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Reviewed, UniProtKB/Swiss-Prot P43579 (IES1_YEAST)

Last modified September 2, 2008. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ino eighty subunit 1
Gene names
Name: IES1
Ordered Locus Names: YFL013C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length692 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex.

Subunit structure

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.

Subcellular location

Nucleus.

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing

Gene Ontology (GO)

   Biological processchromatin remodeling Ref.2

Inferred from physical interaction. Source: SGD

   Cellular componentINO80 complex Ref.2

Inferred from physical interaction. Source: SGD

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 692692Ino eighty subunit 1

Regions

Coiled coil340 – 38546 Potential

Amino acid modifications

Modified residue271Phosphoserine
Modified residue341Phosphoserine
Modified residue361Phosphoserine
Modified residue471Phosphoserine
Modified residue4431Phosphoserine
Modified residue4461Phosphothreonine
Modified residue4931Phosphoserine
Modified residue5041Phosphoserine
Modified residue5071Phosphothreonine
Modified residue5161Phosphothreonine
Modified residue5671Phosphothreonine
Modified residue5741Phosphoserine

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Sequences

Sequence LengthMass (Da)Tools
P43579-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9C0084A36431B241

FASTA69278,753
        10         20         30         40         50         60 
MGKRVYDPIH DTFQLREDNS DETKADSPMQ SVKSGSQEEA SPSSIQSETE TVTTKSIPVI 

        70         80         90        100        110        120 
HEIEIDDKND DDSTQSEEEN TNILLNFEPS TVPEATGAST ATGPVTTNTV RRKPKESNAS 

       130        140        150        160        170        180 
KYNRHLKKPD GEPFNRKDIQ FSFMQELLMD KRQIFTNVLK PLYKNSIVPI NIDGDKLSIN 

       190        200        210        220        230        240 
VTDKEYDART FVFNDKLTFA QLYVLTIATS IKCSKILRDK LLLDQQVAFS TCVLALLVNI 

       250        260        270        280        290        300 
GRLNTTINFY LEMTSQLRTF HSVPVLQLHA NDPKLLQDTP RLKSILKNLP WGNEQLSLME 

       310        320        330        340        350        360 
TYKKVDQNDG EVDTVNKFNI INMLFSICDN SGLIDKRFLS KYVEVESKAQ EQDMVDEQNE 

       370        380        390        400        410        420 
VKETEAENEK QESKAAYATT LFDILDYSKY EPKDRSNILI WLLYIHLETN LSQEEVEESV 

       430        440        450        460        470        480 
RFFNGLEDGA PAGKFILRCT ERSYDTDPED ELEFGANQRI KRREFMSKME EGRKRERTNV 

       490        500        510        520        530        540 
TEVKKPSIGG DKSEEDGEGE DDKSEETVEE TRSLLTPTPI LESSSPMTLN RKKVTPQLPK 

       550        560        570        580        590        600 
VTPAAPTETE EEITSAAIID KNDLNLTPLK KYNSSATVNK VDKLISLDLN KHVSENGKTQ 

       610        620        630        640        650        660 
EEFLADLKKS QVPNRLKRRD IGLIKIFNEF EDIPVASVLG IRGKKRKKFK DNLLGFETDF 

       670        680        690 
MKNLGASKKV LLNKIERAEI DDEEATAMFK LE

« Hide

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References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
Shen X., Ranallo R., Choi E., Wu C.
Mol. Cell 12:147-155(2003) [PubMed: 12887900] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION IN THE INO80 COMPLEX.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; SER-493; SER-504 AND THR-507, MASS SPECTROMETRY.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-36; SER-47; SER-443; THR-446; THR-516; THR-567 AND SER-574, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

D50617 Genomic DNA. Translation: BAA09225.1.
Z46255 Genomic DNA. Translation: CAA86347.1.
PIRS48316.
RefSeqNP_116641.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:3869N.
IntActP43579.

Genome annotation databases

EnsemblYFL013C. Saccharomyces cerevisiae. [Contig view]
GeneID850534.
GenomeReviewsGene locus YFL013C in contig D50617_GR.
KEGGsce:YFL013C.
NMPDRfig|4932.3.peg.2271.

Organism-specific databases

CYGDYFL013c.
SGDS000001881. IES1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP43579.

Gene expression databases

ArrayExpressP43579.
GermOnlineYFL013C. Saccharomyces cerevisiae.

Family and domain databases

ProDomP43579.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubP43579.
ProtoNetSearch...

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Entry information

Entry nameIES1_YEAST
AccessionPrimary (citable) accession number: P43579
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 2, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents