Reviewed, UniProtKB/Swiss-Prot P52949 (HXA5_RAT)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A5
Alternative name(s):
    Hox-1.3

Gene names

Name:	Hoxa5
Synonyms:	Hox-1.3, Hoxa-5

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	233 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	‹1 – ›233	›233	Homeobox protein Hox-A5
Regions
	DNA binding	174 – 233	60	Homeobox
	Motif	155 – 160	6	Antp-type hexapeptide
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	233	1

Sequences

	Sequence		Length	Mass (Da)
	P52949-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0937608EEDAF368C	FASTA	233	25,391
	10 20 30 40 50 60 HNYGDHSSVS EQFRDSASMH SGRYGYGYNG MDLSVGRSGS GHFGSGEXXR SYXAGASAAP 70 80 90 100 110 120 AEPRYSQPAT STHSPPPDPL PCSAVAPLPG SDTHHGGKNS LGNSSGCSAN CGSTHISSRE 130 140 150 160 170 180 GVGTASAAEE DAPASSEQAG AQSEPSPAPP AQPQIYPWMR KLHISHDNIG GPEGKRARTC 190 200 210 220 230 YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK KDK

References

[1]	"Cloning and sequence analysis of homeobox transcription factor cDNAs with an inosine-containing probe." Gorski D.H., LePage D.F., Walsh K. BioTechniques 16:856-858(1994) [PubMed: 7915120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aorta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L03556 mRNA. Translation: AAA67844.1.
PIR	I65197.
UniGene	Rn.8465
3D structure databases
HSSP	HSSP built from PDB template 1SAN based on UniProtKB P02833.
SMR	P52949. Positions 175-232.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000006466. Rattus norvegicus. [Contig view]
Organism-specific databases
RGD	620609. Hoxa5.
Phylogenomic databases
HOVERGEN	P52949.
Gene expression databases
ArrayExpress	P52949.
GermOnline	ENSRNOG00000006466. Rattus norvegicus.
Family and domain databases
InterPro	IPR001827. Antennapedia. IPR001356. Homeobox. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

HXA5_RAT

Accession

Primary (citable) accession number: P52949

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 22, 2008
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)