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Reviewed, UniProtKB/Swiss-Prot P29274 (AA2AR_HUMAN)

Last modified July 22, 2008. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine receptor A2a
Gene names
Name: ADORA2A
Synonyms: ADORA2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 412412Adenosine receptor A2a

Regions

Topological domain1 – 77Extracellular Potential
Transmembrane8 – 30231 Potential
Topological domain31 – 4313Cytoplasmic Potential
Transmembrane44 – 66232 Potential
Topological domain67 – 7711Extracellular Potential
Transmembrane78 – 100233 Potential
Topological domain101 – 12020Cytoplasmic Potential
Transmembrane121 – 143234 Potential
Topological domain144 – 17330Extracellular Potential
Transmembrane174 – 198255 Potential
Topological domain199 – 23436Cytoplasmic Potential
Transmembrane235 – 258246 Potential
Topological domain259 – 2668Extracellular Potential
Transmembrane267 – 290247 Potential
Topological domain291 – 412122Cytoplasmic Potential

Amino acid modifications

Glycosylation1541N-linked (GlcNAc...) Potential
Disulfide bond77 ↔ 166 By similarity

Natural variations

Natural variant501A → V: dbSNP rs4530.
Natural variant3001R → H: dbSNP rs4990.
Natural variant3921G → R

Secondary structure

1 ................................. 412
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P29274-1 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: 9438E9D64A6BE61B

FASTA41244,707
        10         20         30         40         50         60 
MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI 

        70         80         90        100        110        120 
PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR 

       130        140        150        160        170        180 
AKGIIAICWV LSFAIGLTPM LGWNNCGQPK EGKNHSQGCG EGQVACLFED VVPMNYMVYF 

       190        200        210        220        230        240 
NFFACVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG 

       250        260        270        280        290        300 
LFALCWLPLH IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR 

       310        320        330        340        350        360 
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS APHPERRPNG 

       370        380        390        400        410 
YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL DDPLAQDGAG VS

« Hide

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References

« Hide 'large scale' references
[1]Tiffany H.L., Murphy P.M.
Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]Salvatore C.A., Luneau C.J., Johnson R.G., Jacobson M.
Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Molecular characterization of a human brain adenosine A2 receptor."
Furlong T.J., Pierce K.D., Selbie L.A., Shine J.
Brain Res. Mol. Brain Res. 15:62-66(1992) [PubMed: 1331670] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[4]"Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A."
Le F., Townsend-Nicholson A., Baker E., Sutherland G.R., Schofield P.R.
Biochem. Biophys. Res. Commun. 223:461-467(1996) [PubMed: 8670304] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[9]"Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor."
Kim J., Wess J., van Rhee A.M., Schoneberg T., Jacobson K.A.
J. Biol. Chem. 270:13987-13997(1995) [PubMed: 7775460] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF TRANSMEMBRANE DOMAINS.
[10]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed: 10391209] [Abstract]
Cited for: VARIANT VAL-50.
[11]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)

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Cross-references

Sequence databases

M97370 mRNA. Translation: AAA58356.1. Different initiation.
X68486 mRNA. Translation: CAA48504.1.
S46950 mRNA. Translation: AAB23956.1.
U40771, U40770 Genomic DNA. Translation: AAA83270.1.
AY136747 mRNA. Translation: AAN01273.1.
BT006999 mRNA. Translation: AAP35645.1.
CR456367 mRNA. Translation: CAG30253.1.
BC013780 mRNA. Translation: AAH13780.1.
PIRA48978.
RefSeqNP_000666.2.
UniGeneHs.197029
Hs.700816

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1MMHmodel-16-36[»]
242-69[»]
378-102[»]
4117-143[»]
5175-203[»]
6233-260[»]
7264-296[»]
1UPEmodel-A1-304[»]
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP29274.

Genome annotation databases

EnsemblENSG00000128271. Homo sapiens. [Contig view]
GeneID135.
KEGGhsa:135.

Organism-specific databases

HGNCHGNC:263. ADORA2A.
MIM102776. gene.
PharmGKBPA24584.
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMP29274.
HOVERGENP29274.

Enzyme and pathway databases

ReactomeREACT_11061. Signalling by NGF.

Gene expression databases

ArrayExpressP29274.
CleanExHS_ADORA2A.
GermOnlineENSG00000128271. Homo sapiens.

Family and domain databases

InterProIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomP29274.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

DrugBankDB00201. Caffeine.
DB04932. Defibrotide.
DB00061. Pegademase bovine.
DB00277. Theophylline.
SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameAA2AR_HUMAN
AccessionPrimary (citable) accession number: P29274
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 1, 1994
Last modified: July 22, 2008
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents