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Reviewed, UniProtKB/Swiss-Prot P34996 (P2RY1_CHICK)

Last modified September 2, 2008. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    P2Y purinoceptor 1
      Short name=P2Y1
Alternative name(s):
    Purinergic receptor
    ATP receptor
Gene names
Name: P2RY1
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

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Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for extracellular adenine nucleotides such as ATP and ADP. Seems to mediate its action via a pertussis toxin insensitive G-protein, probably belonging to the Gq family that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Brain, spinal cord, gastrointestinal tract, spleen and leg muscle. Is not detected in the heart, liver, stomach, lung and kidney.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical term3D-structure

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 362362P2Y purinoceptor 1

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 63221 Potential
Topological domain64 – 7613Cytoplasmic Potential
Transmembrane77 – 98222 Potential
Topological domain99 – 11517Extracellular Potential
Transmembrane116 – 136213 Potential
Topological domain137 – 15519Cytoplasmic Potential
Transmembrane156 – 177224 Potential
Topological domain178 – 20730Extracellular Potential
Transmembrane208 – 227205 Potential
Topological domain228 – 25427Cytoplasmic Potential
Transmembrane255 – 274206 Potential
Topological domain275 – 29218Extracellular Potential
Transmembrane293 – 317257 Potential
Topological domain318 – 36245Cytoplasmic Potential

Amino acid modifications

Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Disulfide bond113 ↔ 191 By similarity

Secondary structure

1 ................. 362
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P34996-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: A806C88FB9514761

FASTA36241,194
        10         20         30         40         50         60 
MTEALISAAL NGTQPELLAG GWAAGNATTK CSLTKTGFQF YYLPTVYILV FITGFLGNSV 

        70         80         90        100        110        120 
AIWMFVFHMR PWSGISVYMF NLALADFLYV LTLPALIFYY FNKTDWIFGD VMCKLQRFIF 

       130        140        150        160        170        180 
HVNLYGSILF LTCISVHRYT GVVHPLKSLG RLKKKNAVYV SSLVWALVVA VIAPILFYSG 

       190        200        210        220        230        240 
TGVRRNKTIT CYDTTADEYL RSYFVYSMCT TVFMFCIPFI VILGCYGLIV KALIYKDLDN 

       250        260        270        280        290        300 
SPLRRKSIYL VIIVLTVFAV SYLPFHVMKT LNLRARLDFQ TPQMCAFNDK VYATYQVTRG 

       310        320        330        340        350        360 
LASLNSCVDP ILYFLAGDTF RRRLSRATRK SSRRSEPNVQ SKSEEMTLNI LTEYKQNGDT 


SL

« Hide

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References

[1]"Cloning and functional expression of a brain G-protein-coupled ATP receptor."
Webb T.E., Simon J., Krishek B.J., Bateson A.N., Smart T.G., King B.F., Burnstock G., Barnard E.A.
FEBS Lett. 324:219-225(1993) [PubMed: 8508924] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Modelling the P2Y purinoceptor using rhodopsin as template."
van Rhee A.M., Fischer B., van Galen P.J.M., Jacobson K.A.
Drug Des. Discov. 13:133-140(1995) [PubMed: 8872457] [Abstract]
Cited for: 3D-STRUCTURE MODELING.

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Cross-references

Sequence databases

X73268 mRNA. Translation: CAA51716.1.
PIRS33733.
RefSeqNP_990664.1.
UniGeneGga.5306

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1DDDmodel-140-70[»]
276-103[»]
3114-138[»]
4153-179[»]
5204-232[»]
6249-276[»]
7289-321[»]
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSGALG00000010357. Gallus gallus. [Contig view]
GeneID396275.
KEGGgga:396275.

Phylogenomic databases

HOGENOMP34996.
HOVERGENP34996.

Family and domain databases

InterProIPR001277. CXC_4_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR002286. P2_purnocptor.
IPR000142. P2Y_purnocptor.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00645. CXCCHMKINER4.
PR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PR01157. P2YPURNOCPTR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomP34996.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameP2RY1_CHICK
AccessionPrimary (citable) accession number: P34996
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 2, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents