Reviewed, UniProtKB/Swiss-Prot P54609 (CD48A_ARATH)

Names and origin

Protein names

Recommended name:
    Cell division control protein 48 homolog A
      Short name=AtCDC48a

Gene names

Name:	CDC48A
Synonyms:	CDC48
Ordered Locus Names:	At3g09840
ORF Names:	F8A24.11

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	809 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) By similarity.
Subcellular location	Nucleus. Cytoplasm › cytoskeleton › phragmoplast. Note= Primarily localized to the nucleus and, during cytokinesis, to the phragmoplast, a site where membrane vesicles are targeted in the deposition of new cell wall materials.
Developmental stage	Highly expressed in the proliferating cells of the vegetative shoot, root, floral inflorescence and flowers, and in rapidly growing cells.
Sequence similarities	Belongs to the AAA ATPase family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Protein transport Transport
Cellular component	Cytoplasm Cytoskeleton Nucleus
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	identical protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-1563238,EBI-1563238

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 809	809	Cell division control protein 48 homolog A
Regions
	Nucleotide binding	248 – 255	8	ATP Potential
	Nucleotide binding	521 – 528	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P54609-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 93222D637EA193B0	FASTA	809	89,393
	10 20 30 40 50 60 MSTPAESSDS KSKKDFSTAI LERKKSPNRL VVDEAINDDN SVVSLHPATM EKLQLFRGDT 70 80 90 100 110 120 ILIKGKKRKD TVCIALADET CEEPKIRMNK VVRSNLRVRL GDVISVHQCP DVKYGKRVHI 130 140 150 160 170 180 LPVDDTVEGV TGNLFDAYLK PYFLEAYRPV RKGDLFLVRG GMRSVEFKVI ETDPAEYCVV 190 200 210 220 230 240 APDTEIFCEG EPVKREDEER LDDVGYDDVG GVRKQMAQIR ELVELPLRHP QLFKSIGVKP 250 260 270 280 290 300 PKGILLYGPP GSGKTLIARA VANETGAFFF CINGPEIMSK LAGESESNLR KAFEEAEKNA 310 320 330 340 350 360 PSIIFIDEID SIAPKREKTN GEVERRIVSQ LLTLMDGLKS RAHVIVMGAT NRPNSIDPAL 370 380 390 400 410 420 RRFGRFDREI DIGVPDEIGR LEVLRIHTKN MKLAEDVDLE RISKDTHGYV GADLAALCTE 430 440 450 460 470 480 AALQCIREKM DVIDLEDDSI DAEILNSMAV TNEHFHTALG NSNPSALRET VVEVPNVSWN 490 500 510 520 530 540 DIGGLENVKR ELQETVQYPV EHPEKFEKFG MSPSKGVLFY GPPGCGKTLL AKAIANECQA 550 560 570 580 590 600 NFISVKGPEL LTMWFGESEA NVREIFDKAR QSAPCVLFFD ELDSIATQRG GGSGGDGGGA 610 620 630 640 650 660 ADRVLNQLLT EMDGMNAKKT VFIIGATNRP DIIDSALLRP GRLDQLIYIP LPDEDSRLNI 670 680 690 700 710 720 FKAALRKSPI AKDVDIGALA KYTQGFSGAD ITEICQRACK YAIRENIEKD IEKEKRRSEN 730 740 750 760 770 780 PEAMEEDGVD EVSEIKAAHF EESMKYARRS VSDADIRKYQ AFAQTLQQSR GFGSEFRFEN 790 800 SAGSGATTGV ADPFATSAAA AGDDDDLYN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The higher plant Arabidopsis thaliana encodes a functional CDC48 homologue which is highly expressed in dividing and expanding cells." Feiler H.S., Desprez T., Santoni V., Kronenberger J., Caboche M., Traas J. EMBO J. 14:5626-5637(1995) [PubMed: 8521820] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U37587 mRNA. Translation: AAC49120.1. AC015985 Genomic DNA. Translation: AAF23260.1. AY065076 mRNA. Translation: AAL38252.1. AY094434 mRNA. Translation: AAM19807.1.
PIR	S60112.
RefSeq	NP_187595.1.
UniGene	At.71448
3D structure databases
HSSP	HSSP built from PDB template 1E32 based on UniProtKB Q01853.
SMR	P54609. Positions 22-459.
ModBase	Search...
Protein-protein interaction databases
IntAct	P54609.
Proteomic databases
ProMEX	P54609.
Genome annotation databases
GeneID	820142.
GenomeReviews	Gene locus AT3G09840 in contig BA000014_GR.
KEGG	ath:AT3G09840.
NMPDR	fig|3702.1.peg.13004.
Organism-specific databases
GeneFarm	1893. 150.
TAIR	At3g09840.
Gene expression databases
ArrayExpress	P54609.
GermOnline	AT3G09840. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase_core. IPR003959. AAA_ATPase_core. IPR003960. AAA_ATPase_CS. IPR005938. AAA_CDC48. IPR009010. Asp_de-COase-like_fold. IPR003338. ATPaseVAT_N. IPR004201. Cdc48_2. [Graphical view]
Gene3D	G3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
Pfam	PF00004. AAA. 2 hits. PF02933. CDC48_2. 1 hit. PF02359. CDC48_N. 1 hit. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
TIGRFAMs	TIGR01243. CDC48. 1 hit.
PROSITE	PS00674. AAA. 2 hits. [Graphical view]
ProDom	P54609. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CD48A_ARATH

Accession

Primary (citable) accession number: P54609

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 22, 2008
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)