Reviewed, UniProtKB/Swiss-Prot P47945 (MT4_MOUSE)

Names and origin

Protein names

Recommended name:
    Metallothionein-4
      Short name=MT-4
Alternative name(s):
    Metallothionein-IV
      Short name=MT-IV

Gene names

Name:

Mt4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	62 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
Tissue specificity	Expressed exclusively in stratified squamous epithelia associated with oral epithelia, esophagus, upper stomach, tail, footpads and neonatal skin.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Copper Metal-binding Metal-thiolate cluster Zinc
Gene Ontology (GO)
Biological process	cellular metal ion homeostasis Inferred from direct assay. Source: MGI
Molecular function	metal ion binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 62	62	Metallothionein-4
Sites
	Metal binding	6	1	Cluster B By similarity
	Metal binding	8	1	Cluster B By similarity
	Metal binding	14	1	Cluster B By similarity
	Metal binding	16	1	Cluster B By similarity
	Metal binding	20	1	Cluster B By similarity
	Metal binding	22	1	Cluster B By similarity
	Metal binding	25	1	Cluster B By similarity
	Metal binding	27	1	Cluster B By similarity
	Metal binding	30	1	Cluster B By similarity
	Metal binding	34	1	Cluster A By similarity
	Metal binding	35	1	Cluster A By similarity
	Metal binding	37	1	Cluster A By similarity
	Metal binding	38	1	Cluster A By similarity
	Metal binding	42	1	Cluster A By similarity
	Metal binding	45	1	Cluster A By similarity
	Metal binding	49	1	Cluster A By similarity
	Metal binding	51	1	Cluster A By similarity
	Metal binding	58	1	Cluster A By similarity
	Metal binding	60	1	Cluster A By similarity
	Metal binding	61	1	Cluster A By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47945-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 8F78DA6D0744333A	FASTA	62	6,277
	10 20 30 40 50 60 MDPGECTCMS GGICICGDNC KCTTCSCKTC RKSCCPCCPP GCAKCARGCI CKGGSDKCSC CP

References

[1]	"Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia." Quaife C.J., Findley S.D., Erickson J.C., Froelick G.J., Kelly E.J., Zambrowicz B.P., Palmiter R.D. Biochemistry 33:7250-7259(1994) [PubMed: 8003488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U07808 Genomic DNA. Translation: AAA20233.1.
PIR	B53640.
RefSeq	NP_032657.1.
UniGene	Mm.1536
3D structure databases
HSSP	HSSP built from PDB template 1MRB based on UniProtKB P18055.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000031757. Mus musculus. [Contig view]
GeneID	17752.
KEGG	mmu:17752.
Organism-specific databases
MGI	MGI:99692. Mt4.
Phylogenomic databases
HOGENOM	P47945.
HOVERGEN	P47945.
Gene expression databases
ArrayExpress	P47945.
CleanEx	MM_MT4.
GermOnline	ENSMUSG00000031757. Mus musculus.
Family and domain databases
InterPro	IPR001450. 4Fe4S_Fe_S_bd. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00353. 4FE4SFRDOXIN. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P47945. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

MT4_MOUSE

Accession

Primary (citable) accession number: P47945

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	July 22, 2008
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)