Reviewed, UniProtKB/Swiss-Prot P54265 (DMPK_MOUSE)

Names and origin

Protein names

Recommended name:
    Myotonin-protein kinase
    EC=2.7.11.1
Alternative name(s):
    Myotonic dystrophy protein kinase
      Short name=MDPK
    DM-kinase
      Short name=DMK
    DMPK
    MT-PK

Gene names

Name:	Dmpk
Synonyms:	Dm15, Mdpk

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	631 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Enzyme regulation	Activated in response to G protein second messengers. Maintained in an inactive conformation by the negative autoregulatory C-terminal coiled-coil region. Coiled-coil mediated oligomerization correlated with enhanced catalytic activity as is proteolytically cleavage near the C-terminus By similarity.
Tissue specificity	Expressed in all tissues examinated to date, with a predominance in brain, skeletal muscle, heart, and other tissues containing smooth muscle. Primarily detected in striated muscle structures of the 14.5 day embryo, including all major muscles in the skeletal structures, cardiac muscle, diaphragm, and the smooth muscle of the lung and gut. In the heart, expression is restricted to the cardiomyocytes in the ventricle and atrium.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Inferred from mutant phenotype. Source: MGI regulation of heart contraction Ref.5 Inferred from direct assay. Source: UniProtKB regulation of small GTPase mediated signal transduction Inferred from sequence or structural similarity. Source: UniProtKB regulation of sodium ion transport Inferred from mutant phenotype. Source: MGI
Molecular function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB identical protein binding Inferred from sequence or structural similarity. Source: UniProtKB protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Notes: Additional isoforms seem to exist.

Isoform 1 (identifier: P54265-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P54265-2)

The sequence of this isoform differs from the canonical sequence as follows:
     328-356: Missing.

Isoform 3 (identifier: P54265-3)

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.

Isoform 4 (identifier: P54265-4)

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.
     412-416: DNQVP → LKRPT
     417-631: Missing.

Isoform 5 (identifier: P54265-5)

The sequence of this isoform differs from the canonical sequence as follows:
     536-537: AI → DP
     538-631: Missing.

Isoform 6 (identifier: P54265-6)

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.
     536-537: AI → DP
     538-631: Missing.

Isoform 7 (identifier: P54265-7)

The sequence of this isoform differs from the canonical sequence as follows:
     536-557: AITGVPSPRATDPPSHLDGPPA → GESLTCFQPRGHWVEMGGMLGV
     558-631: Missing.

Isoform 8 (identifier: P54265-8)

The sequence of this isoform differs from the canonical sequence as follows:
     552-631: LDGPPAVAVG...WCFPGATFAP → MAPRPWLWAS...SREPPSPPEP

Isoform 9 (identifier: P54265-9)

The sequence of this isoform differs from the canonical sequence as follows:
     378-382: Missing.
     552-631: LDGPPAVAVG...WCFPGATFAP → MAPRPWLWAS...SREPPSPPEP

Isoform 10 (identifier: P54265-10)

