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P37478

- YYCF_BACSU

UniProt

P37478 - YYCF_BACSU

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Protein
Transcriptional regulatory protein YycF
Gene
yycF, BSU40410
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - - Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter sequence in vitro. YycF has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA.3 Publications

GO - Molecular functioni

  1. DNA bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templatedInferred from mutant phenotypei PubMed 10878122 Source: CACAO
  2. transcription, DNA-templatedInferred from electronic annotationi Source: UniProtKB-KW
  1. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU40410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein YycF
Gene namesi
Name:yycF
Ordered Locus Names:BSU40410
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU40410.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasmInferred from electronic annotationi Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Mutagenesisi53 – 531D → H: Constitutively active. 1 Publication
Mutagenesisi215 – 2151H → P in JH17041; thermosensitive; decrease in dimerization and DNA-binding. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Chaini1 – 235235Transcriptional regulatory protein YycF
PRO_0000081399

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Modified residuei53 – 5314-aspartylphosphate Inferred

Post-translational modificationi

Phosphorylated by YycG Inferred.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP37478.

Expressioni

Developmental stagei

Expressed during exponential growth and shut down at the entry into stationary phase.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi224308.BSU40410.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Beta strandi4 – 85
Helixi12 – 2413
Beta strandi28 – 347
Helixi35 – 439
Beta strandi48 – 536
Turni57 – 593
Helixi60 – 6910
Beta strandi76 – 838
Helixi85 – 939
Beta strandi98 – 1036
Helixi106 – 11712
Beta strandi135 – 1373
Beta strandi140 – 1434
Turni144 – 1474
Beta strandi148 – 1514
Helixi160 – 17112
Turni172 – 1743
Helixi179 – 1879
Helixi196 – 20914
Beta strandi217 – 2226
Turni223 – 2253
Beta strandi226 – 2294

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D1VX-ray2.40A128-235[»]
2ZWMX-ray2.04A/B1-122[»]
3F6PX-ray1.95A1-120[»]
ProteinModelPortaliP37478.
SMRiP37478. Positions 1-120, 131-233.

Miscellaneous databases

EvolutionaryTraceiP37478.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Domaini4 – 117114Response regulatory

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
KOiK07668.
OMAiHEILSYG.
OrthoDBiEOG6G4VQG.
PhylomeDBiP37478.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37478-1 [UniParc]FASTA

« Hide

MDKKILVVDD EKPIADILEF NLRKEGYEVH CAHDGNEAVE MVEELQPDLI    50
LLDIMLPNKD GVEVCREVRK KYDMPIIMLT AKDSEIDKVI GLEIGADDYV 100
TKPFSTRELL ARVKANLRRQ LTTAPAEEEP SSNEIHIGSL VIFPDAYVVS 150
KRDETIELTH REFELLHYLA KHIGQVMTRE HLLQTVWGYD YFGDVRTVDV 200
TVRRLREKIE DNPSHPNWIV TRRGVGYYLR NPEQD 235
Length:235
Mass (Da):27,226
Last modified:October 1, 1994 - v1
Checksum:i201BC21CBB5EC6B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26185 Genomic DNA. Translation: BAA05173.1.
D78193 Genomic DNA. Translation: BAA11300.1.
AL009126 Genomic DNA. Translation: CAB16078.1.
PIRiS65967.
RefSeqiNP_391921.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB16078; CAB16078; BSU40410.
GeneIDi937776.
KEGGibsu:BSU40410.
PATRICi18980160. VBIBacSub10457_4242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26185 Genomic DNA. Translation: BAA05173.1 .
D78193 Genomic DNA. Translation: BAA11300.1 .
AL009126 Genomic DNA. Translation: CAB16078.1 .
PIRi S65967.
RefSeqi NP_391921.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D1V X-ray 2.40 A 128-235 [» ]
2ZWM X-ray 2.04 A/B 1-122 [» ]
3F6P X-ray 1.95 A 1-120 [» ]
ProteinModelPortali P37478.
SMRi P37478. Positions 1-120, 131-233.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224308.BSU40410.

Proteomic databases

PaxDbi P37478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB16078 ; CAB16078 ; BSU40410 .
GeneIDi 937776.
KEGGi bsu:BSU40410.
PATRICi 18980160. VBIBacSub10457_4242.

Organism-specific databases

GenoListi BSU40410.

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034819.
KOi K07668.
OMAi HEILSYG.
OrthoDBi EOG6G4VQG.
PhylomeDBi P37478.

Enzyme and pathway databases

BioCyci BSUB:BSU40410-MONOMER.

Miscellaneous databases

EvolutionaryTracei P37478.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publicationsDownload
  1. "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin."
    Ogasawara N., Nakai S., Yoshikawa H.
    DNA Res. 1:1-14(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "Sequence analysis of the 36-kb region between gntZ and trnY genes of Bacillus subtilis genome."
    Kasahara Y., Nakai S., Ogasawara N.
    DNA Res. 4:155-159(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy."
    Fabret C., Hoch J.A.
    J. Bacteriol. 180:6375-6383(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF HIS-215.
    Strain: 168 / JH642.
  5. "The essential two-component regulatory system encoded by yycF and yycG modulates expression of the ftsAZ operon in Bacillus subtilis."
    Fukuchi K., Kasahara Y., Asai K., Kobayashi K., Moriya S., Ogasawara N.
    Microbiology 146:1573-1583(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ASP-53.
    Strain: 168.
  6. "Molecular characterization of the essential response regulator protein YycF in Bacillus subtilis."
    Watanabe T., Hashimoto Y., Umemoto Y., Tatebe D., Furuta E., Fukamizo T., Yamamoto K., Utsumi R.
    J. Mol. Microbiol. Biotechnol. 6:155-163(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF HIS-215, SUBUNIT.
  7. "Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach."
    Howell A., Dubrac S., Andersen K.K., Noone D., Fert J., Msadek T., Devine K.
    Mol. Microbiol. 49:1639-1655(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STUDY OF THE YYCF/YYCG REGULON.
  8. "The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis."
    Bisicchia P., Noone D., Lioliou E., Howell A., Quigley S., Jensen T., Jarmer H., Devine K.M.
    Mol. Microbiol. 65:180-200(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry nameiYYCF_BACSU
AccessioniPrimary (citable) accession number: P37478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

External Data

Dasty 3

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