Reviewed, UniProtKB/Swiss-Prot P44488 (UXUA_HAEIN)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	HI0055

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O.
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion.
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Mannonate dehydratase		PRO_0000170675

Sequences

	Sequence		Length	Mass (Da)
	P44488-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: CFE4DCE635AAAB0C	FASTA	394	45,205
	10 20 30 40 50 60 MEQAWRWYGP KDPVSLSDIR QAGATGIVTA LHHIPNGEIW GIEEIKKRKT EIENAGLSWS 70 80 90 100 110 120 VVESVPVHEE IKTQTGNYQK WINNYKQTLR NLAQCGIDTV CYNFMPVLDW TRTDLAYELP 130 140 150 160 170 180 DGSKALRFDH IAFAAFELHI LKRPDAEKTY NQEEQVAART YYDNMSEQDI AQLTRNIIAG 190 200 210 220 230 240 LPGAEEGYTL DEFQTQLDRY KDISSEKFRT HLAYFLNEIV PVAQEIGIKM AIHPDDPPRP 250 260 270 280 290 300 ILGLPRIVST IEDMQWFVET QPLPANGFTM CTGSYGVRSD NDLVKMTEQF ADRIYFAHLR 310 320 330 340 350 360 STQREGNPLT FHEAAHLEGD VDMFNVVKAL LNEEYRRLNQ GETRLIPMRP DHGHQILDDL 370 380 390 RKKTNPGYSA IGRLKGLAEF RGLEMALKKV YFNK

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21733.1.
PIR	E64045.
RefSeq	NP_438228.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950950.
GenomeReviews	Gene locus HI0055 in contig L42023_GR.
KEGG	hin:HI0055.
NMPDR	fig|71421.1.peg.54.
TIGR	HI0055.
Phylogenomic databases
HOGENOM	P44488.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0055-MON.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_HAEIN

Accession

Primary (citable) accession number: P44488

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)