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Reviewed, UniProtKB/Swiss-Prot P43572 (EPL1_YEAST)

Last modified July 22, 2008. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Enhancer of polycomb-like protein 1
Gene names
Name: EPL1
Ordered Locus Names: YFL024C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length832 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.

Subunit structure

Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.

Subcellular location

Nucleus.

Miscellaneous

Present with 1110 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the enhancer of polycomb family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 832832Enhancer of polycomb-like protein 1

Regions

Compositional bias419 – 42810Poly-Ala
Compositional bias447 – 4515Poly-Gln
Compositional bias454 – 4618Poly-Gln
Compositional bias476 – 4816Poly-Ser
Compositional bias777 – 79519Poly-Gln

Amino acid modifications

Modified residue421Phosphoserine
Modified residue511Phosphoserine

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Sequences

Sequence LengthMass (Da)Tools
P43572-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: E08689465F84ABA8

FASTA83296,738
        10         20         30         40         50         60 
MPTPSNAIEI NDGSHKSGRS TRRSGSRSAH DDGLDSFSKG DSGAGASAGS SNSRFRHRKI 

        70         80         90        100        110        120 
SVKQHLKIYL PNDLKHLDKD ELQQREVVEI ETGVEKNEEK EVHLHRILQM GSGHTKHKDY 

       130        140        150        160        170        180 
IPTPDASMTW NEYDKFYTGS FQETTSYIKF SATVEDCCGT NYNMDERDET FLNEQVNKGS 

       190        200        210        220        230        240 
SDILTEDEFE ILCSSFEHAI HERQPFLSMD PESILSFEEL KPTLIKSDMA DFNLRNQLNH 

       250        260        270        280        290        300 
EINSHKTHFI TQFDPVSQMN TRPLIQLIEK FGSKIYDYWR ERKIEVNGYE IFPQLKFERP 

       310        320        330        340        350        360 
GEKEEIDPYV CFRRREVRHP RKTRRIDILN SQRLRALHQE LKNAKDLALL VAKRENVSLN 

       370        380        390        400        410        420 
WINDELKIFD QRVKIKNLKR SLNISGEDDD LINHKRKRPT IVTVEQREAE LRKAELKRAA 

       430        440        450        460        470        480 
AAAAAAKAKN NKRNNQLEDK SSRLTKQQQQ QLLQQQQQQQ QNALKTENGK QLANASSSST 

       490        500        510        520        530        540 
SQPITSHVYV KLPSSKIPDI VLEDVDALLN SKEKNARKFV QEKMEKRKIE DADVFFNLTD 

       550        560        570        580        590        600 
DPFNPVFDMS LPKNFSTSNV PFASIASSKF QIDRSFYSSH LPEYLKGISD DIRIYDSNGR 

       610        620        630        640        650        660 
SRNKDNYNLD TKRIKKTELY DPFQENLEIH SREYPIKFRK RVGRSNIKYV DRMPNFTTSS 

       670        680        690        700        710        720 
TKSACSLMDF VDFDSIEKEQ YSREGSNDTD SINVYDSKYD EFVRLYDKWK YDSPQNEYGI 

       730        740        750        760        770        780 
KFSDEPARLN QISNDTQVIR FGTMLGTKSY EQLREATIKY RRDYITRLKQ KHIQHLQQQQ 

       790        800        810        820        830 
QQQQQQQQQA QQQKQKSQNN NSNSSNSLKK LNDSLINSEA KQNSSITQKN SS

« Hide

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References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription."
Galarneau L., Nourani A., Boudreault A.A., Zhang Y., Heliot L., Allard S., Savard J., Lane W.S., Stillman D.J., Cote J.
Mol. Cell 5:927-937(2000) [PubMed: 10911987] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-16; 86-96; 101-116; 136-149; 151-178; 227-235; 275-280; 283-296; 346-367; 381-407; 471-491; 497-512; 529-569; 575-587; 594-600; 605-612; 617-632; 653-698; 711-721; 729-740; 772-794 AND 811-821, IDENTIFICATION IN THE NUA4 COMPLEX, FUNCTION.
[3]"The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals."
Stankunas K., Berger J., Ruse C., Sinclair D.A.R., Randazzo F., Brock H.W.
Development 125:4055-4066(1998) [PubMed: 9735366] [Abstract]
Cited for: GENE NAME.
[4]"Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin."
Boudreault A.A., Cronier D., Selleck W., Lacoste N., Utley R.T., Allard S., Savard J., Lane W.S., Tan S., Cote J.
Genes Dev. 17:1415-1428(2003) [PubMed: 12782659] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE NUA4 COMPLEX, MASS SPECTROMETRY.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Barrier proteins remodel and modify chromatin to restrict silenced domains."
Oki M., Valenzuela L., Chiba T., Ito T., Kamakaka R.T.
Mol. Cell. Biol. 24:1956-1967(2004) [PubMed: 14966276] [Abstract]
Cited for: FUNCTION.
[8]"The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres."
Zhang H., Richardson D.O., Roberts D.N., Utley R.T., Erdjument-Bromage H., Tempst P., Cote J., Cairns B.R.
Mol. Cell. Biol. 24:9424-9436(2004) [PubMed: 15485911] [Abstract]
Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, MASS SPECTROMETRY.
[9]"A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin."
Kobor M.S., Venkatasubrahmanyam S., Meneghini M.D., Gin J.W., Jennings J.L., Link A.J., Madhani H.D., Rine J.
PLoS Biol. 2:587-599(2004) [PubMed: 15045029] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE NUA4 COMPLEX, MASS SPECTROMETRY.
[10]"Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4."
Krogan N.J., Baetz K., Keogh M.-C., Datta N., Sawa C., Kwok T.C.Y., Thompson N.J., Davey M.G., Pootoolal J., Hughes T.R., Emili A., Buratowski S., Hieter P., Greenblatt J.F.
Proc. Natl. Acad. Sci. U.S.A. 101:13513-13518(2004) [PubMed: 15353583] [Abstract]
Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, MASS SPECTROMETRY.
[11]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-51, MASS SPECTROMETRY.

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Cross-references

Sequence databases

D50617 Genomic DNA. Translation: BAA09214.1.
PIRS56230.
RefSeqNP_116629.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5904N.
IntActP43572.

Proteomic databases

PeptideAtlasP43572.

Genome annotation databases

EnsemblYFL024C. Saccharomyces cerevisiae. [Contig view]
GeneID850520.
GenomeReviewsGene locus YFL024C in contig D50617_GR.
KEGGsce:YFL024C.
NMPDRfig|4932.3.peg.2256.

Organism-specific databases

CYGDYFL024c.
SGDS000001870. EPL1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP43572.

Gene expression databases

ArrayExpressP43572.
GermOnlineYFL024C. Saccharomyces cerevisiae.

Family and domain databases

ProDomP43572.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubP43572.
ProtoNetSearch...

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Entry information

Entry nameEPL1_YEAST
AccessionPrimary (citable) accession number: P43572
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 22, 2008
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents