
Han M., Hannick L.I., DiBrino M., Robinson M.A.
Tissue Antigens 54:122-127(1999) [PubMed: 10488738] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-109.
[7]"Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."
Martin L.H., Calabi F., Milstein C.
Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed: 3097645] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-296.
[8]"Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens."
Briken V., Jackman R.M., Watts G.F.M., Rogers R.A., Porcelli S.A.
J. Exp. Med. 192:281-288(2000) [PubMed: 10899914] [Abstract]
Cited for: FUNCTION, INTERNALIZATION SIGNAL, SUBCELLULAR LOCATION.
[9]"CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection."
Moody D.B., Ulrichs T., Muehlecker W., Young D.C., Gurcha S.S., Grant E., Rosat J.-P., Brenner M.B., Costello C.E., Besra G.S., Porcelli S.A.
Nature 404:884-888(2000) [PubMed: 10786796] [Abstract]
Cited for: FUNCTION.
[10]"CD1c molecules broadly survey the endocytic system."
Sugita M., van Der Wel N., Rogers R.A., Peters P.J., Brenner M.B.
Proc. Natl. Acad. Sci. U.S.A. 97:8445-8450(2000) [PubMed: 10890914] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

M22178 expand/collapse EMBL AC list , M22174, M22175, M22176, M22177 Genomic DNA. Translation: AAA51942.1.
M28827 mRNA. Translation: AAA51941.1.
CR457080 mRNA. Translation: CAG33361.1.
AL121986 Genomic DNA. Translation: CAI10850.1.
BC126465 mRNA. Translation: AAI26466.1.
BC126467 mRNA. Translation: AAI26468.1.
AF142667 Genomic DNA. Translation: AAD37580.1.
M14667 Genomic DNA. Translation: AAA51938.1.
PIRHLHUCC. C45801.
RefSeqNP_001756.2.
UniGeneHs.132448

3D structure databases

HSSPHSSP built from PDB template 1GZQ based on UniProtKB P29016.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000158481. Homo sapiens. [Contig view]
GeneID911.
KEGGhsa:911.
NMPDRfig|9606.3.peg.2363.

Organism-specific databases

H-InvDBHIX0028804.
HGNCHGNC:1636. CD1C.
MIM188340. gene.
PharmGKBPA26195.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENP29017.

Gene expression databases

ArrayExpressP29017.
CleanExHS_CD1C.
GermOnlineENSG00000158481. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProDomP29017.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubP29017.
SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameCD1C_HUMAN
AccessionPrimary (citable) accession number: P29017
Secondary accession number(s): Q5TDJ7 expand/collapse secondary AC list , Q6IAS4, Q9UMM0, Q9UN96
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 3, 2007
Last modified: July 22, 2008
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents