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Reviewed, UniProtKB/Swiss-Prot P43564 (YFD4_YEAST)

Last modified September 2, 2008. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uncharacterized membrane protein YFL034W
Gene names
Ordered Locus Names: YFL034W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length1073 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subunit structure

Interacts with RPP0.

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Present with 1110 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the TMCO4 family.

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Ontologies

Keywords

   Cellular componentMembrane
   DomainTransmembrane
   PTMPhosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

GDE1Q029791EBI-22823,EBI-31287
MYO1P089641EBI-22823,EBI-11650

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 10731073Uncharacterized membrane protein YFL034W

Regions

Topological domain1 – 552552Cytoplasmic Potential
Transmembrane553 – 57321 Potential
Topological domain574 – 5763Extracellular Potential
Transmembrane577 – 59721 Potential
Topological domain598 – 69497Cytoplasmic Potential
Transmembrane695 – 71521 Potential
Topological domain716 – 75237Extracellular Potential
Transmembrane753 – 77321 Potential
Topological domain774 – 1073300Cytoplasmic Potential

Amino acid modifications

Modified residue941Phosphoserine
Modified residue2111Phosphothreonine
Modified residue2151Phosphothreonine
Modified residue4351Phosphoserine
Modified residue10371Phosphoserine

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Sequences

Sequence LengthMass (Da)Tools
P43564-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C4741173778FFB05

FASTA1,073119,496
        10         20         30         40         50         60 
MSDSEEDLGV QLKGLKIARH LKESGEHTDE ESNSSPEHDC GLSNQDDLTV MHTQAKEEVF 

        70         80         90        100        110        120 
KRREEDGTRT EDALHEGEAG KEGTGFPSSQ SVCSPNEADS GIDRADKPIL LDPFKSVHDT 

       130        140        150        160        170        180 
DPVPGTKSRS NSDSDSDSDD GGWQEMPAVS SFNIYNHRGE LELTSKVRNS EQASETSPTV 

       190        200        210        220        230        240 
PPGKNCKSVN DSRFDYTKMA AEQQAQRSYR TNKKTDFLFD HKVLKKKINS SQTSVNLTSS 

       250        260        270        280        290        300 
PSTTSLNNEK NNDDDDDDSY DEYEDDVEPV NDLNRDSQLN ITKNLLSDME KFAYVGAINI 

       310        320        330        340        350        360 
LANQMCTNLA TLCLCIDIKS HKNLAHRLQF TQKDMAAWKT VVLSRLYDHL GISQEEIVMI 

       370        380        390        400        410        420 
EKLSLHKIQL EDLCKCLKTT QSIDNPWEND RDHEEDGIEE TTERMSPNEQ NGSVQASTPD 

       430        440        450        460        470        480 
PEQSATPETP KAKQSPLSSD VPGKVLDPEN VKSQDKLNID VAWTIICDLF LICLQSSTYD 

       490        500        510        520        530        540 
SRSRTLLINF AKVLNMTSLE ICEFERRVTD SLDMEQSTED QVWDEQDHMR NRRRSKRRKK 

       550        560        570        580        590        600 
MAYVALAMVG GSLVLGLSGG LLAPVIGGGI AAGLSTIGIT GATSFLTGVG GTTVVAVSST 

       610        620        630        640        650        660 
AIGANIGARG MSKRMGSVRT FEFRPLHNNR RVNLILTVSG WMVGNEDDVR LPFSTVDPVE 

       670        680        690        700        710        720 
GDLYSLYWEP EMLKSIGQTV SIVATEIFTT SLQQILGATV LTALISSIQW PMALSKLGYI 

       730        740        750        760        770        780 
LDNPWNVSLD RAWSAGKILA DTLIARNLGA RPITLVGFSI GARVIFSCLI ELCKKKALGL 

       790        800        810        820        830        840 
IENVYLFGTP AVMKKEQLVM ARSVVSGRFV NGYSDKDWFL AYLFRAAAGG FSAVMGISTI 

       850        860        870        880        890        900 
ENVEGIENIN CTEFVDGHLN YRKSMPKLLK RIGIAVLSEE FVEIEEMMNP EEVKRKRKLI 

       910        920        930        940        950        960 
NDVDAAQKKL SERKKHNSWV PKWLKPKKSK WKVMVEEAVE EGRDMQDLPE NDVNNNENEN 

       970        980        990       1000       1010       1020 
PDEHEGIARQ KRRDAALVDH GALMHELQLI KQAMHEDEIK NKACLPGEDK EVESSNDFLG 

      1030       1040       1050       1060       1070 
ESHYKPPSTP KINPPQSPNN FQLLSAGRTI LPEDDDFDPR GKKKVEFSFP DDI

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References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[3]"Identification of a hypothetical membrane protein interactor of ribosomal phosphoprotein P0."
Aruna K., Chakraborty T., Nambeesan S., Mannan A.B., Sehgal A., Balachandara S.R., Sharma S.
J. Biosci. 29:33-43(2004) [PubMed: 15286401] [Abstract]
Cited for: INTERACTION WITH RPP0.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94; THR-211; THR-215; SER-435 AND SER-1037, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

D50617 Genomic DNA. Translation: BAA09205.1.
PIRS56220.
RefSeqNP_116583.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6508N.
IntActP43564.

Proteomic databases

PeptideAtlasP43564.

Genome annotation databases

EnsemblYFL034W. Saccharomyces cerevisiae. [Contig view]
GeneID850510.
GenomeReviewsGene locus YFL034W in contig D50617_GR.
KEGGsce:YFL034W.
NMPDRfig|4932.3.peg.2245.

Organism-specific databases

CYGDYFL034w.
SGDS000001860. YFL034W.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP43564.

Gene expression databases

ArrayExpressP43564.
GermOnlineYFL034W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR007941. DUF726.
[Graphical view]
PANTHERPTHR17920. DUF726. 1 hit.
PfamPF05277. DUF726. 1 hit.
[Graphical view]
ProDomP43564.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubP43564.
ProtoNetSearch...

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Entry information

Entry nameYFD4_YEAST
AccessionPrimary (citable) accession number: P43564
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 2, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents