Reviewed, UniProtKB/Swiss-Prot P50052 (AGTR2_HUMAN)

Names and origin

Protein names

Recommended name:
    Type-2 angiotensin II receptor
Alternative name(s):
    AT2

Gene names

Name:

AGTR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
Subunit structure	Interacts with MTUS1.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	G-protein signaling, coupled to cGMP nucleotide second messenger Inferred from sequence or structural similarity. Source: UniProtKB behavior Inferred from mutant phenotype. Source: UniProtKB blood vessel remodeling Traceable author statement. Source: UniProtKB brain development Non-traceable author statement. Source: UniProtKB negative regulation of blood vessel endothelial cell migration Non-traceable author statement. Source: UniProtKB negative regulation of cell growth Traceable author statement. Source: UniProtKB negative regulation of heart rate Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of nerve growth factor receptor signaling pathway Inferred from mutant phenotype. Source: UniProtKB nitric oxide mediated signal transduction Traceable author statement. Source: UniProtKB positive regulation of apoptosis Inferred from mutant phenotype. Source: UniProtKB positive regulation of nitric oxide biosynthetic process Inferred by curator. Source: UniProtKB positive regulation of nitric-oxide synthase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of phosphoprotein phosphatase activity Inferred from direct assay. Source: UniProtKB positive regulation of vasodilation Inferred from direct assay. Source: UniProtKB protein kinase cascade Inferred from sequence or structural similarity. Source: UniProtKB regulation of systemic arterial blood pressure by circulatory renin-angiotensin Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	integral to plasma membrane Ref.3 Traceable author statement. Source: ProtInc
Molecular function	angiotensin type II receptor activity Traceable author statement. Source: ProtInc receptor antagonist activity Traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TIMP3	P35625	5	EBI-1748067,EBI-1748085

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 363	363	Type-2 angiotensin II receptor
Regions
	Topological domain	1 – 45	45	Extracellular Potential
	Transmembrane	46 – 71	26	1 Potential
	Topological domain	72 – 80	9	Cytoplasmic Potential
	Transmembrane	81 – 102	22	2 Potential
	Topological domain	103 – 119	17	Extracellular Potential
	Transmembrane	120 – 140	21	3 Potential
	Topological domain	141 – 160	20	Cytoplasmic Potential
	Transmembrane	161 – 179	19	4 Potential
	Topological domain	180 – 208	29	Extracellular Potential
	Transmembrane	209 – 234	26	5 Potential
	Topological domain	235 – 256	22	Cytoplasmic Potential
	Transmembrane	257 – 278	22	6 Potential
	Topological domain	279 – 297	19	Extracellular Potential
	Transmembrane	298 – 318	21	7 Potential
	Topological domain	319 – 363	45	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Glycosylation	24	1	N-linked (GlcNAc...) Potential
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 290		By similarity
	Disulfide bond	117 ↔ 195		By similarity
Natural variations
	Natural variant	248	1	R → K: dbSNP rs5191.
	Natural variant	268	1	C → W: dbSNP rs1042860.
Experimental info
	Sequence conflict	269	1	W → C Ref.5
	Sequence conflict	272	1	F → L in AAA50762. Ref.4
	Sequence conflict	323	1	N → G in AAA50762. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P50052-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: FDD7D4E6F9B43E60	FASTA	363	41,184
	10 20 30 40 50 60 MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL YYIIFVIGFL 70 80 90 100 110 120 VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF 130 140 150 160 170 180 GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY 190 200 210 220 230 240 FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK 250 260 270 280 290 300 TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL 310 320 330 340 350 360 PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR KSSSLREMET FVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence and genomic organization of the human type 2 angiotensin II receptor." Martin M.M., Elton T.S. Biochem. Biophys. Res. Commun. 209:554-562(1995) [PubMed: 7733925] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization." Chassagne C., Beatty B.G., Meloche S. Genomics 25:601-603(1995) [PubMed: 7790004] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[3]	"Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung." Koike G., Horiuchi M., Yamada T., Szpirer C., Jacob H.J., Dzau V.J. Biochem. Biophys. Res. Commun. 203:1842-1850(1994) [PubMed: 7945336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[4]	"Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor." Tsuzuki S., Ichiki T., Nakakubo H., Kitami Y., Guo D.F., Shirai H., Inagami T. Biochem. Biophys. Res. Commun. 200:1449-1454(1994) [PubMed: 8185599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[5]	"Molecular cloning of the human angiotensin II type 2 receptor cDNA." Martin M.M., Su B., Elton T.S. Biochem. Biophys. Res. Commun. 205:645-651(1994) [PubMed: 7999093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[6]	"Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues." Lazard D., Briend-Sutren M.M., Villageois P., Mattei M.-G., Strosberg A.D., Nahmias C. Recept. Channels 2:271-280(1994) [PubMed: 7719706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[7]	"Sequence of the AGTR2 gene in Cantonese." Zhang M., Ma H., Wang B., Zhao Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]	"Isolation of complete coding sequence for angiotensin II receptor, type 2 (AGTR2)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[10]	Rieder M.J., da Ponte S.H., Kuldanek S.A., Rajkumar N., Smith J.D., Toth E.J., Nickerson D.A. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[13]	Katsuya T., Dzau V.J. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-22. Tissue: Blood.
[14]	Warnecke C.H., Holzmeister J., Regitz-Zagrosek V., Fleck E. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-16. Tissue: Uterus.
[15]	"Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP." Nouet S., Amzallag N., Li J.-M., Louis S., Seitz I., Cui T.-X., Alleaume A.-M., Di Benedetto M., Boden C., Masson M., Strosberg A.D., Horiuchi M., Couraud P.-O., Nahmias C. J. Biol. Chem. 279:28989-28997(2004) [PubMed: 15123706] [Abstract] Cited for: INTERACTION WITH MTUS1, FUNCTION.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBLGenBankDDBJ	U20860 Genomic DNA. Translation: AAA85851.1. L34579 Genomic DNA. Translation: AAA98990.1. U10273 Genomic DNA. Translation: AAA61794.1. U15592 Genomic DNA. Translation: AAA50762.1. U16957 mRNA. Translation: AAA67753.1. U27478 Genomic DNA. Translation: AAA84900.1. AY536522 Genomic DNA. Translation: AAS45437.1. AY322542 Genomic DNA. Translation: AAP84355.1. AY324607 Genomic DNA. Translation: AAP72969.1. CR541969 mRNA. Translation: CAG46767.1. AL732602 Genomic DNA. Translation: CAI40984.1. BC095504 mRNA. Translation: AAH95504.1. X87723 mRNA. Translation: CAA61022.1.
PIR	JC2543.
RefSeq	NP_000677.2.
UniGene	Hs.405348
3D structure databases
HSSP	HSSP built from PDB template 1DDD based on UniProtKB P34996.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50052.
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSG00000180772. Homo sapiens. [Contig view]
GeneID	186.
KEGG	hsa:186.
Organism-specific databases
HGNC	HGNC:338. AGTR2.
MIM	300034. gene+phenotype.
PharmGKB	PA44.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P50052.
HOVERGEN	P50052.
Gene expression databases
ArrayExpress	P50052.
CleanEx	HS_AGTR2.
GermOnline	ENSG00000180772. Homo sapiens.
Family and domain databases
InterPro	IPR000147. ATII_AT2_rcpt. IPR000248. ATII_rcpt. IPR001186. BK_rcpt_B1. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF268. ATII_AT2_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00241. ANGIOTENSINR. PR00636. ANGIOTENSN2R. PR00993. BRADYKINNB1R. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [