Reviewed, UniProtKB/Swiss-Prot P55944 (MT3_PIG)

Names and origin

Protein names

Recommended name:
    Metallothionein-3
      Short name=MT-3
Alternative name(s):
    Metallothionein-III
      Short name=MT-III
    Growth inhibitory factor
      Short name=GIF

Gene names

Name:

MT3

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro By similarity.
Tissue specificity	Brain.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from sequence or structural similarity. Source: UniProtKB response to hypoxia Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 68	68	Metallothionein-3
Regions
	Region	1 – 30	30	Beta
	Region	31 – 68	38	Alpha
Sites
	Metal binding	6	1	Cluster B By similarity
	Metal binding	8	1	Cluster B By similarity
	Metal binding	14	1	Cluster B By similarity
	Metal binding	16	1	Cluster B By similarity
	Metal binding	20	1	Cluster B By similarity
	Metal binding	22	1	Cluster B By similarity
	Metal binding	25	1	Cluster B By similarity
	Metal binding	27	1	Cluster B By similarity
	Metal binding	30	1	Cluster B By similarity
	Metal binding	34	1	Cluster A By similarity
	Metal binding	35	1	Cluster A By similarity
	Metal binding	37	1	Cluster A By similarity
	Metal binding	38	1	Cluster A By similarity
	Metal binding	42	1	Cluster A By similarity
	Metal binding	45	1	Cluster A By similarity
	Metal binding	49	1	Cluster A By similarity
	Metal binding	51	1	Cluster A By similarity
	Metal binding	64	1	Cluster A By similarity
	Metal binding	66	1	Cluster A By similarity
	Metal binding	67	1	Cluster A By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55944-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: ED801B8331E53300	FASTA	68	6,927
	10 20 30 40 50 60 MDPETCPCPT GGSCTCAGSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV CKGGEGAEAE EEKCSCCQ

References

[1]	"Identification and characterization of metallothionein III (growth inhibitory factor) from porcine brain." Chen C.-F., Wang S.-H., Lin L.-Y. Comp. Biochem. Physiol. 115B:27-32(1996) [PubMed: 8896330] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Cloning of porcine neuron growth inhibitory factor (metallothionein III) cDNA and expression of the gene in Saccharomyces cerevisiae." Wang S.-H., Chang C.-Y., Chen C.-F., Tam M.F., Shih Y.H., Lin L.-Y. Gene 203:189-197(1997) [PubMed: 9426250] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U95969 mRNA. Translation: AAC39165.1.
PIR	JC6521.
RefSeq	NP_999221.1.
UniGene	Ssc.15694
3D structure databases
HSSP	HSSP built from PDB template 1JI9 based on UniProtKB P28184.
ModBase	Search...
Genome annotation databases
GeneID	397123.
KEGG	ssc:397123.
Phylogenomic databases
HOVERGEN	P55944.
Family and domain databases
InterPro	IPR015874. 4-disulphide_core. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00003. 4DISULPHCORE. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P55944. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MT3_PIG

Accession

Primary (citable) accession number: P55944

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	July 22, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)