Reviewed, UniProtKB/Swiss-Prot P56109 (ALF_HELPY)

Names and origin

Protein names

Recommended name:
    Fructose-bisphosphate aldolase
    EC=4.1.2.13

Gene names

Name:	fba
Ordered Locus Names:	HP_0176

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Cofactor	Zinc By similarity.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class II fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 307	307	Fructose-bisphosphate aldolase
Sites
	Metal binding	80	1	Zinc By similarity
	Metal binding	83	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56109-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: ADC5696C67C69A45	FASTA	307	33,773
	10 20 30 40 50 60 MLVKGNEILL KAHKEGYGVG AFNFVNFEML NAIFEAGNEE NSPLFIQTSE GAIKYMGIDM 70 80 90 100 110 120 AVGMVKTMCE RYPHIPVALH LDHGTTFESC EKAVKAGFTS VMIDASHHAF EENLELTSKV 130 140 150 160 170 180 VKMAHNAGVS VEAELGRLMG IEDNISVDEK DAVLVNPKEA EQFVKESQVD YLAPAIGTSH 190 200 210 220 230 240 GAFKFKGEPK LDFERLQEVK RLTNIPLVLH GASAIPDNVR KSYLDAGGDL KGSKGVPFEF 250 260 270 280 290 300 LQESVKGGIN KVNTDTDLRI AFIAEVRKVA NEDKSQFDLR KFFSPAQLAL KNVVKERMKL LGSANKI

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07246.1.
PIR	H64541.
RefSeq	NP_206975.1.
3D structure databases
HSSP	HSSP built from PDB template 1GVF based on UniProtKB P42908.
ModBase	Search...
Genome annotation databases
GeneID	900140.
GenomeReviews	Gene locus HP_0176 in contig AE000511_GR.
KEGG	hpy:HP0176.
NMPDR	fig|85962.1.peg.173.
TIGR	HP_0176.
Phylogenomic databases
HOGENOM	P56109.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR011289. Fruc_bis_ald_. IPR000771. K_bP_aldolase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01116. F_bP_aldolase. 1 hit. [Graphical view]
PIRSF	PIRSF001359. F_bP_aldolase_II. 1 hit.
ProDom	PD002376. K_bP_aldolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00167. cbbA. 1 hit. TIGR01859. fruc_bis_ald_. 1 hit.
PROSITE	PS00602. ALDOLASE_CLASS_II_1. 1 hit. PS00806. ALDOLASE_CLASS_II_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ALF_HELPY

Accession

Primary (citable) accession number: P56109

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	July 22, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)