Reviewed, UniProtKB/Swiss-Prot P48933 (DHSB_CYACA)

Names and origin

Protein names

Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit
    EC=1.3.5.1
Alternative name(s):
    Iron-sulfur subunit of complex II
      Short name=Ip

Gene names

Name:	SDH2
Synonyms:	SDHB

Encoded on

Mitochondrion

Organism

Cyanidium caldarium

Taxonomic identifier

2771 [NCBI]

Taxonomic lineage

Eukaryota › Rhodophyta › Bangiophyceae › Cyanidiales › Cyanidiaceae › Cyanidium

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.
Catalytic activity	Succinate + ubiquinone = fumarate + ubiquinol.
Cofactor	Binds 1 2Fe-2S cluster By similarity. Binds 1 3Fe-4S cluster By similarity. Binds 1 4Fe-4S cluster By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix sideBy similarity.
Sequence similarities	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	2Fe-2S 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 262	262	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit
Regions
	Domain	21 – 110	90	2Fe-2S ferredoxin-type
	Domain	154 – 184	31	4Fe-4S ferredoxin-type
Sites
	Metal binding	73	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	78	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	81	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	93	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	164	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	167	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	170	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	174	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	221	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	227	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	231	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Binding site	179	1	Ubiquinone; shared with DHSD By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48933-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: D068EBCDB33B5580	FASTA	262	30,268
	10 20 30 40 50 60 MNLFSLKAEK FLNLKTLSDL KLIKIFRWDS SEKKDPWYST YVVSLKNCGP IVLDALIKIK 70 80 90 100 110 120 NECDSTVSFR RSCREGICGS CAININGTNS LACLQKLNIK NNIIYVYPLP HIFVLKDLVV 130 140 150 160 170 180 DLTNFYAQYR LIQPWLQSSL NIKSKKEIYQ SKQDRLYLDG LYECILCACC SASCPSYWWN 190 200 210 220 230 240 HDKYLGPAVL LQAYRWIVDS RDDNTLSRLL SLKDSYKLYR CHTIMNCTKT CPKHLNPGKV 250 260 IASIKKRLLN LEVLGEKRDL NS

References

[1]	"Genes for two subunits of succinate dehydrogenase form a cluster on the mitochondrial genome of Rhodophyta." Viehmann S., Richard O., Boyen C., Zetsche K. Curr. Genet. 29:199-201(1996) [PubMed: 8821668] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RK-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z48930 Genomic DNA. Translation: CAA88766.1.
PIR	S62756.
3D structure databases
HSSP	HSSP built from PDB template 1NEK based on UniProtKB P07014.
ModBase	Search...
Family and domain databases
InterPro	IPR006058. 2Fe2S_fd_BS. IPR001450. 4Fe4S_Fe_S_bd. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. IPR012285. Fum_reductase_C. IPR004489. Succ_DHase/fum_Rdtase_Fe-S. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
TIGRFAMs	TIGR00384. dhsB. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProDom	P48933. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

DHSB_CYACA

Accession

Primary (citable) accession number: P48933

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	September 2, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)