Reviewed, UniProtKB/Swiss-Prot P53088 (NCS6_YEAST)

Names and origin

Protein names

Recommended name:
    Protein NCS6

Gene names

Name:	NCS6
Ordered Locus Names:	YGL211W
ORF Names:	YGL210W-A

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the UPF0021 family.
Sequence caution	The sequence AAC49498.1 differs from that shown. Reason: Frameshift at position 318. The sequence CAA96927.1 differs from that shown. Reason: Frameshift at positions 175, 247 and 304.

Ontologies

Keywords
Cellular component	Mitochondrion
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein urmylation Inferred from mutant phenotype. Source: SGD response to drug Inferred from mutant phenotype. Source: SGD tRNA wobble uridine modification Inferred from mutant phenotype. Source: SGD
Cellular component	mitochondrion Ref.5 Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ESS1	P22696	1	EBI-24137,EBI-6679

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 359	359	Protein NCS6
Experimental info
	Sequence conflict	356 – 359	4	KLSF → NSA in AAC49498. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P53088-1 [UniParc]. Last modified October 3, 2006. Version 3. Checksum: F04BB5B93F642CC6	FASTA	359	39,987
	10 20 30 40 50 60 MSFTAPSDPV NKPTKVKVSQ LCELCHSRKA LIRRPKNLSK LCKQCFCLVF ETEIHNTIVA 70 80 90 100 110 120 NNLFQRGEKV AVGASGGKDS TVLAHMLKLL NDRYDYGIEI VLLSIDEGII GYRDDSLATV 130 140 150 160 170 180 KRNQQQYGLP LEIFSFKDLY DWTMDEIVSV AGIRNSCTYC GVFRRQSLDR GAAKLGISHV 190 200 210 220 230 240 VTGHNADDMA ETVLMNILRG DVARLEKSTA IITQSSGSPI KRSKPFKYSY QKEIVLYAHY 250 260 270 280 290 300 MKLDYFSTEC TYAPEAFRGT AREYMKNLEA VRPSCIIDII QSGENLALKA KKSNAGKRVV 310 320 330 340 350 KFVDGNRCAR CGYLSSNNIC KACMLLEGLE KSRAQVAIEN DTSADGAALK LRALEKLSF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames." Kail M., Juettner E., Vaux D. Yeast 12:799-807(1996) [PubMed: 8813766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Analysis of 21.7 kb DNA sequence from the left arm of chromosome VII reveals 11 open reading frames: two correspond to new genes." Feuermann M., Simeonava L., Souciet J.-L., Potier S. Yeast 13:475-477(1997) [PubMed: 9153757] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	"Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii." Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P. Genome Biol. 4:RESEARCH45.1-RESEARCH45.13(2003) [PubMed: 12844361] [Abstract] Cited for: IDENTIFICATION OF FRAMESHIFTS.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U33754 Genomic DNA. Translation: AAC49498.1. Frameshift. Z72733 Genomic DNA. Translation: CAA96927.1. Frameshift.
PIR	S64230. S71668.
RefSeq	NP_011304.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P53088.
Proteomic databases
PeptideAtlas	P53088.
Genome annotation databases
Ensembl	YGL211W. Saccharomyces cerevisiae. [Contig view]
GeneID	852661.
GenomeReviews	Gene locus YGL211W in contig Y13135_GR.
KEGG	sce:YGL211W.
NMPDR	fig|4932.3.peg.2407.
Organism-specific databases
CYGD	YGL211w.
SGD	S000003179. NCS6.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P53088.
Gene expression databases
GermOnline	YGL211W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR012089. ATPase_YdaO. IPR011063. PP_loop. IPR014729. Rossmann-like_a/b/a_fold. IPR000541. UPF0021. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01171. ATP_bind_3. 1 hit. [Graphical view]
PIRSF	PIRSF004976. ATPase_YdaO. 1 hit.
PROSITE	PS01263. UPF0021. 1 hit. [Graphical view]
ProDom	P53088. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	P53088.
ProtoNet	Search...

Entry information

Entry name

NCS6_YEAST

Accession

Primary (citable) accession number: P53088
Secondary accession number(s): Q92322

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 3, 2006
Last modified:	July 22, 2008
This is version 55 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)