Reviewed, UniProtKB/Swiss-Prot P41232 (P2RY2_RAT)

Names and origin

Protein names

Recommended name:
    P2Y purinoceptor 2
      Short name=P2Y2
Alternative name(s):
    P2U purinoceptor 1
      Short name=P2U1
    ATP receptor
    Purinergic receptor

Gene names

Name:	P2ry2
Synonyms:	P2ru1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 374	374	P2Y purinoceptor 2
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 59	27	1 Potential
	Topological domain	60 – 70	11	Cytoplasmic Potential
	Transmembrane	71 – 93	23	2 Potential
	Topological domain	94 – 110	17	Extracellular Potential
	Transmembrane	111 – 129	19	3 Potential
	Topological domain	130 – 152	23	Cytoplasmic Potential
	Transmembrane	153 – 172	20	4 Potential
	Topological domain	173 – 194	22	Extracellular Potential
	Transmembrane	195 – 220	26	5 Potential
	Topological domain	221 – 245	25	Cytoplasmic Potential
	Transmembrane	246 – 268	23	6 Potential
	Topological domain	269 – 286	18	Extracellular Potential
	Transmembrane	287 – 308	22	7 Potential
	Topological domain	309 – 374	66	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 183		By similarity
Experimental info
	Sequence conflict	132	1	C → S in AAA61565. Ref.1
	Sequence conflict	143	1	S → R in AAA61565. Ref.1
	Sequence conflict	166	1	A → T in AAA61565. Ref.1
	Sequence conflict	188	1	A → D in AAA61565. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P41232-1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 2DA6853AA20A1AF3	FASTA	374	42,137
	10 20 30 40 50 60 MAAGLDSWNS TINGTWEGDE LGYKCRFNED FKYVLLPVSY GVVCVLGLCL NVVALYIFLC 70 80 90 100 110 120 RLKTWNASTT YMFHLAVSDS LYAASLPLLV YYYAQGDHWP FSTVLCKLVR FLFYTNLYCS 130 140 150 160 170 180 ILFLTCISVH RCLGVLRPLH SLSWGHARYA RRVAAVVWVL VLACQAPVLY FVTTSVRGTR 190 200 210 220 230 240 ITCHDTSARE LFSHFVAYSS VMLGLLFAVP FSIILVCYVL MARRLLKPAY GTTGLPRAKR 250 260 270 280 290 300 KSVRTIALVL AVFALCFLPF HVTRTLYYSF RSLDLSCHTL NAINMAYKIT RPLASANSCL 310 320 330 340 350 360 DPVLYFLAGQ RLVRFARDAK PATEPTPSPQ ARRKLGLHRP NRTDTVRKDL SISSDDSRRT 370 ESTPAGSETK DIRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of the alveolar type II cell P2u-purinergic receptor." Rice W.R., Burton F.M., Fiedeldey D.T. Am. J. Respir. Cell Mol. Biol. 12:27-32(1995) [PubMed: 7811468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Chen Z.P., Krull N., Xu S., Levy A., Lightman S.L. Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Pituitary.
[3]	"Overexpression of P2Y2 purinoceptor in intimal lesions of the rat aorta." Seye C.I., Gadeau A.P., Daret D., Dupuch F., Alzieu P., Capron L., Desgranges C. Arterioscler. Thromb. Vasc. Biol. 17:3602-3610(1997) [PubMed: 9437211] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U09402 mRNA. Translation: AAA61565.1. L46865 mRNA. Translation: AAB02099.1. U56839 mRNA. Translation: AAC00048.1. BC061754 mRNA. Translation: AAH61754.1.
RefSeq	NP_058951.1.
UniGene	Rn.11102
3D structure databases
HSSP	HSSP built from PDB template 1DDD based on UniProtKB P34996.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P41232.
Genome annotation databases
Ensembl	ENSRNOG00000019283. Rattus norvegicus. [Contig view]
GeneID	29597.
KEGG	rno:29597.
Organism-specific databases
RGD	62088. P2ry2.
Phylogenomic databases
HOVERGEN	P41232.
Gene expression databases
ArrayExpress	P41232.
GermOnline	ENSRNOG00000019283. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002286. P2_purnocptor. IPR000356. P2U_purnocptor. [Graphical view]
PANTHER	PTHR19264:SF155. P2U_purnocptor. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00594. P2Y2PRNOCPTR. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	P41232. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

P2RY2_RAT

Accession

Primary (citable) accession number: P41232

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	October 1, 1996
Last modified:	September 2, 2008
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)