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Reviewed, UniProtKB/Swiss-Prot P53070 (MTO1_YEAST)

Last modified July 22, 2008. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Mitochondrial translation optimization protein 1
Gene names
Name: MTO1
Synonyms: IPS1
Ordered Locus Names: YGL236C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length669 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

Cofactor

FAD By similarity.

Subunit structure

Forms an heterodimer with MSS1.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the mnmG family.

Sequence caution

The sequence CAA96953.1 differs from that shown. Reason: Frameshift at position 663.

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Ontologies

Keywords

   Biological processtRNA processing
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandFAD
Flavoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processresponse to drug

Inferred from mutant phenotype. Source: SGD

tRNA modification

Inferred from mutant phenotype. Source: SGD

translation Ref.2

Inferred from mutant phenotype. Source: SGD

   Cellular componentmitochondrion Ref.2

Inferred from direct assay. Source: SGD

   Molecular functionidentical protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-11579,EBI-11579

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Transit peptide1 – 5959Mitochondrion Potential
Chain60 – 669610Mitochondrial translation optimization protein 1

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Sequences

Sequence LengthMass (Da)Tools
P53070-1 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 917F22AE324F1B87

FASTA66974,215
        10         20         30         40         50         60 
MLRVTTLASS CTSFPLQVLR RRLTISSLTS FQPTTKTQVV VIGAGHAGCE AAAASSRTGA 

        70         80         90        100        110        120 
HTTLITPSLT DIGKCSCNPS IGGVGKGILV KEIDALDGLM GKVTDLAGVQ FKMLNRSKGP 

       130        140        150        160        170        180 
AVWGPRAQID RELYKKYMQR ELSDKKAHPN LSLLQNKVAD LILYDPGCGH KVIKGVVLDD 

       190        200        210        220        230        240 
GTQVGADQVI ITTGTFLSAE IHIGDKRIAA GRIGEQPTYG ISNTLQNEVG FQLGRLKTGT 

       250        260        270        280        290        300 
PARLAKESID FSALEVQKGD ALPVPMSFLN ETVSVEPTKQ LDCFGTHTTP QMHDFLRNNL 

       310        320        330        340        350        360 
HQSIHIQDTT IKGPRYCPSI EAKILRFPDR SSHKIWLEPE GFNSDVIYPN GISNSMPEDV 

       370        380        390        400        410        420 
QLQMMRLIPG MANVEILQPA YGVEYDYVDP RQLKPSLETK LVDGLFLAGQ INGTTGYEEA 

       430        440        450        460        470        480 
AAQGIIAGIN AGLLSRQERE QLVLKRSEAY IGVLIDDLIN NGVIEPYRMF TSRSEFRISV 

       490        500        510        520        530        540 
RADNADFRLT PIGAQLGIIS PVRLSQYSRD KHLYDETIRA LQNFKLSSQK WSSLLQANIA 

       550        560        570        580        590        600 
PQAENRSAWE IFRFKDMDLH KLYECIPDLP INLLDIPMHV VTKINIQGKY EPYIVKQNQF 

       610        620        630        640        650        660 
VKAFQADENM LLPQDYDYRQ LPTLSTECKL LLNRVQPLTI GQARRIQGIT AAALFELYRV 


ARKPSQPVM

« Hide

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed: 9169869] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae."
Colby G., Wu M., Tzagoloff A.
J. Biol. Chem. 273:27945-27952(1998) [PubMed: 9774408] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MSS1.
[3]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed: 12748633] [Abstract]
Cited for: IDENTIFICATION OF FRAMESHIFT.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z72758 Genomic DNA. Translation: CAA96953.1. Frameshift.
PIRS64258.
RefSeqNP_011278.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:4488N.
IntActP53070.

Proteomic databases

PeptideAtlasP53070.

Genome annotation databases

EnsemblYGL236C. Saccharomyces cerevisiae. [Contig view]
GeneID852616.
GenomeReviewsGene locus YGL236C in contig Y13135_GR.
KEGGsce:YGL236C.
NMPDRfig|4932.3.peg.2381.

Organism-specific databases

CYGDYGL236c.
SGDS000003205. MTO1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP53070.

Gene expression databases

ArrayExpressP53070.
GermOnlineYGL236C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002218. GIDA.
IPR004416. GidA_sub.
[Graphical view]
PANTHERPTHR11806. GIDA. 1 hit.
PfamPF01134. GIDA. 1 hit.
[Graphical view]
ProDomPD003738. GIDA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00136. gidA. 1 hit.
PROSITEPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

LinkHubP53070.
ProtoNetSearch...

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Entry information

Entry nameMTO1_YEAST
AccessionPrimary (citable) accession number: P53070
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2006
Last modified: July 22, 2008
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents