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Reviewed, UniProtKB/Swiss-Prot P42884 (AAD14_YEAST)

Last modified November 25, 2008. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative aryl-alcohol dehydrogenase AAD14
    EC=1.1.1.-
Gene names
Name: AAD14
Ordered Locus Names: YNL331C
ORF Names: N0300
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Sequence similarities

Belongs to the aldo/keto reductase 2 family.

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Ontologies

Keywords

   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to toxin

Inferred from expression pattern. Source: SGD

   Molecular functionidentical protein binding

Inferred from physical interaction. Source: IntAct

oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-1994,EBI-1994
SRP1Q028211EBI-1994,EBI-1797

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Putative aryl-alcohol dehydrogenase AAD14
PRO_0000070369

Regions

Nucleotide binding236 – 24611NADP By similarity

Sites

Active site761Proton donor By similarity
Binding site1511Substrate By similarity
Site1031Lowers pKa of active site Tyr By similarity

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Sequences

Sequence LengthMass (Da)Tools
P42884-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2265406386938313

FASTA37641,991
        10         20         30         40         50         60 
MTDLFKPLPE PPTELGRLRV LSKTAGIRVS PLILGGASIG DAWSGFMGSM NKEQAFELLD 

        70         80         90        100        110        120 
AFYEAGGNCI DTANSYQNEE SEIWIGEWMA SRKLRDQIVI ATKFTGDYKK YEVGGGKSAN 

       130        140        150        160        170        180 
YCGNHKRSLH VSVRDSLRKL QTDWIDILYI HWWDYMSSIE EVMDSLHILV QQGKVLYLGV 

       190        200        210        220        230        240 
SDTPAWVVSA ANYYATSHGK TPFSVYQGKW NVLNRDFERD IIPMARHFGM ALAPWDVMGG 

       250        260        270        280        290        300 
GRFQSKKAME ERKKNGEGLR TFVGGPEQTE LEVKISEALT KIAEEHGTES VTAIAIAYVR 

       310        320        330        340        350        360 
SKAKNVFPLI GGRKIEHLKQ NIEALSIKLT PEQIEYLESI VPFDVGFPKS LIGDDPAVTK 

       370 
KLSPLTSMSA RIAFDN

« Hide

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References

« Hide 'large scale' references
[1]"An 8.2 kb DNA segment from chromosome XIV carries the RPD3 and PAS8 genes as well as the Saccharomyces cerevisiae homologue of the thiamine-repressed nmt1 gene and a chromosome III-duplicated gene for a putative aryl-alcohol dehydrogenase."
van Dyck L., Pascual-Ahuir A., Purnelle B., Goffeau A.
Yeast 11:987-991(1995) [PubMed: 8533474] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed: 9169873] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X83226 Genomic DNA. Translation: CAA58227.1.
Z71607 Genomic DNA. Translation: CAA96264.1.
PIRS51335.
RefSeqNP_014068.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:2146N.
IntActP42884.

Genome annotation databases

EnsemblYNL331C. Saccharomyces cerevisiae. [Contig view]
GeneID855385.
GenomeReviewsGene locus YNL331C in contig Y13139_GR.
KEGGsce:YNL331C.
NMPDRfig|4932.3.peg.5130.

Organism-specific databases

CYGDYNL331c.
SGDS000005275. AAD14.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP42884.

Gene expression databases

GermOnlineYNL331C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001395. Aldo/ket_red.
[Graphical view]
Gene3DG3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHERPTHR11732. Aldo/ket_red. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
ProDomPD000288. Aldo/ket_red. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

LinkHubP42884.
NextBio979184.

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Entry information

Entry nameAAD14_YEAST
AccessionPrimary (citable) accession number: P42884
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 25, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents