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Reviewed, UniProtKB/Swiss-Prot P47745 (AA1R_CAVPO)

Last modified September 2, 2008. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine receptor A1
Gene names
Name: ADORA1
OrganismCavia porcellus (Guinea pig)
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

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Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 326326Adenosine receptor A1

Regions

Topological domain1 – 1010Extracellular Potential
Transmembrane11 – 33231 Potential
Topological domain34 – 4613Cytoplasmic Potential
Transmembrane47 – 69232 Potential
Topological domain70 – 8011Extracellular Potential
Transmembrane81 – 102223 Potential
Topological domain103 – 12321Cytoplasmic Potential
Transmembrane124 – 146234 Potential
Topological domain147 – 17630Extracellular Potential
Transmembrane177 – 201255 Potential
Topological domain202 – 23534Cytoplasmic Potential
Transmembrane236 – 259246 Potential
Topological domain260 – 2678Extracellular Potential
Transmembrane268 – 292257 Potential
Topological domain293 – 32634Cytoplasmic Potential

Amino acid modifications

Lipidation3091S-palmitoyl cysteine Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Disulfide bond80 ↔ 169 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P47745-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: A2E8D594F5D6A233

FASTA32636,493
        10         20         30         40         50         60 
MPHSVSAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIAS LAVADVAVGA 

        70         80         90        100        110        120 
LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKTVVT 

       130        140        150        160        170        180 
PRRAAVAIAG CWILSLVVGL TPMFGWNNLS KIEMAWAANG SVGEPVIKCE FEKVISMEYM 

       190        200        210        220        230        240 
VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LSKKVSASSG DPQKYYGKEL KIAKSLALIL 

       250        260        270        280        290        300 
FLFALSWLPL HILNCITLFC PTCHKPTILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 

       310        320 
KIWNDHFRCQ PEPPIDEDLP EEKVDD

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References

[1]"Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain."
Meng F., Xie G.X., Chalmers D., Morgan C., Watson S.J. Jr., Akil H.
Brain Res. Mol. Brain Res. 26:143-155(1994) [PubMed: 7854041] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.
Tissue: Brain.

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Cross-references

Sequence databases

U04279 mRNA. Translation: AAB60505.1.
PIRI48096.

3D structure databases

HSSPHSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:440N.

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSCPOG00000005213. Cavia porcellus. [Contig view]

Phylogenomic databases

HOVERGENP47745.

Family and domain databases

InterProIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PANTHERPTHR19266:SF15. Adeno_A1_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomP47745.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameAA1R_CAVPO
AccessionPrimary (citable) accession number: P47745
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 2, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents