Reviewed, UniProtKB/Swiss-Prot P36206 (DBH_THEMA)

Names and origin

Protein names

Recommended name:
    DNA-binding protein HU

Gene names

Name:	hup
Ordered Locus Names:	TM_0266

Organism

Thermotoga maritima [Complete proteome] [HAMAP]

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Sequence similarities	Belongs to the bacterial histone-like protein family.

Ontologies

Keywords
Biological process	DNA condensation
Ligand	DNA-binding
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	mitotic chromosome condensation Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 90

90

DNA-binding protein HU

PRO_0000104989

Experimental info

Sequence conflict

2

1

T → N in AAA27416. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

90

Helix Strand Turn

Details...

Helix

3 – 14

12

Helix

18 – 37

20

Beta strand

42 – 44

3

Turn

45 – 47

3

Beta strand

48 – 51

4

Beta strand

78 – 81

4

Helix

83 – 89

7

Sequences

	Sequence		Length	Mass (Da)
	P36206-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 7C5F31A262DD60D6	FASTA	90	9,980
	10 20 30 40 50 60 MTKKELIDRV AKKAGAKKKD VKLILDTILE TITEALAKGE KVQIVGFGSF EVRKAAARKG 70 80 90 VNPQTRKPIT IPERKVPKFK PGKALKEKVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The histone-like protein (HU) of Thermotoga maritima." Markiewicz P.G., Ehret S., Miller J.H. Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[3]	"Cloning, overproduction, purification and crystallization of the DNA binding protein HU from the hyperthermophilic eubacterium Thermotoga maritima." Christodoulou E., Vorgias C.E. Acta Crystallogr. D 54:1043-1045(1998) [PubMed: 9757133] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Cross-references

Sequence databases

EMBLGenBankDDBJ

L23541 Genomic DNA. Translation: AAA27416.1.
AE000512 Genomic DNA. Translation: AAD35355.1.

PIR

H72396.

RefSeq

NP_228079.1.

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B8Z	X-ray	1.60	A/B	1-90	[»]
1RIY	X-ray	1.80	A	1-90	[»]

ModBase

Search...

Genome annotation databases

GeneID

897177.

GenomeReviews

Gene locus TM_0266 in contig AE000512_GR.

KEGG

tma:TM0266.

NMPDR

fig|243274.1.peg.263.

TIGR

TM_0266.

Phylogenomic databases

HOGENOM

P36206.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_0266-MON.

Family and domain databases

InterPro

IPR000119. Hist_DNA_bd_bac.
[Graphical view]

Gene3D

G3DSA:4.10.520.10. Hist_DNA_bd_bac. 1 hit.

Pfam

PF00216. Bac_DNA_binding. 1 hit.
[Graphical view]

PRINTS

PR01727. DNABINDINGHU.

ProDom

PD000945. Bac_DNAbind. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00411. BHL. 1 hit.
[Graphical view]

PROSITE

PS00045. HISTONE_LIKE. 1 hit.
[Graphical view]

BLOCKS

Search...

ProtoNet

Search...

Entry information

Entry name

DBH_THEMA

Accession

Primary (citable) accession number: P36206

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	May 30, 2000
Last modified:	November 4, 2008
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)