Reviewed, UniProtKB/Swiss-Prot P43095 (CARP6_CANAL)

Names and origin

Protein names

Recommended name:
    Candidapepsin-6
    EC=3.4.23.24
Alternative name(s):
    Aspartate protease 6
    ACP 6
    Secreted aspartic protease 6

Gene names

Name:

SAP6

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.
Subcellular location	Secreted.
Post-translational modification	O-glycosylated By similarity.
Sequence similarities	Belongs to the peptidase A1 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Aspartyl protease Hydrolase Protease
PTM	Cleavage on pair of basic residues Glycoprotein Zymogen
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 76	58	Activation peptide Potential
	Chain	77 – 418	342	Candidapepsin-6
Sites
	Active site	108	1	By similarity
	Active site	294	1	By similarity
Amino acid modifications
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Disulfide bond	123 ↔ 135		By similarity
	Disulfide bond	332 ↔ 370		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43095-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D32AAF203E096083	FASTA	418	45,469
	10 20 30 40 50 60 MFLKNILSVL RFALLIDAAP VKRSPGFVTL DFNVKRSLVV PDDPTAESKR SPLFLDLDPT 70 80 90 100 110 120 QIPVDDTGRN VGVDKRGPVA VKLDNEIITY SADITVGSNN QKLSVIVDTG SSDLWIPDSK 130 140 150 160 170 180 AICIPKWRGD CGDFCKNNGS YSPAASSTSK NLNTRFEIKY ADGSYAKGNL YQDTVGIGGA 190 200 210 220 230 240 SVKNQLFANV WSTSAHKGIL GIGFQTNEAT RTPYDNLPIS LKKQGIIAKN AYSLFLNSPE 250 260 270 280 290 300 ASSGQIIFGG IDKAKYSGSL VELPITSDRT LSVGLRSVNV MGRNVNVNAG VLLDSGTTIS 310 320 330 340 350 360 YFTPSIARSI IYALGGQVHF DSAGNKAYVA DCKTSGTVDF QFDKNLKISV PASEFLYQLY 370 380 390 400 410 YTNGKPYPKC EIRVRESEDN ILGDNFMRSA YIVYDLDDKK ISMAQVKYTS ESNIVAIN

References

[1]	"Multiplicity of genes encoding secreted aspartic proteinases in Candida species." Monod M., Togni G., Hube B., Sanglard D. Mol. Microbiol. 13:357-368(1994) [PubMed: 7984113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C74.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z30192 Genomic DNA. Translation: CAA82924.1.
PIR	S42073. S49057.
3D structure databases
HSSP	HSSP built from PDB template 1EAG based on UniProtKB P28871.
ModBase	Search...
Protein family/group databases
MEROPS	A01.064.
Family and domain databases
InterPro	IPR001969. Pept_Asp_AS. IPR009007. Pept_Aspartc_cat. IPR001461. Peptidase_A1. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit.
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF00026. Asp. 1 hit. [Graphical view]
PRINTS	PR00792. PEPSIN.
PROSITE	PS00141. ASP_PROTEASE. 2 hits. [Graphical view]
ProDom	P43095. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CARP6_CANAL

Accession

Primary (citable) accession number: P43095

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	July 22, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)