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Reviewed, UniProtKB/Swiss-Prot P31268 (HXA7_HUMAN)

Last modified September 2, 2008. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Homeobox protein Hox-A7
Alternative name(s):
    Hox-1A
    Hox 1.1
Gene names
Name: HOXA7
Synonyms: HOX1A
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein

Gene Ontology (GO)

   Molecular functiontranscription factor activity Ref.2

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 230230Homeobox protein Hox-A7

Regions

DNA binding130 – 18960Homeobox
Motif119 – 1246Antp-type hexapeptide
Compositional bias157 – 1604Poly-Arg
Compositional bias196 – 1994Poly-Ala
Compositional bias214 – 23017Asp/Glu-rich (highly acidic)
Compositional bias223 – 2308Poly-Glu

Natural variations

Natural variant181T → A: dbSNP rs2301721.

Experimental info

Sequence conflict75 – 762DA → RR in AAD00727. Ref.6
Sequence conflict781Missing in CAA59270. Ref.4
Sequence conflict1741I → V in AAD01939. Ref.3
Sequence conflict194 – 1952PT → RL in CAA59270. Ref.4
Sequence conflict1951T → I Ref.7
Sequence conflict2221D → Y in CAA59270. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P31268-1 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 6E2F1991F1BBED21

FASTA23025,385
        10         20         30         40         50         60 
MSSSYYVNAL FSKYTAGTSL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP 

        70         80         90        100        110        120 
LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY 

       130        140        150        160        170        180 
PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN 

       190        200        210        220        230 
RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE

« Hide

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References

« Hide 'large scale' references
[1]"Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation."
La Celle P.T., Polakowska R.R.
J. Biol. Chem. 276:32844-32853(2001) [PubMed: 11435435] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1."
McIlhatton M.A., Bremner P.S., McMullin M.F., Maxwell A.P., Winter P.C., Lappin T.R.
Biochim. Biophys. Acta 1442:329-333(1998) [PubMed: 9804983] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Sequence analysis and tissue specific expression of human HOXA7."
Kim M.H., Jin H., Seol E.Y., Yoo M., Park H.W.
Mol. Biotechnol. 14:19-24(2000) [PubMed: 10911612] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]Albrechtsen R., Wewer U.
Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed: 12853948] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-18.
[6]Cho M., Kim M.H., Hwang C.Y., Min W.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91.
[7]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed: 2576652] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-195.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF026397 mRNA. Translation: AAB94604.1.
AJ005814 mRNA. Translation: CAA06713.1.
AF032095 Genomic DNA. Translation: AAD01939.2.
X84803, X84804 Genomic DNA. Translation: CAA59270.1.
AC004080 Genomic DNA. No translation available.
U92543 Genomic DNA. Translation: AAD00727.1.
PIRS15536.
RefSeqNP_008827.2.
UniGeneHs.660918

3D structure databases

HSSPHSSP built from PDB template 9ANT based on UniProtKB P02833.
SMRP31268. Positions 130-193.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000122592. Homo sapiens. [Contig view]
GeneID3204.
KEGGhsa:3204.

Organism-specific databases

H-InvDBHIX0033523.
HGNCHGNC:5108. HOXA7.
MIM142950. gene.
PharmGKBPA29385.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP31268.
HOVERGENP31268.

Gene expression databases

ArrayExpressP31268.
CleanExHS_HOXA7.
GermOnlineENSG00000122592. Homo sapiens.

Family and domain databases

InterProIPR001827. Antennapedia.
IPR001356. Homeobox.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
ProDomPD000010. Homeobox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameHXA7_HUMAN
AccessionPrimary (citable) accession number: P31268
Secondary accession number(s): O43368 expand/collapse secondary AC list , O43486, O95655, Q9NSC8, Q9UDM1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 15, 1998
Last modified: September 2, 2008
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents