Reviewed, UniProtKB/Swiss-Prot P49652 (P2RY1_MELGA)

Names and origin

Protein names

Recommended name:
    P2Y purinoceptor 1
      Short name(s)=P2Y1
Alternative name(s):
    Purinergic receptor
    ATP receptor
    6H1 orphan receptor

Gene names

Name:

P2RY1

Organism

Meleagris gallopavo (Common turkey)

Taxonomic identifier

9103 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Meleagridinae › Meleagris

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for extracellular adenine nucleotides such as ATP and ADP. Seems to mediate its action via a pertussis toxin insensitive G-protein, probably belonging to the Gq family that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Mainly found in blood, brain, and lung. To a lesser extent in stomach, gut and skeletal muscle.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 362	362	P2Y purinoceptor 1
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 63	22	1 Potential
	Topological domain	64 – 76	13	Cytoplasmic Potential
	Transmembrane	77 – 98	22	2 Potential
	Topological domain	99 – 115	17	Extracellular Potential
	Transmembrane	116 – 136	21	3 Potential
	Topological domain	137 – 155	19	Cytoplasmic Potential
	Transmembrane	156 – 177	22	4 Potential
	Topological domain	178 – 207	30	Extracellular Potential
	Transmembrane	208 – 227	20	5 Potential
	Topological domain	228 – 254	27	Cytoplasmic Potential
	Transmembrane	255 – 274	20	6 Potential
	Topological domain	275 – 292	18	Extracellular Potential
	Transmembrane	293 – 317	25	7 Potential
	Topological domain	318 – 362	45	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
	Glycosylation	26	1	N-linked (GlcNAc...) Potential
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Disulfide bond	113 ↔ 191		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49652-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 3E128AB9EB64349C	FASTA	362	41,180
	10 20 30 40 50 60 MTEALISAAL NGTQPELLAG GWAAGNASTK CSLTKTGFQF YYLPTVYILV FITGFLGNSV 70 80 90 100 110 120 AIWMFVFHMR PWSGISVYMF NLALADFLYV LTLPALIFYY FNKTDWIFGD VMCKLQRFIF 130 140 150 160 170 180 HVNLYGSILF LTCISVHRYT GVVHPLKSLG RLKKKNAVYV SSLVWALVVA VIAPILFYSG 190 200 210 220 230 240 TGVRRNKTIT CYDTTADEYL RSYFVYSMCT TVFMFCIPFI VILGCYGLIV KALIYKDLDN 250 260 270 280 290 300 SPLRRKSIYL VIIVLTVFAV SYLPFHVMKT LNLRARLDFQ TPQMCAFNDK VYATYQVTRG 310 320 330 340 350 360 LASLNSCVDP ILYFLAGDTF RRRLSRATRK SSRRSEPNVQ SKSEEMTLNI LTEYKQNGDT SL

References

[1]	"Expression of a cloned P2Y purinergic receptor that couples to phospholipase C." Filtz T.M., Li Q., Boyer J.L., Nicholas R.A., Harden T.K. Mol. Pharmacol. 46:8-14(1994) [PubMed: 8058061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses." Li Q., Schachter J.B., Harden T.K., Nicholas R.A. Biochem. Biophys. Res. Commun. 236:455-460(1997) [PubMed: 9240460] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U09842 mRNA. Translation: AAA18784.1. AF012103 mRNA. Translation: AAB65428.1.
3D structure databases
HSSP	HSSP built from PDB template 1DDD based on UniProtKB P34996.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Phylogenomic databases
HOVERGEN	P49652.
Family and domain databases
InterPro	IPR001277. CXC_4_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002286. P2_purnocptor. IPR000142. P2Y_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00645. CXCCHMKINER4. PR00237. GPCRRHODOPSN. PR00595. P2Y1PRNOCPTR. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	P49652. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

P2RY1_MELGA

Accession

Primary (citable) accession number: P49652

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	July 22, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)