Reviewed, UniProtKB/Swiss-Prot P49650 (P2RY1_MOUSE)

Names and origin

Protein names

Recommended name:
    P2Y purinoceptor 1
      Short name=P2Y1
Alternative name(s):
    Purinergic receptor
    ATP receptor

Gene names

Name:

P2ry1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for extracellular adenine nucleotides such as ATP and ADP. In pancreatic islets, may mediate some of the effects of extracellular ATP on insulin secretion.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	positive regulation of ion transport Inferred from genetic interaction. Source: MGI
Cellular component	plasma membrane Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 373	373	P2Y purinoceptor 1
Regions
	Topological domain	1 – 52	52	Extracellular Potential
	Transmembrane	53 – 74	22	1 Potential
	Topological domain	75 – 87	13	Cytoplasmic Potential
	Transmembrane	88 – 109	22	2 Potential
	Topological domain	110 – 126	17	Extracellular Potential
	Transmembrane	127 – 147	21	3 Potential
	Topological domain	148 – 166	19	Cytoplasmic Potential
	Transmembrane	167 – 188	22	4 Potential
	Topological domain	189 – 218	30	Extracellular Potential
	Transmembrane	219 – 238	20	5 Potential
	Topological domain	239 – 265	27	Cytoplasmic Potential
	Transmembrane	266 – 285	20	6 Potential
	Topological domain	286 – 303	18	Extracellular Potential
	Transmembrane	304 – 328	25	7 Potential
	Topological domain	329 – 373	45	Cytoplasmic Potential
Amino acid modifications
	Modified residue	352	1	Phosphoserine By similarity
	Modified residue	354	1	Phosphoserine By similarity
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
	Glycosylation	27	1	N-linked (GlcNAc...) Potential
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	197	1	N-linked (GlcNAc...) Potential
	Disulfide bond	124 ↔ 202		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49650-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 944125E9F4560BB3	FASTA	373	42,213
	10 20 30 40 50 60 MTEVPWSVVP NGTDAAFLAG LGSLWGNSTV ASTAAVSSSF QCALTKTGFQ FYYLPAVYIL 70 80 90 100 110 120 VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY VLTLPALIFY YFNKTDWIFG 130 140 150 160 170 180 DAMCKLQRFI FHVNLYGSIL FLTCISAHRY SGVVYPLKSL GRLKKKNAIY VSVLVWLIVV 190 200 210 220 230 240 VAISPILFYS GTGTRKNKTV TCYDTTSNDY LRSYFIYSMC TTVAMFCIPL VLILGCYGLI 250 260 270 280 290 300 VKALIYNDLD NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPEMCDFND 310 320 330 340 350 360 RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL QSKSEEMTLN 370 ILSEFKQNGD TSL

References

[1]	"Cloning of rat and mouse P2Y purinoceptors." Tokuyama Y., Hara M., Jones E.M.C., Fan Z., Bell G.I. Biochem. Biophys. Res. Commun. 211:211-218(1995) [PubMed: 7779087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Insulinoma.
[2]	"Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice." Leon C., Hechler B., Freund M., Eckly A., Vial C., Ohlmann P., Dierich A., LeMeur M., Cazenave J.-P., Gachet C. J. Clin. Invest. 104:1731-1737(1999) [PubMed: 10606627] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U22829 mRNA. Translation: AAA91302.1. AJ245636 Genomic DNA. Translation: CAB57317.1.
RefSeq	NP_032798.1.
UniGene	Mm.281452
3D structure databases
HSSP	HSSP built from PDB template 1DDD based on UniProtKB P34996.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P49650.
Genome annotation databases
Ensembl	ENSMUSG00000027765. Mus musculus. [Contig view]
GeneID	18441.
KEGG	mmu:18441.
Organism-specific databases
MGI	MGI:105049. P2ry1.
Phylogenomic databases
HOGENOM	P49650.
HOVERGEN	P49650.
Gene expression databases
ArrayExpress	P49650.
CleanEx	MM_P2RY1.
GermOnline	ENSMUSG00000027765. Mus musculus.
Family and domain databases
InterPro	IPR001277. CXC_4_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002286. P2_purnocptor. IPR000142. P2Y_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00645. CXCCHMKINER4. PR00237. GPCRRHODOPSN. PR00595. P2Y1PRNOCPTR. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	P49650. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

P2RY1_MOUSE

Accession

Primary (citable) accession number: P49650

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	July 22, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)