Reviewed, UniProtKB/Swiss-Prot P41986 (ACM4_BOVIN)

Names and origin

Protein names

Recommended name:
    Muscarinic acetylcholine receptor M4

Gene names

Name:

CHRM4

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	126 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. May couple to multiple functional responses in cell lines.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	‹1 – ›126	›126	Muscarinic acetylcholine receptor M4
Regions
	Topological domain	‹1 – ›126	›126	Cytoplasmic Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	126	1

Sequences

	Sequence		Length	Mass (Da)
	P41986-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 686D9D691B488ABB	FASTA	126	13,221
	10 20 30 40 50 60 MKQSVKKPPP PGDTTVRGEL PNGKLEEAPP PVLPPPPRPM ADKDTSNESS SGSATQNTKE 70 80 90 100 110 120 RPPTELSTTE ATTPATPAPP LQPRTLNPAS KWSKIQIVTK QTGNECVTAI EIVPATPAGM RPAANV

References

[1]	"Presence of multiple muscarinic receptor subtypes in bovine chromaffin cells - analysis by polymerase chain reaction." Sui A.-L., Chou W.-Y., Kao L.-S. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adrenal gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L27104 mRNA. Translation: AAA30654.1.
UniGene	Bt.89084
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Phylogenomic databases
HOVERGEN	P41986.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. [Graphical view]
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. Partial match. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACM4_BOVIN

Accession

Primary (citable) accession number: P41986

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	July 22, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)