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Reviewed, UniProtKB/Swiss-Prot P34970 (AA1R_RABIT)

Last modified July 22, 2008. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine receptor A1
Gene names
Name: ADORA1
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

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Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate

Gene Ontology (GO)

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 328328Adenosine receptor A1

Regions

Topological domain1 – 1010Extracellular Potential
Transmembrane11 – 33231 Potential
Topological domain34 – 4613Cytoplasmic Potential
Transmembrane47 – 69232 Potential
Topological domain70 – 8011Extracellular Potential
Transmembrane81 – 102223 Potential
Topological domain103 – 12321Cytoplasmic Potential
Transmembrane124 – 146234 Potential
Topological domain147 – 17630Extracellular Potential
Transmembrane177 – 201255 Potential
Topological domain202 – 23534Cytoplasmic Potential
Transmembrane236 – 259246 Potential
Topological domain260 – 2678Extracellular Potential
Transmembrane268 – 292257 Potential
Topological domain293 – 32836Cytoplasmic Potential

Amino acid modifications

Lipidation3091S-palmitoyl cysteine Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Disulfide bond80 ↔ 169 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P34970-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 0F9B53E6AEC25968

FASTA32836,556
        10         20         30         40         50         60 
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 

        70         80         90        100        110        120 
LVIPLAILIN IGPETYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKAVVT 

       130        140        150        160        170        180 
PRRAAVAIAG CWILSLVVGL TPMFGWNNLR EVQRAWAANG SVGEPVIKCE FEKVISMEYM 

       190        200        210        220        230        240 
VYFNFFVWVL PPLLLMVLIY LEVFYLIRRQ LSKKASASSG DPHKYYGKEL KIAKSLALIL 

       250        260        270        280        290        300 
FLFALSWLPL HILNCVTLFC PSCQKPSILV YTAIFLTHGN SAMNPIVYAF RIHKFRVTFL 

       310        320 
KIWNDHFRCR PAPAGDGDED LPEEKPND

« Hide

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References

[1]"Cloning of an adenosine A1 receptor-encoding gene from rabbit."
Bhattacharya S., Dewitt D.L., Burnatowska-Hledin M., Smith W.L., Spielman W.S.
Gene 128:285-288(1993) [PubMed: 8514195] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

L01700 mRNA. Translation: AAA31148.1.
PIRJN0675.

3D structure databases

HSSPHSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSOCUG00000011017. Oryctolagus cuniculus. [Contig view]

Phylogenomic databases

HOVERGENP34970.

Family and domain databases

InterProIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PANTHERPTHR19266:SF15. Adeno_A1_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomP34970.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameAA1R_RABIT
AccessionPrimary (citable) accession number: P34970
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 22, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents