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Reviewed, UniProtKB/Swiss-Prot P40890 (VTH2_YEAST)

Last modified November 25, 2008. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein VTH2
Alternative name(s):
    VPS10 homolog 2
Gene names
Name: VTH2
Ordered Locus Names: YJL222W
ORF Names: J0213, HRC1549
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length1549 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Acts as a vacuolar sorting receptor for proteins like the carboxypeptidase Y.

Subcellular location

Membrane; Single-pass membrane proteinPotential.

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the PEP1 family.

Contains 12 BNR repeats.

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Ontologies

Keywords

   Biological processProtein transport
Transport
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processGolgi to vacuole transport Ref.3

Inferred from genetic interaction. Source: SGD

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functionreceptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

signal sequence binding Ref.3

Inferred from genetic interaction. Source: SGD

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 15491528Protein VTH2
PRO_0000014331

Regions

Transmembrane1370 – 139021 Potential
Repeat57 – 6812BNR 1
Repeat101 – 11212BNR 2
Repeat159 – 17012BNR 3
Repeat228 – 23912BNR 4
Repeat393 – 40412BNR 5
Repeat465 – 47612BNR 6
Repeat511 – 52212BNR 7
Repeat740 – 75112BNR 8
Repeat837 – 84812BNR 9
Repeat1040 – 105112BNR 10
Repeat1119 – 113012BNR 11
Repeat1160 – 117112BNR 12

Amino acid modifications

Glycosylation4791N-linked (GlcNAc...) Potential
Glycosylation7691N-linked (GlcNAc...) Potential
Glycosylation9861N-linked (GlcNAc...) Potential
Glycosylation14181N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
P40890-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: B260CF7C927B4E4F

FASTA1,549174,402
        10         20         30         40         50         60 
MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR AEEDSVEISF 

        70         80         90        100        110        120 
DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF YVTDDQGKSW RPLTIPISEK 

       130        140        150        160        170        180 
ASNYFCDVTT HPIKKKHLII RCDLLTIKNS GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG 

       190        200        210        220        230        240 
HISTARCDFI KSSEDSDLGG NDASILCLFR NTEYIESTGS TIDKSELILS ADGGETFKEL 

       250        260        270        280        290        300 
VQFKDKVVSR YEILKHHVIV LTQDDMYNEM SSTNIWISND VSTFQVARTP TKIRHVNMGQ 

       310        320        330        340        350        360 
IHEDSIGRIV LPVSRERDDE DSNQPGAAEV LISDSEGLKF LPINWIPNNQ FGYINVAYPG 

       370        380        390        400        410        420 
FLKGTFFGSF HPFIEYSDRK RKYSRQKVRE ETKVSVDNGL TWTNLKVVDR ENVDLFGCDV 

       430        440        450        460        470        480 
TKPERCSLQT HFYDLRNLNP SAGIMMISGI VGDGSAYNWK EEKTFISRDS GLTWRLVHNS 

       490        500        510        520        530        540 
TGLYTTGDLG NIIMYIPYRS NENGDVPSKF YYSLDQGKTW GEYDLIMPIY PYRLVSTISD 

       550        560        570        580        590        600 
GSGSKFILTG TSITEDPIFI TYSIDFSAVF DYKSCEEGDF EDWNLADGKC VNGAKYKYRR 

       610        620        630        640        650        660 
RKQDAQCLVK KAFKDLSLDE TPCNSCTGSD YECSFEFVRD AKGDCIPDYN LIALSDICDK 

       670        680        690        700        710        720 
SKGKSVLVKP LQLIKGDKCK TPMKIESVDI PCDEIPKEGS SDKEIVTTEN KFDFEIKFYQ 

       730        740        750        760        770        780 
YFDTVADESL VMLNSIGDAY ISHDGGQTIK RFDTDGEKIV EIVFNPYFNS SAYLFGSKGN 

       790        800        810        820        830        840 
IFLTHDRGYS FMIAKLPEAR QLGMPLDFSA KAQDTFIYYG GKNCESILSP ECHAVAYLTK 

       850        860        870        880        890        900 
DGGETFTEML DNAIHCEFAG TLFKYPSNDD MVMCQVKEKF SQTRSLVSST DFFQDDRKTV 

       910        920        930        940        950        960 
FENIIGYLST GGYIIVAVPH EDNELRAYVT NDGAEFTEAK FPYDEDIGKQ DAFTILGSEE 

       970        980        990       1000       1010       1020 
GSIFLHLATN LESGHDFGNL LKSNSNGTSF VTLEHAVNRN TFGYVDFEKV QGLEGIIITN 

      1030       1040       1050       1060       1070       1080 
IVSNSEKVGE NKEDEQLKTK ITFNDGSDWN FLKPPKKDSE GKKFPCDSVS LDKCSLHLHG 

      1090       1100       1110       1120       1130       1140 
YTERKDIRDT YSSGSALGMM FGVGNVGDRL LPYEECSTFL TTDGGETWTE VKKGPHQWEY 

      1150       1160       1170       1180       1190       1200 
GDHGGVLVLV PENAETDSIS YSTDFGKTWK DYKFCGDKVL VKDIITVPRD SALRFLLFGE 

      1210       1220       1230       1240       1250       1260 
AKNMGSGSFR TYTIDFRNIF ERQCEFDITG RKRADFKYSP LGSRTGCLFG HKTEFLRKTD 

      1270       1280       1290       1300       1310       1320 
EKCFIGNIPL SEFSRNVKNC PCTRQDFECD YNFYKASDGT CKLVKGLSSA NGADICKKEP 

      1330       1340       1350       1360       1370       1380 
DLIEYYDSSG YRKIPLSTCK GGLKLDAHLA PHPCPGKEKA FREKYSINTG AYALVFVTIL 

      1390       1400       1410       1420       1430       1440 
LVIFFVAWFV YDRGIRRNGG FSRFEEIRLG DDGLIENNRT DRVVNIIVRL GLCISLITKS 

      1450       1460       1470       1480       1490       1500 
AFQRAKAGTA QLSSKFRARF GNKKGATYSS LLHDQLSDEP DGFHEDSNDL SSFRGQGSNS 

      1510       1520       1530       1540 
EIEQEDVDTS QQEHTSRTDL LGASNIPDAL PARSASHESD LAAARSEDK

« Hide

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References

« Hide 'large scale' references
[1]"Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X."
Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.
Yeast 10:1657-1662(1994) [PubMed: 7725802] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Multiple pathways for vacuolar sorting of yeast proteinase A."
Westphal V., Marcusson E.G., Winther J.R., Emr S.D., van den Hazel H.B.
J. Biol. Chem. 271:11865-11870(1996) [PubMed: 8662642] [Abstract]
Cited for: FUNCTION.
[4]"Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases."
Cooper A.A., Stevens T.H.
J. Cell Biol. 133:529-541(1996) [PubMed: 8636229] [Abstract]
Cited for: FUNCTION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z34098 Genomic DNA. Translation: CAA83988.1.
Z49497 Genomic DNA. Translation: CAA89519.1.
PIRS50705.
RefSeqNP_012313.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6665N.

Genome annotation databases

EnsemblYJL222W. Saccharomyces cerevisiae. [Contig view]
GeneID853233.
GenomeReviewsGene locus YJL222W in contig Y13136_GR.
KEGGsce:YJL222W.

Organism-specific databases

CYGDYJL222w.
SGDS000003758. VTH2.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP40890.

Gene expression databases

GermOnlineYJL222W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002860. BNR.
IPR006581. VPS10.
[Graphical view]
PfamPF02012. BNR. 12 hits.
[Graphical view]
SMARTSM00602. VPS10. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubP40890.
NextBio973452.

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Entry information

Entry nameVTH2_YEAST
AccessionPrimary (citable) accession number: P40890
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 25, 2008
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents