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Reviewed, UniProtKB/Swiss-Prot P35191 (MDJ1_YEAST)

Last modified July 22, 2008. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    DnaJ homolog 1, mitochondrial
Gene names
Name: MDJ1
Ordered Locus Names: YFL016C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Plays a role in mitochondrial biogenesis and protein folding.

Subcellular location

Mitochondrion.

Miscellaneous

Present with 7570 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 CR-type zinc finger.

Contains 1 J domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Transit peptide1 – 5555Mitochondrion Potential
Chain56 – 511456DnaJ homolog 1, mitochondrial

Regions

Domain59 – 12769J
Repeat230 – 2378CXXCXGXG motif
Repeat247 – 2548CXXCXGXG motif
Repeat269 – 2768CXXCXGXG motif
Repeat285 – 2928CXXCXGXG motif
Zinc finger217 – 29781CR-type
Compositional bias130 – 18657Gly-rich

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Sequences

Sequence LengthMass (Da)Tools
P35191-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 007343427C66D2B6

FASTA51155,561
        10         20         30         40         50         60 
MAFQQGVLSR CSGVFRHHVG HSRHINNILY RHAIAFASIA PRIPKSSFHT SAIRNNEAFK 

        70         80         90        100        110        120 
DPYDTLGLKK SATGAEIKKA YYKLAKKYHP DINKEPDAEK KFHDLQNAYE ILSDETKRQQ 

       130        140        150        160        170        180 
YDQFGPAAFG GGGAAGGAGG GSGSPFGSQF HDFSGFTSAG GSPFGGINFE DLFGAAFGGG 

       190        200        210        220        230        240 
GRGSGGASRS SSMFRQYRGD PIEIVHKVSF KDAVFGSKNV QLRFSALDPC STCSGTGMKP 

       250        260        270        280        290        300 
NTHKVSCSTC HGTGTTVHIR GGFQMMSTCP TCNGEGTMKR PQDNCTKCHG EGVQVNRAKT 

       310        320        330        340        350        360 
ITVDLPHGLQ DGDVVRIPGQ GSYPDIAVEA DLKDSVKLSR GDILVRIRVD KDPNFSIKNK 

       370        380        390        400        410        420 
YDIWYDKEIP ITTAALGGTV TIPTVEGQKI RIKVAPGTQY NQVISIPNMG VPKTSTIRGD 

       430        440        450        460        470        480 
MKVQYKIVVK KPQSLAEKCL WEALADVTND DMAKKTMQPG TAAGTAINEE ILKKQKQEEE 

       490        500        510 
KHAKKDDDNT LKRLENFITN TFRKIKGDKK N

« Hide

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References

« Hide 'large scale' references
[1]Rowley N.K., Prip-Buus C., Westermann B., Brown C.M., Schwarz E., Barrell B.G., Neupert W.
Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Barrell B.G., Churcher C., Rajandream M.A.
Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[4]"Mdj1p, a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding."
Rowley N., Prip-Buus C., Westermann B., Brown C., Schwarz E., Barrell B., Neupert W.
Cell 77:249-259(1994) [PubMed: 8168133] [Abstract]
Cited for: FUNCTION.
[5]"Purification and biochemical properties of Saccharomyces cerevisiae Mdj1p, the mitochondrial DnaJ homologue."
Deloche O., Liberek K., Zylicz M., Georgopoulos C.
J. Biol. Chem. 272:28539-28544(1997) [PubMed: 9353316] [Abstract]
Cited for: FUNCTION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z28336 Genomic DNA. Translation: CAA82189.1.
Z46255 Genomic DNA. Translation: CAA86351.1.
D50617 Genomic DNA. Translation: BAA09222.1.
PIRS38898.
RefSeqNP_116638.1.

3D structure databases

HSSPHSSP built from PDB template 1BQZ based on UniProtKB P08622.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:764N.
IntActP35191.

Proteomic databases

PeptideAtlasP35191.

Genome annotation databases

EnsemblYFL016C. Saccharomyces cerevisiae. [Contig view]
GeneID850530.
GenomeReviewsGene locus YFL016C in contig D50617_GR.
KEGGsce:YFL016C.
NMPDRfig|4932.3.peg.2266.

Organism-specific databases

CYGDYFL016c.
SGDS000001878. MDJ1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP35191.

Gene expression databases

GermOnlineYFL016C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002939. DnaJ_C.
IPR001623. DnaJ_N.
IPR015609. Hsp40/DnaJ_Rel.
IPR003095. Hsp_DnaJ.
IPR001305. HSP_DnaJ_cys-rich.
[Graphical view]
Gene3DG3DSA:1.10.287.110. DnaJ_N. 1 hit.
G3DSA:2.10.230.10. HSP_DnaJ_cys-rich. 1 hit.
PANTHERPTHR11821. Hsp40/DnaJ_Rel. 1 hit.
PfamPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSPR00625. DNAJPROTEIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]
ProDomP35191.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubP35191.
ProtoNetSearch...

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Entry information

Entry nameMDJ1_YEAST
AccessionPrimary (citable) accession number: P35191
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 22, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents