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P52108

- RSTA_ECOLI

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Protein
Transcriptional regulatory protein RstA
Gene
rstA, urpT, b1608, JW1600

Gene:

rstA, urpT, b1608, JW1600
Organism
Escherichia coli (strain K12)
Status
Reviewed - - Experimental evidence at protein leveli

UniProt

P52108 - RSTA_ECOLI

Protein:

Transcriptional regulatory protein RstA
Protein Existence: Experimental evidence at protein level

Functioni

Member of the two-component regulatory system RstB/RstA.

GO - Molecular functioni

  1. DNA bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:RSTA-MONOMER.
ECOL316407:JW1600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein RstA
Gene namesi
Name:rstA
Synonyms:urpT
Ordered Locus Names:b1608, JW1600
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13190. rstA.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasmInferred from electronic annotationi Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Chaini1 – 239239Transcriptional regulatory protein RstA
PRO_0000081223

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Modified residuei5214-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated by RstB.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP52108.

Expressioni

Inductioni

Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system.1 Publication

Gene expression databases

GenevestigatoriP52108.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
kdpEP218662EBI-558990,EBI-6403634

Protein-protein interaction databases

DIPiDIP-10807N.
IntActiP52108. 12 interactions.
MINTiMINT-1274913.
STRINGi511145.b1608.

Structurei

3D structure databases

ProteinModelPortaliP52108.
SMRiP52108. Positions 4-235.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Domaini3 – 116114Response regulatory

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
KOiK07661.
OMAiLTHREYE.
OrthoDBiEOG6G4VQG.
ProtClustDBiPRK10701.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52108-1 [UniParc]FASTA

« Hide

MNTIVFVEDD AEVGSLIAAY LAKHDMQVTV EPRGDQAEET ILRENPDLVL    50
LDIMLPGKDG MTICRDLRAK WSGPIVLLTS LDSDMNHILA LEMGACDYIL 100
KTTPPAVLLA RLRLHLRQNE QATLTKGLQE TSLTPYKALH FGTLTIDPIN 150
RVVTLANTEI SLSTADFELL WELATHAGQI MDRDALLKNL RGVSYDGLDR 200
SVDVAISRLR KKLLDNAAEP YRIKTVRNKG YLFAPHAWE 239
Length:239
Mass (Da):26,704
Last modified:June 26, 2007 - v2
Checksum:i409A1B3A2588A77D
GO

Sequence conflict

The sequence AAA82081.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA15346.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41101 Genomic DNA. Translation: AAA82081.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74680.2.
AP009048 Genomic DNA. Translation: BAA15346.1. Different initiation.
PIRiB64917.
RefSeqiNP_416125.2. NC_000913.3.
YP_489871.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74680; AAC74680; b1608.
BAA15346; BAA15346; BAA15346.
GeneIDi12932769.
946199.
KEGGiecj:Y75_p1584.
eco:b1608.
PATRICi32118518. VBIEscCol129921_1679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41101 Genomic DNA. Translation: AAA82081.1 . Different initiation.
U00096 Genomic DNA. Translation: AAC74680.2 .
AP009048 Genomic DNA. Translation: BAA15346.1 . Different initiation.
PIRi B64917.
RefSeqi NP_416125.2. NC_000913.3.
YP_489871.1. NC_007779.1.

3D structure databases

ProteinModelPortali P52108.
SMRi P52108. Positions 4-235.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-10807N.
IntActi P52108. 12 interactions.
MINTi MINT-1274913.
STRINGi 511145.b1608.

Proteomic databases

PaxDbi P52108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74680 ; AAC74680 ; b1608 .
BAA15346 ; BAA15346 ; BAA15346 .
GeneIDi 12932769.
946199.
KEGGi ecj:Y75_p1584.
eco:b1608.
PATRICi 32118518. VBIEscCol129921_1679.

Organism-specific databases

EchoBASEi EB2982.
EcoGenei EG13190. rstA.

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034819.
KOi K07661.
OMAi LTHREYE.
OrthoDBi EOG6G4VQG.
ProtClustDBi PRK10701.

Enzyme and pathway databases

BioCyci EcoCyc:RSTA-MONOMER.
ECOL316407:JW1600-MONOMER.

Miscellaneous databases

PROi P52108.

Gene expression databases

Genevestigatori P52108.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publicationsDownload
  1. Kuempel P.L.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map."
    Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K.
    , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.
    DNA Res. 3:363-377(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "The complete genome sequence of Escherichia coli K-12."
    Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
    Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "In vivo characterization of tus gene expression in Escherichia coli."
    Roecklein B.A., Kuempel P.L.
    Mol. Microbiol. 6:1655-1661(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: MAPPING.
  6. "Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli."
    Minagawa S., Ogasawara H., Kato A., Yamamoto K., Eguchi Y., Oshima T., Mori H., Ishihama A., Utsumi R.
    J. Bacteriol. 185:3696-3702(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: K12.
  7. "Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
    Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
    J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry nameiRSTA_ECOLI
AccessioniPrimary (citable) accession number: P52108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 26, 2007
Last modified: March 19, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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