Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot P38700 (APM2_YEAST)

Last modified November 4, 2008. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Adaptin medium chain homolog APM2
Alternative name(s):
    Adaptin-mu1-II
Gene names
Name: APM2
Ordered Locus Names: YHL019C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Hide | Top

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Subunit structure

Interacts with APL2, probably forming an alternative AP-1-like complex.

Subcellular location

Membrane › coated pit.

Miscellaneous

Present with 2890 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the adaptor complexes medium subunit family.

Contains 1 MHD (mu homology) domain.

Hide | Top

Ontologies

Keywords

   Cellular componentCoated pit
Membrane
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processGolgi to vacuole transport

Inferred from mutant phenotype. Source: SGD

   Cellular componentAP-1 adaptor complex Ref.4

Inferred from physical interaction. Source: SGD

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

APL2P360002EBI-2705,EBI-2206

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 605605Adaptin medium chain homolog APM2
PRO_0000193793

Regions

Domain266 – 605340MHD

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P38700-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 7E216B11325EEE3C

FASTA60569,990
        10         20         30         40         50         60 
MSSSLFILDE NLEPLVSKNI RALPNLSSVL SSFKQCYHDG SPPILSQNDW FFIHLKRDFL 

        70         80         90        100        110        120 
HFVSVIHTTD KPNIDLMTIL AFLEQFYHLL QKYFEIEVLT KNVILDNILL VLELIDECID 

       130        140        150        160        170        180 
FGIVQVTDPS IIKDYIRVKV NVPRVTVDNE EWSPGEESSS SSGSDSDSEY SNTNKRKDKK 

       190        200        210        220        230        240 
KKRKKKKGTK GKSVGKSKLK SIMVNNKENR GINVVETVKE TLRNKNDTGK EAANDELPND 

       250        260        270        280        290        300 
GNDLYINGDI AKTIIMPISW RTKGIHYAKN EFFLDVIERV QYLMDFEKGV IRKNLIHGEI 

       310        320        330        340        350        360 
VCRCYLSGMP KLKISINKIL NRDPQFMSNS SFHQCVSLDS INTIEKDEEK NSDDDAGLQA 

       370        380        390        400        410        420 
ATDAREIEFI PPDGEFVLCQ YELKRHVKDA PMVRLKDFEI KPKLKKFKIQ IVTKIQTNFK 

       430        440        450        460        470        480 
PTNSTSKLNV RIPLTKVFQE YKIDLSKQIR FKANIGKVVF NLSDDFLLWE IQTMKGHREH 

       490        500        510        520        530        540 
STNKSSQYNS DEDDPNTCAS MVAEFPLFNQ EEYDRLQEEM KTSMNPPPLR TGPRLEELYR 

       550        560        570        580        590        600 
QVHDQQTSHV TPRDKLVNID FEIPYCTCSG LKVEYLKVEE PQLQYQSFPW VRYKTVSDEE 


YAYIV

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein."
Stepp J.D., Pellicena-Palle A., Hamilton S., Kirchhausen T., Lemmon S.K.
Mol. Biol. Cell 6:41-58(1995) [PubMed: 7749194] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / REE526.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"Adaptor complex-independent clathrin function in yeast."
Yeung B.G., Phan H.L., Payne G.S.
Mol. Biol. Cell 10:3643-3659(1999) [PubMed: 10564262] [Abstract]
Cited for: INTERACTION WITH APL2.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

U09841 Genomic DNA. Translation: AAA83415.1.
U11582 Genomic DNA. Translation: AAB65072.1.
PIRS46833.
RefSeqNP_011844.1.

3D structure databases

HSSPHSSP built from PDB template 1H6E based on UniProtKB P20172.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1200N.
IntActP38700.

Genome annotation databases

EnsemblYHL019C. Saccharomyces cerevisiae. [Contig view]
GeneID856367.
GenomeReviewsGene locus YHL019C in contig U00093_GR.
KEGGsce:YHL019C.
NMPDRfig|4932.3.peg.2983.

Organism-specific databases

CYGDYHL019c.
SGDS000001011. APM2.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP38700.

Gene expression databases

ArrayExpressP38700.
GermOnlineYHL019C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001392. Clathrin_mu.
IPR008968. Clathrin_mu_C.
[Graphical view]
PfamPF00928. Adap_comp_sub. 1 hit.
[Graphical view]
PROSITEPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

LinkHubP38700.
NextBio981837.

Hide | Top

Entry information

Entry nameAPM2_YEAST
AccessionPrimary (citable) accession number: P38700
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 4, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents