Reviewed, UniProtKB/Swiss-Prot P47741 (TNR4_MOUSE)

Names and origin

Protein names

Recommended name:
    Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
    OX40L receptor
    OX40 antigen
    CD_antigen=CD134

Gene names

Name:	Tnfrsf4
Synonyms:	Ox40, Txgp1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for TNFSF4/OX40L/GP34.
Subunit structure	Interacts with TRAF2, TRAF3 and TRAF5 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cellular defense response Inferred from mutant phenotype. Source: MGI inflammatory response Inferred from mutant phenotype. Source: MGI negative regulation of cytokine secretion Inferred from physical interaction. Source: MGI regulation of apoptosis Inferred from mutant phenotype. Source: MGI regulation of protein kinase activity Inferred from mutant phenotype. Source: MGI
Cellular component	external side of plasma membrane Inferred from direct assay. Source: MGI
Molecular function	tumor necrosis factor receptor activity Inferred from physical interaction. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRAF2	Q12933	1	EBI-520001,EBI-355744	From a different organism.
Traf2	P39429	2	EBI-520001,EBI-520016
Traf3	Q60803	2	EBI-520001,EBI-520135

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 272	253	Tumor necrosis factor receptor superfamily member 4
Regions
	Topological domain	20 – 211	192	Extracellular Potential
	Transmembrane	212 – 236	25	Potential
	Topological domain	237 – 272	36	Cytoplasmic Potential
	Repeat	26 – 61	36	TNFR-Cys 1
	Repeat	62 – 103	42	TNFR-Cys 2
	Repeat	104 – 124	21	TNFR-Cys 3; truncated
	Repeat	125 – 165	41	TNFR-Cys 4
Amino acid modifications
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Disulfide bond	27 ↔ 38		By similarity
	Disulfide bond	39 ↔ 52		By similarity
	Disulfide bond	42 ↔ 60		By similarity
	Disulfide bond	63 ↔ 77		By similarity
	Disulfide bond	80 ↔ 95		By similarity
	Disulfide bond	83 ↔ 103		By similarity
	Disulfide bond	105 ↔ 123		By similarity
	Disulfide bond	126 ↔ 139		By similarity
	Disulfide bond	145 ↔ 164		By similarity
Experimental info
	Sequence conflict	15	1	A → G in CAA59476. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P47741-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 06E7BB4156F0D08E	FASTA	272	30,154
	10 20 30 40 50 60 MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS RCDHTRDTLC 70 80 90 100 110 120 HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD TVCRCRPGTQ PRQDSGYKLG 130 140 150 160 170 180 VDCVPCPPGH FSPGNNQACK PWTNCTLSGK QTRHPASDSL DAVCEDRSLL ATLLWETQRP 190 200 210 220 230 240 TFRPTTVQST TVWPRTSELP SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW 250 260 270 RLPNTPKPCW GNSFRTPIQE EHTDAHFTLA KI

References

[1]	"Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions." Calderhead D.M., Buhlmann J.E., van den Eertwegh A.J., Claassen E., Noelle R.J., Fell H. J. Immunol. 151:5261-5271(1993) [PubMed: 8228223] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein." Birkeland M.L., Copeland N.G., Gilbert D.J., Jenkins N.A., Barclay A.N. Eur. J. Immunol. 25:926-930(1995) [PubMed: 7737295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z21674 mRNA. Translation: CAA79772.1. X85214 Genomic DNA. Translation: CAA59476.1.
PIR	I48700.
UniGene	Mm.13885
3D structure databases
HSSP	HSSP built from PDB template 1JMA based on UniProtKB Q92956.
SMR	P47741. Positions 25-166.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:6239N.
IntAct	P47741.
Genome annotation databases
Ensembl	ENSMUSG00000029075. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:104512. Tnfrsf4.
Phylogenomic databases
HOGENOM	P47741.
HOVERGEN	P47741.
Gene expression databases
ArrayExpress	P47741.
GermOnline	ENSMUSG00000029075. Mus musculus.
Family and domain databases
InterPro	IPR001368. TNFR_c6. [Graphical view]
Pfam	PF00020. TNFR_c6. 2 hits. [Graphical view]
SMART	SM00208. TNFR. 3 hits. [Graphical view]
PROSITE	PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 2 hits. [Graphical view]
ProDom	P47741. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

TNR4_MOUSE

Accession

Primary (citable) accession number: P47741

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	July 22, 2008
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)