Reviewed, UniProtKB/Swiss-Prot P53053 (COS12_YEAST)

Names and origin

Protein names

Recommended name:
    Protein COS12

Gene names

Name:	COS12
Ordered Locus Names:	YGL263W
ORF Names:	NRC380

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the DUP/COS family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 380	380	Protein COS12
Regions
	Topological domain	1 – 70	70	Cytoplasmic Potential
	Transmembrane	71 – 91	21	Potential
	Topological domain	92 – 231	140	Extracellular Potential
	Transmembrane	232 – 252	21	Potential
	Topological domain	253 – 257	5	Cytoplasmic Potential
	Transmembrane	258 – 278	21	Potential
	Topological domain	279 – 380	102	Extracellular Potential

Sequences

	Sequence		Length	Mass (Da)
	P53053-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 52F58F4E400CA596	FASTA	380	44,804
	10 20 30 40 50 60 MDGAKFENTV AFLPSEIFDC YNSTLPKNVF RSFVTWSCYE KFNSLEFRTW LLMWLPLIIA 70 80 90 100 110 120 WKIRGKRHYL VIVTALMFEV LYFLWTYSYI FRERTLGKQV SQFAKEIITN TPGIDTEDWE 130 140 150 160 170 180 RVAVNFNSYL YENKLWNTEY FFFDGSSCQE AFRKMLLEPF SLKKNDFANA KVPDGSVCYT 190 200 210 220 230 240 EKALQVYFTQ IERKWHWINS EGFLHNKTTQ SVQFSKHGYG SKLLWAFKEV TIMNSRFAFF 250 260 270 280 290 300 SIAYLNGLLT IPRLRNSLHI LYVCAVLSSM IIEYLIGIDK FRFKSMNLIH KLQFLSYITC 310 320 330 340 350 360 GHEKSDATNW SQIAKRTNTY MFEQKIWNSP ILFSDGIDCE KFFKWYFSTP VSSQASLSVG 370 380 STDFELWPYI KEAQSACNDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae." Coissac E., Maillier E., Robineau S., Netter P. Yeast 12:1555-1562(1996) [PubMed: 8972578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X94357 Genomic DNA. Translation: CAA64124.1. Z72785 Genomic DNA. Translation: CAA96983.1.
PIR	S61598.
RefSeq	NP_011251.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5034N.
Genome annotation databases
Ensembl	YGL263W. Saccharomyces cerevisiae. [Contig view]
GeneID	852628.
GenomeReviews	Gene locus YGL263W in contig Y13135_GR.
KEGG	sce:YGL263W.
NMPDR	fig|4932.3.peg.2353.
Organism-specific databases
CYGD	YGL263w.
SGD	S000003232. COS12.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P53053.
Gene expression databases
ArrayExpress	P53053.
GermOnline	YGL263W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001142. DUP. [Graphical view]
Pfam	PF00674. DUP. 2 hits. [Graphical view]
ProDom	P53053. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	P53053.
ProtoNet	Search...

Entry information

Entry name

COS12_YEAST

Accession

Primary (citable) accession number: P53053

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 22, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)