Reviewed, UniProtKB/Swiss-Prot P37299 (QCR10_YEAST)

Names and origin

Protein names

Recommended name:
    Cytochrome b-c1 complex subunit 10
Alternative name(s):
    Ubiquinol-cytochrome c reductase complex 8.5 kDa protein
    Complex III subunit 10
    Complex III subunit XI

Gene names

Name:	QCR10
Ordered Locus Names:	YHR001W-A
ORF Names:	YHR001BW

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	77 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR10 is required for stable association of the iron-sulfur protein with the complex.
Subunit structure	Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.
Subcellular location	Mitochondrion inner membrane.
Miscellaneous	Present with 5590 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the UQCR11/QCR10 family.
Sequence caution	The sequence AAB68434.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	aerobic respiration Ref.1 Inferred from genetic interaction. Source: SGD mitochondrial electron transport, ubiquinol to cytochrome c Ref.1 Inferred from mutant phenotype. Source: SGD
Cellular component	mitochondrial respiratory chain complex III Ref.1 Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 77	76	Cytochrome b-c1 complex subunit 10		PRO_0000193563
Regions
	Transmembrane	25 – 45	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P37299-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: B9212B4FD194BB3E	FASTA	77	8,593
	10 20 30 40 50 60 MAYTSHLSSK TGLHFGRLSL RSLTAYAPNL MLWGGASMLG LFVFTEGWPK FQDTLYKKIP 70 LLGPTLEDHT PPEDKPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex." Brandt U., Uribe S., Schaegger H., Trumpower B.L. J. Biol. Chem. 269:12947-12953(1994) [PubMed: 8175712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Point mutation in cytochrome b of yeast ubihydroquinone:cytochrome-c oxidoreductase causing myxothiazol resistance and facilitated dissociation of the iron-sulfur subunit." Geier B.M., Schaegger H., Brandt U., Colson A.-M., von Jagow G. Eur. J. Biochem. 208:375-380(1992) [PubMed: 1325905] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-29 AND 38-59. Strain: GM50-3C.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U07275 Unassigned DNA. Translation: AAA19322.1. U10555 Genomic DNA. Translation: AAB68434.1. Sequence problems.
PIR	A53768.
RefSeq	NP_011864.1.
3D structure databases
ModBase	Search...
Proteomic databases
PeptideAtlas	P37299.
Genome annotation databases
Ensembl	YHR001W-A. Saccharomyces cerevisiae. [Contig view]
GeneID	856390.
GenomeReviews	Gene locus YHR001W-A in contig U00093_GR.
KEGG	sce:YHR001W-A.
NMPDR	fig|4932.3.peg.3008.
Organism-specific databases
CYGD	YHR001w-a.
SGD	S000003529. QCR10.
Phylogenomic databases
HOGENOM	P37299.
Gene expression databases
GermOnline	YHR001W-A. Saccharomyces cerevisiae.
Family and domain databases
BLOCKS	Search...
ProtoNet	Search...
Other Resources
LinkHub	P37299.
NextBio	981902.

Entry information

Entry name

QCR10_YEAST

Accession

Primary (citable) accession number: P37299
Secondary accession number(s): O13538, Q9T2W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	January 23, 2007
Last modified:	November 4, 2008
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)