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P36556

- BASR_SALTY

UniProt

P36556 - BASR_SALTY

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Protein
Transcriptional regulatory protein BasR
Gene
basR, parA, pmrA, STM4292
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.2 Publications

GO - Molecular functioni

  1. DNA bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pathogenesisInferred from electronic annotationi Source: UniProtKB-KW
  2. regulation of transcription, DNA-templatedInferred from electronic annotationi Source: UniProtKB-KW
  3. response to antibioticInferred from electronic annotationi Source: UniProtKB-KW
  4. transcription, DNA-templatedInferred from electronic annotationi Source: UniProtKB-KW
  1. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Antibiotic resistance, Transcription, Transcription regulation, Two-component regulatory system, Virulence

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein BasR
Gene namesi
Name:basR
Synonyms:parA, pmrA
Ordered Locus Names:STM4292
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasmInferred from electronic annotationi Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi51 – 511D → A: No activation of BasR regulated genes. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Transcriptional regulatory protein BasR
PRO_0000081024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 5114-aspartylphosphate

Post-translational modificationi

Phosphorylated by BasS.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP36556.
PRIDEiP36556.

Expressioni

Inductioni

The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.4 Publications

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi99287.STM4292.

Structurei

3D structure databases

ProteinModelPortaliP36556.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 116116Response regulatory
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
KOiK07771.
OMAiACDCAGT.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36556-1 [UniParc]FASTA

« Hide

MKILIVEDDT LLLQGLILAA QTEGYACDGV STARAAEHSL ESGHYSLMVL    50
DLGLPDEDGL HFLTRIRQKK YTLPVLILTA HDTLNDRITG LDVGADDYLV 100
KPFALEELHA RIRALLRRHN NQGESELTVG NLTLNIGRHQ AWRDGQELTL 150
TPKEYALLSR LMLKAGSPVH REILYNDIYN WDNEPSTNTL EVHIHNLRDK 200
VGKSRIRTVR GFGYMLVATE ES 222
Length:222
Mass (Da):25,035
Last modified:June 1, 1994 - v1
Checksum:i3734CC2034070533
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811H → R in strain: LT2 / SGSC1412 and S4194; resistance to polymyxin B and neutrophil proteins.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13395 Genomic DNA. Translation: AAA72365.1.
AY725348 Genomic DNA. Translation: AAV92795.1.
AE006468 Genomic DNA. Translation: AAL23116.1.
PIRiB40656.
RefSeqiNP_463157.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23116; AAL23116; STM4292.
GeneIDi1255818.
KEGGistm:STM4292.
PATRICi32387493. VBISalEnt20916_4514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13395 Genomic DNA. Translation: AAA72365.1 .
AY725348 Genomic DNA. Translation: AAV92795.1 .
AE006468 Genomic DNA. Translation: AAL23116.1 .
PIRi B40656.
RefSeqi NP_463157.1. NC_003197.1.

3D structure databases

ProteinModelPortali P36556.
ModBasei Search...

Protein-protein interaction databases

STRINGi 99287.STM4292.

Proteomic databases

PaxDbi P36556.
PRIDEi P36556.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL23116 ; AAL23116 ; STM4292 .
GeneIDi 1255818.
KEGGi stm:STM4292.
PATRICi 32387493. VBISalEnt20916_4514.

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034815.
KOi K07771.
OMAi ACDCAGT.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-4323-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publicationsDownload
  1. "Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence."
    Roland K.L., Martin L.E., Esther C.R., Spitznagel J.K.
    J. Bacteriol. 175:4154-4164(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. "Phenotypic differences between Salmonella and Escherichia coli resulting from the disparate regulation of homologous genes."
    Winfield M.D., Groisman E.A.
    Proc. Natl. Acad. Sci. U.S.A. 101:17162-17167(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], REGULATION BY PMRD.
    Strain: S4194.
  3. "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
    McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.
    , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
    Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  4. "PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance."
    Gunn J.S., Miller S.I.
    J. Bacteriol. 178:6857-6864(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION.
    Strain: ATCC 14028s / SGSG 2262.
  5. "Molecular characterization of the PmrA regulon."
    Woesten M.M.S.M., Groisman E.A.
    J. Biol. Chem. 274:27185-27190(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, PHOSPHORYLATION, SUBUNIT.
    Strain: ATCC 14028s / SGSG 2262.
  6. "A small protein that mediates the activation of a two-component system by another two-component system."
    Kox L.F.F., Woesten M.M.S.M., Groisman E.A.
    EMBO J. 19:1861-1872(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASP-51, PHOSPHORYLATION AT ASP-51.
    Strain: ATCC 14028s / SGSG 2262.
  7. "Closing the loop: the PmrA/PmrB two-component system negatively controls expression of its posttranscriptional activator PmrD."
    Kato A., Latifi T., Groisman E.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:4706-4711(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, REGULATION BY PMRD.
    Strain: ATCC 14028s / SGSG 2262.

Entry nameiBASR_SALTY
AccessioniPrimary (citable) accession number: P36556
Secondary accession number(s): Q5MN92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The activity of the BasR protein is controlled at a post-transcriptional level by the PmrD protein, under low Mg2+ concentration conditions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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