Homeobox protein Hox-A2 - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot P31245 (HXA2_MOUSE)

Last modified September 2, 2008. Version 64. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A2
Alternative name(s):
    Hox-1.11
      Short name=Hox1.11

Gene names

Name:	Hoxa2
Synonyms:	Hox-1.11, Hoxa-2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Proboscipedia subfamily.

Contains 1 homeobox DNA-binding domain.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	anterior/posterior pattern formation Inferred from mutant phenotype. Source: MGI brain segmentation Inferred from mutant phenotype. Source: MGI cell fate determination Inferred from mutant phenotype. Source: MGI dorsal/ventral pattern formation Inferred from genetic interaction. Source: MGI embryonic viscerocranium morphogenesis Inferred from mutant phenotype. Source: MGI middle ear morphogenesis Inferred from mutant phenotype. Source: MGI motor axon guidance Inferred from mutant phenotype. Source: MGI negative regulation of neuron differentiation Inferred from genetic interaction. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI osteoblast development Inferred from genetic interaction. Source: MGI rhombomere 2 development Inferred from mutant phenotype. Source: MGI rhombomere 3 morphogenesis Inferred from mutant phenotype. Source: MGI segment specification Inferred from mutant phenotype. Source: MGI
Cellular component	nucleus Inferred from direct assay. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: MGI
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

1 – 372

372

Homeobox protein Hox-A2

Regions

DNA binding

139 – 198

Homeobox

Motif

96 – 101

Antp-type hexapeptide

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Sequences

Sequence

Length

Mass (Da)

Tools

P31245-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 0ADA79113DB72726
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FASTA

372

40,793

        10         20         30         40         50         60 
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 

        70         80         90        100        110        120 
PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM KEKKAAKKTA LPPAAASTGP 

       130        140        150        160        170        180 
ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE 

       190        200        210        220        230        240 
RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL 

       250        260        270        280        290        300 
EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 

       310        320        330        340        350        360 
CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI SADSFDFFTD 

       370 
TLTTIDLQHL NY

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of mouse Hox 1-11." Gridley T. Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Murine Hox-1.11 homeobox gene structure and expression." Tan D.P., Ferrante J., Nazarali A., Shao X., Kozak C.A., Guo V., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:6280-6284(1992) [PubMed: 1352886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: ICR X Swiss Webster.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[4]	"Hox-1.11 and Hox-4.9 homeobox genes." Nazarali A., Kim Y., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992) [PubMed: 1348361] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231. Strain: ICR X Swiss Webster.
[5]	"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies." Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372. Strain: HMI/Msf.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	M95599 mRNA. Translation: AAA37827.1. M93148 Genomic DNA. Translation: AAA37835.1. M93292 mRNA. Translation: AAA37836.1. BC117105 mRNA. Translation: AAI17106.1. BC117107 mRNA. Translation: AAI17108.1. M87801 Genomic DNA. Translation: AAA37834.1. AB039191 Genomic DNA. Translation: BAB68715.1.
PIR	A42694. A46037.
RefSeq	NP_034581.1.
UniGene	Mm.131
3D structure databases
HSSP	HSSP built from PDB template 1B72 based on UniProtKB P14653.
SMR	P31245. Positions 141-197.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000014704. Mus musculus. [Contig view]
GeneID	15399.
KEGG	mmu:15399.
Organism-specific databases
MGI	MGI:96174. Hoxa2.
Phylogenomic databases
HOGENOM	P31245.
HOVERGEN	P31245.
Gene expression databases
ArrayExpress	P31245.
CleanEx	MM_HOXA2.
GermOnline	ENSMUSG00000014704. Mus musculus.
Family and domain databases
InterPro	IPR001827. Antennapedia. IPR001356. Homeobox. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

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Entry information

Entry name

HXA2_MOUSE

Accession

Primary (citable) accession number: P31245
Secondary accession number(s): Q149U3, Q920T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	September 2, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents