Reviewed, UniProtKB/Swiss-Prot P56089 (GLYA_HELPY)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase
      Short name(s)=Serine methylase, SHMT
    EC=2.1.2.1

Gene names

Name:	glyA
Ordered Locus Names:	HP_0183

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine.
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate pathway.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon compound metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 416	416	Serine hydroxymethyltransferase
Sites
	Binding site	226	1	Pyridoxal phosphate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56089-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 42BB0CD4433CD708	FASTA	416	45,710
	10 20 30 40 50 60 MAYFLEQTDS EIFELIFEEY KRQNEHLEMI ASENYTFASV MEAMGSVLTN KYAEGYPNKR 70 80 90 100 110 120 YYGGCEVVDK IESLAIERAK KLFNCQFANV QAHSGSQANN AVYHALLKPY DKILGMDLSC 130 140 150 160 170 180 GGHLTHGAKV SLTGKHYQSF SYGVNLDGYI DYEEALKIAQ SVKPEIIVCG FSAYPREIDF 190 200 210 220 230 240 KKFREIADEV GALLLGDIAH VAGLVVTGEH AHPFPHCHVV SSTTHKTLRG PRGGIILTND 250 260 270 280 290 300 EEIAAKIDKA IFPGTQGGPL MHVIAAKAVG FKENLKPEFK AYAQLVKSNM QVLAKALKEK 310 320 330 340 350 360 NHKLVSGGTS NHLLLMDFLD KPYSGKDADI ALGNAGITVN KNTIPGETRS PFVTSGIRIG 370 380 390 400 410 SAALSARGMG AKEFEIIGNK ISDILNDINN VSLQLHVKEE LKAMVNQFPV YHQPIF

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07252.1.
PIR	G64542.
RefSeq	NP_206982.1.
3D structure databases
HSSP	HSSP built from PDB template 1DFO based on UniProtKB P00477.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3405N.
Genome annotation databases
GeneID	899151.
GenomeReviews	Gene locus HP_0183 in contig AE000511_GR.
KEGG	hpy:HP0183.
NMPDR	fig|85962.1.peg.180.
TIGR	HP_0183.
Phylogenomic databases
HOGENOM	P56089.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR001085. Gly_HO-MeTrfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProDom	P56089. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

GLYA_HELPY

Accession

Primary (citable) accession number: P56089

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	July 22, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)