Reviewed, UniProtKB/Swiss-Prot P34883 (MTAB_SYNP2)

Names and origin

Protein names

Recommended name:
    Modification methylase AquI subunit beta
      Short name=M.AquI subunit beta
      Short name=M.AquIB
    EC=2.1.1.37
Alternative name(s):
    Cytosine-specific methyltransferase AquI subunit beta

Gene names

Name:	aquIMB
Ordered Locus Names:	SYNPCC7002_A1188.1

Organism

Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) [Complete proteome] [HAMAP]

Taxonomic identifier

32049 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This methylase recognizes the double-stranded sequence CYCGRG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the AquI endonuclease.
Catalytic activity	S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
Subunit structure	Heterodimer of an alpha and a beta subunit.
Domain	Corresponds to the C-terminal half of the enzymatic domain.
Sequence similarities	Belongs to the C5-methyltransferase family.

Ontologies

Keywords
Biological process	Restriction system
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 139	139	Modification methylase AquI subunit beta

Sequences

	Sequence		Length	Mass (Da)
	P34883-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 8550B7E0194CE006	FASTA	139	15,760
	10 20 30 40 50 60 MDIKNVHIKN HEQTAHAPST LEKIRKVKQG GKLSEQTKTF GSTYRRLDPN QPSPTVTRSG 70 80 90 100 110 120 YRDFIHPFED RMLTVRELAC LQTFPLDWEF TGTRLDSYSS KRKVTMTQFG QVGNAVPPLL 130 AEAVAKAVSE QLLDVIDEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Agmenellum quadruplicatum M.AquI, a novel modification methylase." Karreman C., de Waard A. J. Bacteriol. 172:266-272(1990) [PubMed: 2104605] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of Synechococcus sp. PCC 7002." Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M28051 Genomic DNA. Translation: AAA22068.1. CP000951 Genomic DNA. No translation available.
3D structure databases
HSSP	HSSP built from PDB template 1DCT based on UniProtKB P20589.
ModBase	Search...
Protein family/group databases
REBASE	3283. M.AquI.
Organism-specific databases
CMR	Search...
Family and domain databases
InterPro	IPR001525. C5_DNA_meth. [Graphical view]
PANTHER	PTHR10629. C5_DNA_meth. 1 hit.
Pfam	PF00145. DNA_methylase. 1 hit. [Graphical view]
PROSITE	PS00095. C5_MTASE_2. 1 hit. [Graphical view]
ProDom	P34883. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MTAB_SYNP2

Accession

Primary (citable) accession number: P34883

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	September 2, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)