Reviewed, UniProtKB/Swiss-Prot P40197 (GPV_HUMAN)

Names and origin

Protein names

Recommended name:
    Platelet glycoprotein V
      Short name=GPV
Alternative name(s):
    CD_antigen=CD42D

Gene names

Name:

GP5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The GPIb-V-IX complex functions as the von Willebrand factor receptor and mediates von Willebrand factor-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Platelets and megakaryocytes.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Contains 14 LRR (leucine-rich) repeats.

Ontologies

Keywords
Biological process	Blood coagulation Cell adhesion
Cellular component	Membrane
Domain	Leucine-rich repeat Repeat Signal Transmembrane
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell adhesion Ref.1 Non-traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc platelet alpha granule membrane Inferred from Experiment. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 560	544	Platelet glycoprotein V
Regions
	Topological domain	17 – 523	507	Extracellular Potential
	Transmembrane	524 – 544	21	Potential
	Topological domain	545 – 560	16	Cytoplasmic Potential
	Repeat	73 – 96	24	LRR 1
	Repeat	97 – 120	24	LRR 2
	Repeat	122 – 144	23	LRR 3
	Repeat	145 – 168	24	LRR 4
	Repeat	169 – 192	24	LRR 5
	Repeat	194 – 216	23	LRR 6
	Repeat	217 – 240	24	LRR 7
	Repeat	241 – 264	24	LRR 8
	Repeat	266 – 288	23	LRR 9
	Repeat	289 – 312	24	LRR 10
	Repeat	314 – 337	24	LRR 11
	Repeat	338 – 361	24	LRR 12
	Repeat	362 – 385	24	LRR 13
	Repeat	386 – 409	24	LRR 14
Amino acid modifications
	Glycosylation	51	1	N-linked (GlcNAc...)
	Glycosylation	181	1	N-linked (GlcNAc...)
	Glycosylation	243	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
	Glycosylation	298	1	N-linked (GlcNAc...)
	Glycosylation	312	1	N-linked (GlcNAc...)
	Glycosylation	385	1	N-linked (GlcNAc...)
	Glycosylation	499	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	130	1	D → W AA sequence Ref.3
	Sequence conflict	136 – 138	3	GID → PGG AA sequence Ref.3
	Sequence conflict	267	1	N → H AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P40197-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: B1CDB04AF8AF7115	FASTA	560	60,959
	10 20 30 40 50 60 MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT NLTHILLFGM 70 80 90 100 110 120 GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL KTLRLSRNKI THLPGALLDK 130 140 150 160 170 180 MVLLEQLFLD HNALRGIDQN MFQKLVNLQE LALNQNQLDF LPASLFTNLE NLKLLDLSGN 190 200 210 220 230 240 NLTHLPKGLL GAQAKLERLL LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR 250 260 270 280 290 300 LPNLSSLTLS RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT 310 320 330 340 350 360 QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG LTALPDGLLR 370 380 390 400 410 420 GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE TLPGDVFGAL PRLTEVLLGH 430 440 450 460 470 480 NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR CAGPGAHAGL PLWALPGGDA ECPGPRGPPP 490 500 510 520 530 540 RPAADSSSEA PVHPALAPNS SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV 550 560 FAMIKIGQLF RKLIRERALG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins." Hickey M.J., Hagen F.S., Yagi M., Roth G.J. Proc. Natl. Acad. Sci. U.S.A. 90:8327-8331(1993) [PubMed: 7690959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation." Lanza F., Morales M., de la Salle C., Cazenave J.-P., Clemetson K.J., Shimomura T., Phillips D.R. J. Biol. Chem. 268:20801-20807(1993) [PubMed: 8407908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Platelet.
[3]	"Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib." Shimomura T., Fujimura K., Maehama S., Takemoto M., Oda K., Fujimoto T., Oyama R., Suzuki M., Icihara-Tanaka K., Titani K., Kuramoto A. Blood 75:2349-2356(1990) [PubMed: 2350580] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Platelet.
[4]	"Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion." Roth G.J., Church T.A., McMullen B.A., Williams S.A. Biochem. Biophys. Res. Commun. 170:153-161(1990) [PubMed: 2372284] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Platelet.
[5]	"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach." Lewandrowski U., Moebius J., Walter U., Sickmann A. Mol. Cell. Proteomics 5:226-233(2006) [PubMed: 16263699] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-181, MASS SPECTROMETRY. Tissue: Platelet.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L11238 mRNA. Translation: AAA03069.1. Z23091 Genomic DNA. Translation: CAA80637.1.
PIR	A60164. A48030.
RefSeq	NP_004479.1.
UniGene	Hs.73734
3D structure databases
HSSP	HSSP built from PDB template 1M0Z based on UniProtKB P07359.
ModBase	Search...
Proteomic databases
PeptideAtlas	P40197.
Genome annotation databases
Ensembl	ENSG00000178732. Homo sapiens. [Contig view]
GeneID	2814.
KEGG	hsa:2814.
Organism-specific databases
H-InvDB	HIX0030879.
HGNC	HGNC:4443. GP5.
MIM	173511. gene.
PharmGKB	PA24474.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P40197.
HOVERGEN	P40197.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	P40197.
CleanEx	HS_GP5.
GermOnline	ENSG00000178732. Homo sapiens.
Family and domain databases
InterPro	IPR001611. LRR. IPR000483. LRR_C. IPR000372. LRR_cys_N. IPR003591. LRR_sub-typ. [Graphical view]
Pfam	PF00560. LRR_1. 11 hits. PF01463. LRRCT. 1 hit. [Graphical view]
PRINTS	PR00019. LEURICHRPT.
SMART	SM00369. LRR_TYP. 9 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
ProDom	P40197. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

GPV_HUMAN

Accession

Primary (citable) accession number: P40197

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	July 22, 2008
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)