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P36557

- BASS_SALTY

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Protein
Sensor protein BasS
Gene
basS, parB, pmrB, STM4291

Gene:

basS, parB, pmrB, STM4291
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - - Experimental evidence at protein leveli

UniProt

P36557 - BASS_SALTY

Protein:

Sensor protein BasS
Protein Existence: Experimental evidence at protein level

Functioni

Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  1. ATP bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay sensor kinase activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ATP bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay sensor kinase activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system, Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4322-MONOMER.
BRENDAi2.7.13.3. 5542.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein BasS (EC:2.7.13.3)
Gene namesi
Name:basS
Synonyms:parB, pmrB
Ordered Locus Names:STM4291
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Topological domaini1 – 1313Cytoplasmic Reviewed prediction
Transmembranei14 – 3421Helical; Reviewed prediction
Topological domaini35 – 6430Periplasmic Reviewed prediction
Transmembranei65 – 8824Helical; Reviewed prediction
Topological domaini89 – 356268Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membraneInferred from electronic annotationi Source: UniProtKB-KW
  2. plasma membraneInferred from electronic annotationi Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Chaini1 – 356356Sensor protein BasS
PRO_0000074702

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Modified residuei1521Phosphohistidine; by autocatalysis By similarity

Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP36557.
PRIDEiP36557.

Expressioni

Inductioni

The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4291.

Structurei

3D structure databases

ProteinModelPortaliP36557.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Domaini89 – 14153HAMP
Domaini149 – 356208Histidine kinase

Sequence similaritiesi

Contains 1 HAMP domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000127051.
KOiK07643.
OMAiMSRTAIG.
OrthoDBiEOG6G4VQG.
ProtClustDBiPRK10755.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36557-1 [UniParc]FASTA

« Hide

MRFQRRAMTL RQRLMLTIGL ILLVFQLIST FWLWHESTEQ IQLFEQALRD    50
NRNNDRHIMH EIREAVASLI VPGVFMVSLT LLICYQAVRR ITRPLAELQK 100
ELEARTADNL APIAIHSSTL EIESVVSAIN QLVTRLTTTL DNERLFTADV 150
AHELRTPLSG VRLHLELLSK THNVDVAPLI ARLDQMMDSV SQLLQLARVG 200
QSFSSGNYQE VKLLEDVILP SYDELNTMLE TRQQTLLLPE SAADVVVRGD 250
ATLLRMLLRN LVENAHRYSP EGTHITIHIS ADPDAIMAVE DEGPGIDESK 300
CGKLSEAFVR MDSRYGGIGL GLSIVSRITQ LHQGQFFLQN RTERTGTRAW 350
VLLKKA 356
Length:356
Mass (Da):40,262
Last modified:June 1, 1994 - v1
Checksum:i953234B125727BBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13395 Genomic DNA. Translation: AAA72366.1.
AE006468 Genomic DNA. Translation: AAL23115.1.
PIRiC40656.
RefSeqiNP_463156.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23115; AAL23115; STM4291.
GeneIDi1255817.
KEGGistm:STM4291.
PATRICi32387491. VBISalEnt20916_4513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13395 Genomic DNA. Translation: AAA72366.1 .
AE006468 Genomic DNA. Translation: AAL23115.1 .
PIRi C40656.
RefSeqi NP_463156.1. NC_003197.1.

3D structure databases

ProteinModelPortali P36557.
ModBasei Search...

Protein-protein interaction databases

STRINGi 99287.STM4291.

Proteomic databases

PaxDbi P36557.
PRIDEi P36557.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL23115 ; AAL23115 ; STM4291 .
GeneIDi 1255817.
KEGGi stm:STM4291.
PATRICi 32387491. VBISalEnt20916_4513.

Phylogenomic databases

eggNOGi COG0642.
HOGENOMi HOG000127051.
KOi K07643.
OMAi MSRTAIG.
OrthoDBi EOG6G4VQG.
ProtClustDBi PRK10755.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-4322-MONOMER.
BRENDAi 2.7.13.3. 5542.

Family and domain databases

Gene3Di 1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view ]
Pfami PF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view ]
PRINTSi PR00344. BCTRLSENSOR.
SMARTi SM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view ]
SUPFAMi SSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publicationsDownload
  1. "Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence."
    Roland K.L., Martin L.E., Esther C.R., Spitznagel J.K.
    J. Bacteriol. 175:4154-4164(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
    McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.
    , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
    Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Molecular characterization of the PmrA regulon."
    Woesten M.M.S.M., Groisman E.A.
    J. Biol. Chem. 274:27185-27190(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, AUTOPHOSPHORYLATION.
    Strain: ATCC 14028s / SGSG 2262.

Entry nameiBASS_SALTY
AccessioniPrimary (citable) accession number: P36557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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