Reviewed, UniProtKB/Swiss-Prot P35454 (NEU1_MOUSE)

Names and origin

Protein names

Recommended name:
    Oxytocin-neurophysin 1
      Short name(s)=OT-NPI
Cleaved into 2 chains:
  Recommended name:
      Oxytocin
  Alternative name(s):
      Ocytocin
  Recommended name:
      Neurophysin 1

Gene names

Name:

Oxt

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
Sequence similarities	Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Gene Ontology (GO)
Cellular component	extracellular region Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Peptide	20 – 28	9	Oxytocin
	Chain	32 – 125	94	Neurophysin 1
Amino acid modifications
	Modified residue	28	1	Glycine amide By similarity
	Disulfide bond	20 ↔ 25		By similarity
	Disulfide bond	41 ↔ 85		By similarity
	Disulfide bond	44 ↔ 58		By similarity
	Disulfide bond	52 ↔ 75		By similarity
	Disulfide bond	59 ↔ 65		By similarity
	Disulfide bond	92 ↔ 104		By similarity
	Disulfide bond	98 ↔ 116		By similarity
	Disulfide bond	105 ↔ 110		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35454-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 96D3135EBBA2436E	FASTA	125	12,851
	10 20 30 40 50 60 MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG RCFGPSICCA 70 80 90 100 110 120 DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA TGICCSPDGC RTDPACDPES AFSER

References

[1]	"Structure of mouse vasopressin and oxytocin genes." Hara Y., Battey J., Gainer H. Brain Res. Mol. Brain Res. 8:319-324(1990) [PubMed: 2176709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"High-throughput sequence identification of gene coding variants within alcohol-related QTLs." Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M. Mamm. Genome 12:657-663(2001) [PubMed: 11471062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ILS and ISS.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M88355 Genomic DNA. Translation: AAC42024.1. AF483508 mRNA. Translation: AAL90782.1. AF483509 mRNA. Translation: AAL90783.1.
PIR	A43755.
RefSeq	NP_035155.1.
UniGene	Mm.16745
3D structure databases
HSSP	HSSP built from PDB template 1L5C based on UniProtKB P01175.
SMR	P35454. Positions 32-123.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000027301. Mus musculus. [Contig view]
GeneID	18429.
KEGG	mmu:18429.
Organism-specific databases
MGI	MGI:97453. Oxt.
Phylogenomic databases
HOGENOM	P35454.
HOVERGEN	P35454.
Gene expression databases
ArrayExpress	P35454.
CleanEx	MM_OXT.
GermOnline	ENSMUSG00000027301. Mus musculus.
Family and domain databases
InterPro	IPR000981. Neurhyp_horm. IPR016321. Nonapeptide_hormone_prcur. [Graphical view]
Gene3D	G3DSA:2.60.9.10. Neurhyp_horm. 1 hit.
Pfam	PF00220. Hormone_4. 1 hit. PF00184. Hormone_5. 1 hit. [Graphical view]
PIRSF	PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTS	PR00831. NEUROPHYSIN.
ProDom	PD001676. Neurhyp_horm. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00003. NH. 1 hit. [Graphical view]
PROSITE	PS00264. NEUROHYPOPHYS_HORM. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

NEU1_MOUSE

Accession

Primary (citable) accession number: P35454

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	July 22, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)