The sequence of this isoform differs from the canonical sequence as follows:
     552-562: LDGPPAVAVGQ → ASRQILPKGTP
     563-631: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 631	631	Myotonin-protein kinase
Regions
	Domain	71 – 339	269	Protein kinase
	Domain	340 – 415	76	AGC-kinase C-terminal
	Nucleotide binding	77 – 85	9	ATP By similarity
	Coiled coil	464 – 532	69	Potential
	Compositional bias	597 – 604	8	Poly-Ala
Sites
	Active site	195	1	Proton acceptor By similarity
	Binding site	100	1	ATP By similarity
Amino acid modifications
	Modified residue	216	1	Phosphoserine; by autocatalysis By similarity
	Modified residue	228	1	Phosphoserine; by autocatalysis By similarity
	Modified residue	234	1	Phosphothreonine; by autocatalysis By similarity
Natural variations
	Alternative sequence	328 – 356	29	Missing in isoform 2.
	Alternative sequence	378 – 382	5	Missing in isoform 3, isoform 4, isoform 6 and isoform 9.
	Alternative sequence	412 – 416	5	DNQVP → LKRPT in isoform 4.
	Alternative sequence	417 – 631	215	Missing in isoform 4.
	Alternative sequence	536 – 557	22	AITGV…DGPPA → GESLTCFQPRGHWVEMGGML GV in isoform 7.
	Alternative sequence	536 – 537	2	AI → DP in isoform 5 and isoform 6.
	Alternative sequence	538 – 631	94	Missing in isoform 5 and isoform 6.
	Alternative sequence	552 – 631	80	LDGPP…ATFAP → MAPRPWLWASARWWGQAPCT AVTCCSLPGSLGLAYPRRVA CSCSPLLWLLPPHWAALGWW PIPAVSPQSGVSREPPSPPE P in isoform 8 and isoform 9.
	Alternative sequence	552 – 562	11	LDGPPAVAVGQ → ASRQILPKGTP in isoform 10.
	Alternative sequence	558 – 631	74	Missing in isoform 7.
	Alternative sequence	563 – 631	69	Missing in isoform 10.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 5EE800A37EA81DF4	FASTA	631	69,602
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP 430 440 450 460 470 480 MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE 490 500 510 520 530 540 VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV 550 560 570 580 590 600 PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL 610 620 630 AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
	Isoform 2 [UniParc]. Checksum: 8A9EBB4E930E5EB0		602	66,397
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRDFE GATDTCNFDV VEDRLTAMVS GGGETLSDMQ 370 380 390 400 410 420 EDMPLGVRLP FVGYSYCCMA FRDNQVPDPT PMELEALQLP VSDLQGLDLQ PPVSPPDQVA 430 440 450 460 470 480 EEADLVAVPA PVAEAETTVT LQQLQEALEE EVLTRQSLSR ELEAIRTANQ NFSSQLQEAE 490 500 510 520 530 540 VRNRDLEAHV RQLQERMEML QAPGAAAITG VPSPRATDPP SHLDGPPAVA VGQCPLVGPG 550 560 570 580 590 600 PMHRRHLLLP ARIPRPGLSE ARCLLLFAAA LAAAATLGCT GLVAYTGGLT PVWCFPGATF AP
	Isoform 3 [UniParc]. Checksum: 84F11B047BB340EF		626	69,244
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDVV EDRLTAMETL SDMQEDMPLG VRLPFVGYSY CCMAFRDNQV PDPTPMELEA 430 440 450 460 470 480 LQLPVSDLQG LDLQPPVSPP DQVAEEADLV AVPAPVAEAE TTVTLQQLQE ALEEEVLTRQ 490 500 510 520 530 540 SLSRELEAIR TANQNFSSQL QEAEVRNRDL EAHVRQLQER MEMLQAPGAA AITGVPSPRA 550 560 570 580 590 600 TDPPSHLDGP PAVAVGQCPL VGPGPMHRRH LLLPARIPRP GLSEARCLLL FAAALAAAAT 610 620 LGCTGLVAYT GGLTPVWCFP GATFAP
	Isoform 4 [UniParc]. Checksum: 24F3F18634D0131C		411	46,532
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 ATDTCNFDVV EDRLTAMETL SDMQEDMPLG VRLPFVGYSY CCMAFRLKRP T
	Isoform 5 [UniParc]. Checksum: 21F148D98B3657BB		537	60,161
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP 430 440 450 460 470 480 MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE 490 500 510 520 530 VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAADP
	Isoform 6 [UniParc]. Checksum: A79E9629B958241E		532	59,803
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDVV EDRLTAMETL SDMQEDMPLG VRLPFVGYSY CCMAFRDNQV PDPTPMELEA 430 440 450 460 470 480 LQLPVSDLQG LDLQPPVSPP DQVAEEADLV AVPAPVAEAE TTVTLQQLQE ALEEEVLTRQ 490 500 510 520 530 SLSRELEAIR TANQNFSSQL QEAEVRNRDL EAHVRQLQER MEMLQAPGAA DP
	Isoform 7 [UniParc]. Checksum: D0247256B70FD18C		557	62,322
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP 430 440 450 460 470 480 MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE 490 500 510 520 530 540 VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAGESLT 550 CFQPRGHWVE MGGMLGV
	Isoform 8 [UniParc]. Checksum: D1576187FFBB8824		632	70,329
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP 430 440 450 460 470 480 MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE 490 500 510 520 530 540 VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV 550 560 570 580 590 600 PSPRATDPPS HMAPRPWLWA SARWWGQAPC TAVTCCSLPG SLGLAYPRRV ACSCSPLLWL 610 620 630 LPPHWAALGW WPIPAVSPQS GVSREPPSPP EP
	Isoform 9 [UniParc]. Checksum: C5DD789C58BE9379		627	69,972
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDVV EDRLTAMETL SDMQEDMPLG VRLPFVGYSY CCMAFRDNQV PDPTPMELEA 430 440 450 460 470 480 LQLPVSDLQG LDLQPPVSPP DQVAEEADLV AVPAPVAEAE TTVTLQQLQE ALEEEVLTRQ 490 500 510 520 530 540 SLSRELEAIR TANQNFSSQL QEAEVRNRDL EAHVRQLQER MEMLQAPGAA AITGVPSPRA 550 560 570 580 590 600 TDPPSHMAPR PWLWASARWW GQAPCTAVTC CSLPGSLGLA YPRRVACSCS PLLWLLPPHW 610 620 AALGWWPIPA VSPQSGVSRE PPSPPEP
	Isoform 10 [UniParc]. Checksum: C8D00A5C40223DBD		562	62,682
	10 20 30 40 50 60 MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 310 320 330 340 350 360 LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP 430 440 450 460 470 480 MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE 490 500 510 520 530 540 VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV 550 560 PSPRATDPPS HASRQILPKG TP

References

[1]	"Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene." Mahadevan M.S., Amemiya C., Jansen G., Sabourin L., Baird S., Neville C.E., Wormskamp N., Segers B., Batzer M., Lamerdin J., de Jong P.J., Wieringa B., Korneluk R.G. Hum. Mol. Genet. 2:299-304(1993) [PubMed: 8499920] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"No imprinting involved in the expression of DM-kinase mRNAs in mouse and human tissues." Jansen G., Bartolomei M., Kalscheuer V., Merkx G., Wormskamp N., Mariman E., Smeets D., Ropers H.-H., Wieringa B. Hum. Mol. Genet. 2:1221-1227(1993) [PubMed: 8401505] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/Sv.
[3]	"Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs." Jansen G., Mahadevan M.S., Amemiya C., Wormskamp N., Segers B., Hendriks W., O'Hoy K., Baird S., Sabourin L., Lennon G., Jap P.L., Iles D., Coerwinkel M., Hofker M., Carrano A.V., de Jong P.J., Korneluk R.G., Wieringa B. Nat. Genet. 1:261-266(1992) [PubMed: 1302022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 117-631 (ISOFORMS 2; 4; 5 AND 8). Tissue: Brain.
[4]	"Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties." Groenen P.J.T.A., Wansink D.G., Coerwinkel M., van den Broek W., Jansen G., Wieringa B. Hum. Mol. Genet. 9:605-616(2000) [PubMed: 10699184] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 3; 5; 6; 8 AND 9).
[5]	"Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum." Kaliman P., Catalucci D., Lam J.T., Kondo R., Gutierrez J.C., Reddy S., Palacin M., Zorzano A., Chien K.R., Ruiz-Lozano P. J. Biol. Chem. 280:8016-8021(2005) [PubMed: 15598648] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z38015 Genomic DNA. Translation: CAA86113.1. Z21503 , Z21504, Z21505, Z21506 Genomic DNA. Translation: CAA79715.1. S60313 mRNA. Translation: AAC60667.1. S60314 mRNA. Translation: AAC60666.1. S60315 mRNA. Translation: AAC60665.1. S60316 mRNA. Translation: AAC60664.1.
PIR	I78393. I78394. I78395. I78396. S71829.
RefSeq	NP_115794.1.
UniGene	Mm.6529
3D structure databases
HSSP	HSSP built from PDB template 1GZK based on UniProtKB P31751.
SMR	P54265. Positions 463-529.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000030409. Mus musculus. [Contig view]
GeneID	13400.
KEGG	mmu:13400.
Organism-specific databases
MGI	MGI:94906. Dmpk.
Phylogenomic databases
HOGENOM	P54265.
HOVERGEN	P54265.
Gene expression databases
ArrayExpress	P54265.
CleanEx	MM_DMPK.
GermOnline	ENSMUSG00000030409. Mus musculus.
Family and domain databases
InterPro	IPR014930. DMPK_coil. IPR000961. Pkinase_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF08826. DMPK_coil. 1 hit. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name	DMPK_MOUSE
Accession	Primary (citable) accession number: