Aldehyde dehydrogenase family 1 member A3

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Reviewed, UniProtKB/Swiss-Prot P47895 (AL1A3_HUMAN)

Last modified July 22, 2008. Version 73. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase family 1 member A3
    EC=1.2.1.5
Alternative name(s):
    Aldehyde dehydrogenase 6
    Retinaldehyde dehydrogenase 3
      Short name(s)=RALDH-3

Gene names

Name:	ALDH1A3
Synonyms:	ALDH6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system By similarity.
Catalytic activity	An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.
Pathway	Cofactor metabolism; retinol metabolism.
Subcellular location	CytoplasmBy similarity.
Tissue specificity	Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

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Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	alcohol metabolic process Ref.1 Traceable author statement. Source: ProtInc lipid metabolic process Ref.1 Traceable author statement. Source: ProtInc
Molecular function	3-chloroallyl aldehyde dehydrogenase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

1 – 512

512

Aldehyde dehydrogenase family 1 member A3

Regions

Nucleotide binding

257 – 262

NAD By similarity

Sites

Active site

280

Proton acceptor By similarity

Active site

314

Nucleophile By similarity

Site

181

Transition state stabilizer By similarity

Natural variations

Natural variant

386

M → V: dbSNP rs3803430.

Experimental info

Sequence conflict

R → G in AAA79036. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P47895-1 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 1BFCF4F56F0FE89A
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FASTA

512

56,108

        10         20         30         40         50         60 
MATANGAVEN GQPDRKPPAL PRPIRNLEVK FTKIFINNEW HESKSGKKFA TCNPSTREQI 

        70         80         90        100        110        120 
CEVEEGDKPD VDKAVEAAQV AFQRGSPWRR LDALSRGRLL HQLADLVERD RATLAALETM 

       130        140        150        160        170        180 
DTGKPFLHAF FIDLEGCIRT LRYFAGWADK IQGKTIPTDD NVVCFTRHEP IGVCGAITPW 

       190        200        210        220        230        240 
NFPLLMLVWK LAPALCCGNT MVLKPAEQTP LTALYLGSLI KEAGFPPGVV NIVPGFGPTV 

       250        260        270        280        290        300 
GAAISSHPQI NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGKNPCIVC ADADLDLAVE 

       310        320        330        340        350        360 
CAHQGVFFNQ GQCCTAASRV FVEEQVYSEF VRRSVEYAKK RPVGDPFDVK TEQGPQIDQK 

       370        380        390        400        410        420 
QFDKILELIE SGKKEGAKLE CGGSAMEDKG LFIKPTVFSE VTDNMRIAKE EIFGPVQPIL 

       430        440        450        460        470        480 
KFKSIEEVIK RANSTDYGLT AAVFTKNLDK ALKLASALES GTVWINCYNA LYAQAPFGGF 

       490        500        510 
KMSGNGRELG EYALAEYTEV KTVTIKLGDK NP

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6." Hsu L.C., Chang W.-C., Hiraoka L., Hsieh C.-L. Genomics 24:333-341(1994) [PubMed: 7698756] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Salivary gland.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.

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Cross-references

Sequence databases
	U07919 mRNA. Translation: AAA79036.1. BC069274 mRNA. Translation: AAH69274.1.
PIR	A55684.
RefSeq	NP_000684.2.
UniGene	Hs.459538
3D structure databases
HSSP	HSSP built from PDB template 1BI9 based on UniProtKB Q63639.
ModBase	Search...
Proteomic databases
PeptideAtlas	P47895.
Genome annotation databases
Ensembl	ENSG00000184254. Homo sapiens. [Contig view]
GeneID	220.
KEGG	hsa:220.
NMPDR	fig\|9606.3.peg.11311.
Organism-specific databases
H-InvDB	HIX0026851.
HGNC	HGNC:409. ALDH1A3.
MIM	600463. gene.
PharmGKB	PA24694.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	P47895.
HOVERGEN	P47895.
Gene expression databases
ArrayExpress	P47895.
CleanEx	HS_ALDH1A3.
GermOnline	ENSG00000184254. Homo sapiens.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProDom	P47895. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
DrugBank	DB00157. NADH. DB00162. Vitamin A.
SOURCE	Search...
ProtoNet	Search...

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Entry information

Entry name

AL1A3_HUMAN

Accession

Primary (citable) accession number: P47895
Secondary accession number(s): Q6NT64

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	September 27, 2004
Last modified:	July 22, 2008
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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