Reviewed, UniProtKB/Swiss-Prot P54922 (ADPRH_HUMAN)

Names and origin

Protein names

Recommended name:
    [Protein ADP-ribosylarginine] hydrolase
      Short name(s)=ADP-ribosylarginine hydrolase
    EC=3.2.2.19
Alternative name(s):
    ADP-ribose-L-arginine cleaving enzyme

Gene names

Name:	ADPRH
Synonyms:	ARH1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the reverse reaction of mono-ADP-ribosylation.
Catalytic activity	Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-ribose + protein-L-arginine. N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-ribose + L-arginine.
Sequence similarities	Belongs to the ADP-ribosylglycohydrolase family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	protein modification process Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Molecular function	ADP-ribosylarginine hydrolase activity Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 357	357	[Protein ADP-ribosylarginine] hydrolase

Sequences

	Sequence		Length	Mass (Da)
	P54922-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4E23B12FAE84F12B	FASTA	357	39,507
	10 20 30 40 50 60 MEKYVAAMVL SAAGDALGYY NGKWEFLQDG EKIHRQLAQL GGLDALDVGR WRVSDDTVMH 70 80 90 100 110 120 LATAEALVEA GKAPKLTQLY YLLAKHYQDC MEDMDGRAPG GASVHNAMQL KPGKPNGWRI 130 140 150 160 170 180 PFNSHEGGCG AAMRAMCIGL RFPHHSQLDT LIQVSIESGR MTHHHPTGYL GALASALFTA 190 200 210 220 230 240 YAVNSRPPLQ WGKGLMELLP EAKKYIVQSG YFVEENLQHW SYFQTKWENY LKLRGILDGE 250 260 270 280 290 300 SAPTFPESFG VKERDQFYTS LSYSGWGGSS GHDAPMIAYD AVLAAGDSWK ELAHRAFFHG 310 320 330 340 350 GDSDSTAAIA GCWWGVMYGF KGVSPSNYEK LEYRNRLEET ARALYSLGSK EDTVISL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase." Takada T., Iida K., Moss J. J. Biol. Chem. 268:17837-17843(1993) [PubMed: 8349667] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L13291 mRNA. Translation: AAA35555.1. BC063883 mRNA. Translation: AAH63883.1. BC074769 mRNA. Translation: AAH74769.1.
PIR	B47411.
RefSeq	NP_001116.1.
UniGene	Hs.99884
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	P54922.
2-D gel databases
OGP	P54922.
Genome annotation databases
Ensembl	ENSG00000144843. Homo sapiens. [Contig view]
GeneID	141.
KEGG	hsa:141.
Organism-specific databases
H-InvDB	HIX0030805.
HGNC	HGNC:269. ADPRH.
HPA	CAB001701.
MIM	603081. gene.
PharmGKB	PA24590.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	P54922.
HOVERGEN	P54922.
Gene expression databases
ArrayExpress	P54922.
CleanEx	HS_ADPRH.
GermOnline	ENSG00000144843. Homo sapiens.
Family and domain databases
InterPro	IPR012108. ADP-ribosylarg_hydro. IPR005502. Ribosyl_crysJ1. [Graphical view]
PANTHER	PTHR22957:SF7. ADP-ribosylarg_hydro. 1 hit.
Pfam	PF03747. ADP_ribosyl_GH. 1 hit. [Graphical view]
PIRSF	PIRSF016939. ADP_ribslarg_hdr. 1 hit.
ProDom	P54922. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	P54922.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ADPRH_HUMAN

Accession

Primary (citable) accession number: P54922

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 22, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)