Reviewed, UniProtKB/Swiss-Prot P29276 (AA2BR_RAT)

Names and origin

Protein names

Recommended name:
    Adenosine receptor A2b

Gene names

Name:

Adora2b

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 332	332	Adenosine receptor A2b
Regions
	Topological domain	1 – 8	8	Extracellular Potential
	Transmembrane	9 – 31	23	1 Potential
	Topological domain	32 – 44	13	Cytoplasmic Potential
	Transmembrane	45 – 67	23	2 Potential
	Topological domain	68 – 78	11	Extracellular Potential
	Transmembrane	79 – 101	23	3 Potential
	Topological domain	102 – 121	20	Cytoplasmic Potential
	Transmembrane	122 – 144	23	4 Potential
	Topological domain	145 – 178	34	Extracellular Potential
	Transmembrane	179 – 203	25	5 Potential
	Topological domain	204 – 235	32	Cytoplasmic Potential
	Transmembrane	236 – 259	24	6 Potential
	Topological domain	260 – 267	8	Extracellular Potential
	Transmembrane	268 – 291	24	7 Potential
	Topological domain	292 – 332	41	Cytoplasmic Potential
Amino acid modifications
	Lipidation	311	1	S-palmitoyl cysteine Potential
	Glycosylation	153	1	N-linked (GlcNAc...) Potential
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Disulfide bond	78 ↔ 171		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P29276-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: F0ABAB5CCACA8858	FASTA	332	36,367
	10 20 30 40 50 60 MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA TADVAVGLFA 70 80 90 100 110 120 IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA VDRYLAIRVP LRYKGLVTGT 130 140 150 160 170 180 RARGIIAVLW VLAFGIGLTP FLGWNSKDRA TSNCTEPGDG ITNKSCCPVK CLFENVVPMS 190 200 210 220 230 240 YMVYFNFFGC VLPPLLIMMV IYIKIFMVAC KQLQHMELME HSRTTLQREI HAAKSLAMIV 250 260 270 280 290 300 GIFALCWLPV HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS 310 320 330 FHRIISRYVL CQTDTKGGSG QAGGQSTFSL SL

References

[1]	"Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype." Stehle J.H., Rivkees S.A., Lee J.J., Weaver D.R., Deeds J.D., Reppert S.M. Mol. Endocrinol. 6:384-393(1992) [PubMed: 1584214] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"RFL9 encodes an A2b-adenosine receptor." Rivkees S.A., Reppert S.M. Mol. Endocrinol. 6:1598-1604(1992) [PubMed: 1333049] [Abstract] Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M91466 mRNA. Translation: AAA20981.1.
PIR	A42171.
RefSeq	NP_058857.1.
UniGene	Rn.89544
3D structure databases
HSSP	HSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSRNOG00000002922. Rattus norvegicus. [Contig view]
GeneID	29316.
KEGG	rno:29316.
Organism-specific databases
RGD	2050. Adora2b.
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	P29276.
Gene expression databases
ArrayExpress	P29276.
GermOnline	ENSRNOG00000002922. Rattus norvegicus.
Family and domain databases
InterPro	IPR001435. Adeno_A2B_rcpt. IPR001634. Adenosn_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00554. ADENOSINA2BR. PR00424. ADENOSINER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	P29276. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

AA2BR_RAT

Accession

Primary (citable) accession number: P29276

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	July 22, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)